Search Results - "McKnight, A"

Young novice drivers: careless or clueless? by McKnight, A.James, McKnight, A.Scott

“…The per-mile accident rate of 16-year-old novices is approximately 10 times that of adults, a difference that has been attributed to the immaturity of youth…”
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High frequency of mosaic pathogenic variants in genes causing epilepsy-related neurodevelopmental disorders by Stosser, Mary Beth, Lindy, Amanda S, Butler, Elizabeth, Retterer, Kyle, Piccirillo-Stosser, Caitlin M, Richard, Gabriele, McKnight, Dianalee A

“…Purpose Mosaicism probably represents an underreported cause of genetic disorders due to detection challenges during routine molecular diagnostics. The purpose…”
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Genomic approaches in the search for molecular biomarkers in chronic kidney disease by Cañadas-Garre, M, Anderson, K, McGoldrick, J, Maxwell, A P, McKnight, A J

“…Chronic kidney disease (CKD) is recognised as a global public health problem, more prevalent in older persons and associated with multiple co-morbidities…”
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N-Glycan Profile and Kidney Disease in Type 1 Diabetes by Bermingham, Mairead L, Colombo, Marco, McGurnaghan, Stuart J, Blackbourn, Luke A K, Vučković, Frano, Pučić Baković, Maja, Trbojević-Akmačić, Irena, Lauc, Gordan, Agakov, Felix, Agakova, Anna S, Hayward, Caroline, Klarić, Lucija, Palmer, Colin N A, Petrie, John R, Chalmers, John, Collier, Andrew, Green, Fiona, Lindsay, Robert S, Macrury, Sandra, McKnight, John A, Patrick, Alan W, Thekkepat, Sandeep, Gornik, Olga, McKeigue, Paul M, Colhoun, Helen M

“…Poorer glycemic control in type 1 diabetes may alter N-glycosylation patterns on circulating glycoproteins, and these alterations may be linked with diabetic…”
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Growth differentiation factor 15 (GDF15) and semaglutide inhibit food intake and body weight through largely distinct, additive mechanisms by Ghidewon, M., Wald, H.S., McKnight, A. D., De Jonghe, B. C., Breen, D. M., Alhadeff, A. L., Borner, T., Grill, H. J.

“…Aims To evaluate whether the potent hypophagic and weight‐suppressive effects of growth differentiation factor‐15 (GDF15) and semaglutide combined would be a…”
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Epigenetics: intrauterine growth retardation (IUGR) modifies the histone code along the rat hepatic IGF-1 gene by Fu, Qi, Yu, Xing, Callaway, Christopher W, Lane, Robert H, McKnight, Robert A

“…Intrauterine growth restriction (IUGR) decreases serum insulin growth factor-1 (IGF-1) levels. IGF-1 is an epigenetically regulated gene that has two…”
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Supported Telemonitoring and Glycemic Control in People with Type 2 Diabetes: The Telescot Diabetes Pragmatic Multicenter Randomized Controlled Trial by Wild, Sarah H, Hanley, Janet, Lewis, Stephanie C, McKnight, John A, McCloughan, Lucy B, Padfield, Paul L, Parker, Richard A, Paterson, Mary, Pinnock, Hilary, Sheikh, Aziz, McKinstry, Brian

“…Self-monitoring of blood glucose among people with type 2 diabetes not treated with insulin does not appear to be effective in improving glycemic control. We…”
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Distinct methylation patterns in genes that affect mitochondrial function are associated with kidney disease in blood-derived DNA from individuals with Type 1 diabetes by Swan, E. J., Maxwell, A. P., McKnight, A. J.

“…Aims Epigenetic modifications, such as DNA methylation, can influence the risk of developing kidney disease. We studied methylation profiles in genes related…”
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Genetic and epigenetic factors influencing chronic kidney disease by Smyth, L J, Duffy, S, Maxwell, A P, McKnight, A J

“…Chronic kidney disease (CKD) has become a serious public health problem because of its associated morbidity, premature mortality, and attendant healthcare…”
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Commonalities in social and non-social cognitive impairments in adults with autism spectrum disorder and schizophrenia by Eack, Shaun M, Bahorik, Amber L, McKnight, Summer A.F, Hogarty, Susan S, Greenwald, Deborah P, Newhill, Christina E, Phillips, Mary L, Keshavan, Matcheri S, Minshew, Nancy J

