Search Results - "McKinnon, LR"

P16-27.Optimization of the expansion of antigen-specific CD8+ T-cells for use in a viral suppression assay by Herman, MM, McKinnon, LR, Meyers, AF, Koesters, SA, Kimani, J, Plummer, FA, Ball, TB

“…Many studies have correlated HIV-specific T-cell responses with slower HIV disease progression; however, a causal relationship has not been clearly defined…”
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P16-15. Epitope mapping of HIV-specific CD8+ T-cells responses by polyfunctional and proliferation responses reveal distinct specificity defined by function by Richmond, ME, McKinnon, LR, Kiazyk, S Koesters, Wachihi, C, Kimani, M, Kimani, J, Plummer, FA, Ball, TB

“…Meeting abstracts - A single PDF containing all abstracts in this Supplement is available at…”
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Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women by Klatt, Nichole R., Cheu, Ryan, Birse, Kenzie, Zevin, Alexander S., Perner, Michelle, Noël-Romas, Laura, Grobler, Anneke, Westmacott, Garrett, Xie, Irene Y., Butler, Jennifer, Mansoor, Leila, McKinnon, Lyle R., Passmore, Jo-Ann S., Karim, Quarraisha Abdool, Karim, Salim S. Abdool, Burgener, Adam D.

“…Antiretroviral-based strategies for HIV prevention have shown inconsistent results in women. We investigated whether vaginal microbiota modulated tenofovir gel…”
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The Evolving Facets of Bacterial Vaginosis: Implications for HIV Transmission by McKinnon, Lyle R, Achilles, Sharon L, Bradshaw, Catriona S, Burgener, Adam, Crucitti, Tania, Fredricks, David N, Jaspan, Heather B, Kaul, Rupert, Kaushic, Charu, Klatt, Nichole, Kwon, Douglas S, Marrazzo, Jeanne M, Masson, Lindi, McClelland, R Scott, Ravel, Jacques, van de Wijgert, Janneke H H M, Vodstrcil, Lenka A, Tachedjian, Gilda

“…Bacterial vaginosis (BV) is a common yet poorly understood vaginal condition that has become a major focus of HIV transmission and immunology research. Varied…”
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Non-Lactobacillus-Dominant and Polymicrobial Vaginal Microbiomes Are More Common in Younger South African Women and Predictive of Increased Risk of Human Immunodeficiency Virus Acquisition by Wang, Yiran, Noël-Romas, Laura, Perner, Michelle, Knodel, Samantha, Molatlhegi, Refilwe, Hoger, Sarah, Birse, Kenzie, Zuend, Christina Farr, McKinnon, Lyle R, Burgener, Adam D

“…Abstract Background Adolescent girls and young women aged 15‒24 years in sub-Saharan Africa are at disproportionate risk of human immunodeficiency virus (HIV)…”
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Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells by Arnold, Kelly B, Burgener, Adam, Birse, Kenzie, Romas, Laura, Dunphy, Laura J, Shahabi, Kamnoosh, Abou, Max, Westmacott, Garrett R, McCorrister, Stuart, Kwatampora, Jessie, Nyanga, Billy, Kimani, Joshua, Masson, Lindi, Liebenberg, Lenine J, Abdool Karim, Salim S, Passmore, Jo-Ann S, Lauffenburger, Douglas A, Kaul, Rupert, McKinnon, Lyle R

“…Elevated inflammatory cytokines (EMCs) at mucosal surfaces have been associated with HIV susceptibility, but the underlying mechanisms remain unclear. We…”
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Microbiome Composition and Function Drives Wound-Healing Impairment in the Female Genital Tract by Zevin, Alexander S, Xie, Irene Y, Birse, Kenzie, Arnold, Kelly, Romas, Laura, Westmacott, Garrett, Novak, Richard M, McCorrister, Stuart, McKinnon, Lyle R, Cohen, Craig R, Mackelprang, Romel, Lingappa, Jairam, Lauffenburger, Doug A, Klatt, Nichole R, Burgener, Adam D