“…Abstract Autism spectrum disorder (ASD) and schizophrenia are both conditions that are characterized by impairments in social and non-social cognition, yet…”
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Field and Laboratory Alcohol Detection With 2 Types of Transdermal Devices by Marques, Paul R., McKnight, A. Scott

“…Background:  Two types of transdermal electrochemical sensors that detect alcohol at the skin surface were evaluated. One, the AMS SCRAM™ device, is locked…”
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HIV risk and prevention among clients of a delivery-based harm reduction service during an HIV outbreak among people who use drugs in northern rural Minnesota, USA by Palayew, Adam, Knudtson, Kelly, Purchase, Sue, Clark, Shayna, Possehl, Lucia, Healy, Elise, Deutsch, Sarah, McKnight, Courtney A, Des Jarlais, Don, Glick, Sara N

“…Since 2019, multiple HIV outbreaks occurred among people who inject drugs (PWID) in Minnesota. Syringe service programs (SSPs) are evidence-based programs that…”
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Proteomic and metabolomic approaches in the search for biomarkers in chronic kidney disease by Cañadas-Garre, M., Anderson, K., McGoldrick, J., Maxwell, A.P., McKnight, A.J.

“…Chronic kidney disease (CKD) is an aging-related disorder that represents a major global public health burden. Current biochemical biomarkers, such as serum…”
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Magnetic resonance imaging of equine stifles: Technique and observations in 76 clinical cases by Waselau, M., McKnight, A., Kasparek, A.

“…Summary Magnetic resonance imaging (MRI) of equine stifle disorders is challenging. We describe a routine technique for low‐field stifle MRI under general…”
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Evaluation of a responsible beverage service and enforcement program: Effects on bar patron intoxication and potential impaired driving by young adults by Fell, James C., Fisher, Deborah A., Yao, Jie, McKnight, A. Scott

“…Objective: Studies of alcohol-related harm (violence, injury, illness) suggest that the most significant risk factors are the amount of alcohol consumed and…”
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Diabetic retinopathy at diagnosis of type 2 diabetes in Scotland by Looker, H. C., Nyangoma, S. O., Cromie, D., Olson, J. A., Leese, G. P., Black, M., Doig, J., Lee, N., Lindsay, R. S., McKnight, J. A., Morris, A. D., Philip, S., Sattar, N., Wild, S. H., Colhoun, H. M.

“…Aims/hypothesis The aim of this study was to examine the prevalence of and risk factors for diabetic retinopathy in people with newly diagnosed type 2 diabetes…”
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Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study by Smyth, L J, Kilner, J, Nair, V, Liu, H, Brennan, E, Kerr, K, Sandholm, N, Cole, J, Dahlström, E, Syreeni, A, Salem, R M, Nelson, R G, Looker, H C, Wooster, C, Anderson, K, McKay, G J, Kee, F, Young, I, Andrews, D, Forsblom, C, Hirschhorn, J N, Godson, C, Groop, P H, Maxwell, A P, Susztak, K, Kretzler, M, Florez, J C, McKnight, A J

“…A subset of individuals with type 1 diabetes mellitus (T1DM) are predisposed to developing diabetic kidney disease (DKD), the most common cause globally of…”
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Persistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes by McKeigue, Paul M, Spiliopoulou, Athina, McGurnaghan, Stuart, Colombo, Marco, Blackbourn, Luke, McDonald, Timothy J, Onengut-Gomuscu, Suna, Rich, Stephen S, A Palmer, Colin N, McKnight, John A, J Strachan, Mark W, Patrick, Alan W, Chalmers, John, Lindsay, Robert S, Petrie, John R, Thekkepat, Sandeep, Collier, Andrew, MacRury, Sandra, Colhoun, Helen M

“…The objective of this cross-sectional study was to explore the relationship of detectable C-peptide secretion in type 1 diabetes to clinical features and to…”
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Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth by Tosh, Darran N, Fu, Qi, Callaway, Christopher W, McKnight, Robert A, McMillen, Isabella C, Ross, Michael G, Lane, Robert H, Desai, Mina

“…Maternal food restriction (FR) during pregnancy results in intrauterine growth-restricted (IUGR) offspring that show rapid catch-up growth and develop…”
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Comparison of methylation patterns generated from genomic and cell-line derived DNA using the Illumina Infinium MethylationEPIC BeadChip array by Smyth, L J, Kilner, J, Maxwell, A P, McKnight, A J

“…Genomic DNA (gDNA) is the optimal source of DNA for methylation analysis. This study compared methylation patterns in gDNA derived from blood with cell-line…”
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