“…The mechanism(s) by which bacterial communities impact susceptibility to infectious diseases, such as HIV, and maintain female genital tract (FGT) health are…”
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Vaginal microbiome-hormonal contraceptive interactions associate with the mucosal proteome and HIV acquisition by Noël-Romas, Laura, Perner, Michelle, Molatlhegi, Refilwe, Farr Zuend, Christina, Mabhula, Amanda, Hoger, Sarah, Lamont, Alana, Birse, Kenzie, Berard, Alicia, McCorrister, Stuart, Westmacott, Garett, Leslie, Al, Poliquin, Vanessa, Heffron, Renee, McKinnon, Lyle R, Burgener, Adam D

“…Alterations to the mucosal environment of the female genital tract, such as genital inflammation, have been associated with increased HIV acquisition in women…”
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An updated review on the effects of depot medroxyprogesterone acetate on the mucosal biology of the female genital tract by Ayele, Hossaena, Perner, Michelle, McKinnon, Lyle R., Birse, Kenzie, Farr Zuend, Christina, Burgener, Adam

“…Background Access to safe, effective, and affordable contraception is important for women’s health and essential to mitigate maternal and fetal mortality…”
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Nonoptimal bacteria species induce neutrophil-driven inflammation and barrier disruption in the female genital tract by Costa-Fujishima, Marina, Yazdanpanah, Atta, Horne, Samantha, Lamont, Alana, Lopez, Paul, Farr Zuend, Christina, Birse, Kenzie, Taverner, Morgan, Greenslade, Riley, Abou, Max, Noel-Romas, Laura, Abrenica, Bernard, Ajibola, Oluwaseun, Ikeogu, Nnamdi, Su, Ruey-Chyi, McKinnon, Lyle R., Pymar, Helen, Poliquin, Vanessa, Berard, Alicia R., Burgener, Adam D., Murooka, Thomas T.

“…Neutrophil recruitment and activation within the female genital tract are often associated with tissue inflammation, loss of vaginal epithelial barrier…”
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Simian Immunodeficiency Virus Susceptibility, Immunology, and Microbiome in the Female Genital Tract of Adolescent Versus Adult Pigtail Macaques by Berard, Alicia R, Miller, Charlene, Araínga, Mariluz, Broedlow, Courtney Ann, Noël-Romas, Laura, Schifanella, Luca, Hensley-McBain, Tiffany, Roederer, Alex, Driscoll, Connor B, Coronado, Ernesto, Manuzak, Jennifer, McKinnon, Lyle R, Villinger, Francois, Hope, Thomas J, Burgener, Adam D, Klatt, Nichole R

“…In Sub-Saharan Africa, young women 15-24 years of age account for nearly 30% of all new HIV infections, however, biological and epidemiological factors…”
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Plasma concentration of injectable contraceptive correlates with reduced cervicovaginal growth factor expression in South African women by Molatlhegi, Refilwe P., Liebenberg, Lenine J., Leslie, Alasdair, Noel-Romas, Laura, Mabhula, Amanda, Mchunu, Nobuhle, Perner, Michelle, Birse, Kenzie, Ngcapu, Sinaye, Adamson, John H., Govender, Katya, Garrett, Nigel J., Samsunder, Natasha, Burgener, Adam D., Abdool Karim, Salim S., Abdool Karim, Quarraisha, Passmore, Jo-Ann S., McKinnon, Lyle R.

“…Long-acting injectable contraceptives have been associated with mucosal immune changes and increased HIV acquisition, but studies have often been hampered by…”
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Cross-Clade CD8+ T-Cell Responses With a Preference for the Predominant Circulating Clade by McKinnon, Lyle R, Ball, T Blake, Kimani, Joshua, Wachihi, Charles, Matu, Lucy, Luo, Ma, Embree, Joanne, Fowke, Keith R, Plummer, Francis A

“…Human immunodeficiency virus (HIV) genetic diversity is a major impediment to the design of a successful vaccine. Even if an HIV vaccine is proven effective,…”
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