Search Results - "McKinnon, Karen P"

A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1-insensitive models of triple-negative breast cancer by Cheng, Ning, Watkins-Schulz, Rebekah, Junkins, Robert D, David, Clément N, Johnson, Brandon M, Montgomery, Stephanie A, Peine, Kevin J, Darr, David B, Yuan, Hong, McKinnon, Karen P, Liu, Qi, Miao, Lei, Huang, Leaf, Bachelder, Eric M, Ainslie, Kristy M, Ting, Jenny P-Y

“…Triple-negative breast cancer (TNBC) has few therapeutic options, and alternative approaches are urgently needed. Stimulator of IFN genes (STING) is becoming…”
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Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease by Bruce, Danny W, Stefanski, Heather E, Vincent, Benjamin G, Dant, Trisha A, Reisdorf, Shannon, Bommiasamy, Hemamalini, Serody, David A, Wilson, Justin E, McKinnon, Karen P, Shlomchik, Warren D, Armistead, Paul M, Ting, Jenny P Y, Woosley, John T, Blazar, Bruce R, Zaiss, Dietmar M W, McKenzie, Andrew N J, Coghill, James M, Serody, Jonathan S

“…Acute graft-versus-host disease (aGVHD) is the most common complication for patients undergoing allogeneic stem cell transplantation. Despite extremely…”
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Immune features are associated with response to neoadjuvant chemo-immunotherapy for muscle-invasive bladder cancer by Beckabir, Wolfgang, Zhou, Mi, Lee, Jin Seok, Vensko, Steven P., Woodcock, Mark G., Wang, Hsing-Hui, Wobker, Sara E., Atassi, Gatphan, Wilkinson, Alec D., Fowler, Kenneth, Flick, Leah M., Damrauer, Jeffrey S., Harrison, Michael R., McKinnon, Karen P., Rose, Tracy L., Milowsky, Matthew I., Serody, Jonathan S., Kim, William Y., Vincent, Benjamin G.

“…Neoadjuvant cisplatin-based chemotherapy is standard of care for muscle-invasive bladder cancer (MIBC). Immune checkpoint inhibition (ICI) alone, and ICI in…”
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CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease by Coghill, James M., Fowler, Kenneth A., West, Michelle L., Fulton, LeShara M., van Deventer, Hendrik, McKinnon, Karen P., Vincent, Benjamin G., Lin, Kaifeng, Panoskaltsis-Mortari, Angela, Cook, Donald N., Blazar, Bruce R., Serody, Jonathan S.

“…The infusion of donor regulatory T cells (Tregs) has been used to prevent acute graft-versus-host disease (GVHD) in mice and has shown promise in phase 1…”
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Neisseria gonorrhoeae suppresses dendritic cell-induced, antigen-dependent CD4 T cell proliferation by Zhu, Weiyan, Ventevogel, Melissa S, Knilans, Kayla J, Anderson, James E, Oldach, Laurel M, McKinnon, Karen P, Hobbs, Marcia M, Sempowski, Gregory D, Duncan, Joseph A

“…Neisseria gonorrhoeae is the second most common sexually transmitted bacterial pathogen worldwide. Diseases associated with N. gonorrhoeae cause localized…”
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SecA2 Secretion Factor of Mycobacterium tuberculosis Promotes Growth in Macrophages and Inhibits the Host Immune Response by Kurtz, Sherry, McKinnon, Karen P, Runge, Marschall S, Ting, Jenny P.-Y, Braunstein, Miriam

“…The SecA protein is present in all bacteria, and it is a central component of the general Sec-dependent protein export pathway. An unusual property of…”
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Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model by Callaway, Justin B, Smith, Scott A, Widman, Douglas G, McKinnon, Karen P, Scholle, Frank, Sempowski, Gregory D, Dittmer, Dirk P, Crowe, Jr, James E, de Silva, Aravinda M, Ting, Jenny P-Y

“…Dengue virus is a major global health threat and can lead to life-threatening hemorrhagic complications due to immune activation and cytokine production…”
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Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy by Min, Yuanzeng, Roche, Kyle C., Tian, Shaomin, Eblan, Michael J., McKinnon, Karen P., Caster, Joseph M., Chai, Shengjie, Herring, Laura E., Zhang, Longzhen, Zhang, Tian, DeSimone, Joseph M., Tepper, Joel E., Vincent, Benjamin G., Serody, Jonathan S., Wang, Andrew Z.

“…Nanoparticles can be utilized to capture tumour antigens and improve their presentation, which in turn improves the efficacy of cancer immunotherapy…”
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Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model by Robbins, Gregory R., BS, PhD, Roberts, Reid A., BS, PhD, Guo, Haitao, BS, PhD, Reuter, Kevin, BS, Shen, Tammy, BS, PhD, Sempowski, Gregory D., BS, PhD, McKinnon, Karen P., BS, PhD, Su, Lishan, BS, PhD, DeSimone, Joseph M., BS, PhD, Ting, Jenny P.-Y., BS, PhD

“…Abstract Ideal nanoparticle (NP)-based drug and vaccine delivery vectors should be free of inherent cytotoxic or immunostimulatory properties. Therefore,…”
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Treg depletion potentiates checkpoint inhibition in claudin-low breast cancer by Taylor, Nicholas A, Vick, Sarah C, Iglesia, Michael D, Brickey, W June, Midkiff, Bentley R, McKinnon, Karen P, Reisdorf, Shannon, Anders, Carey K, Carey, Lisa A, Parker, Joel S, Perou, Charles M, Vincent, Benjamin G, Serody, Jonathan S

“…Claudin-low breast cancer is an aggressive subtype that confers poor prognosis and is found largely within the clinical triple-negative group of breast cancer…”
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Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR by Deng, Meng, Guo, Haitao, Tam, Jason W, Johnson, Brandon M, Brickey, W June, New, James S, Lenox, Austin, Shi, Hexin, Golenbock, Douglas T, Koller, Beverly H, McKinnon, Karen P, Beutler, Bruce, Ting, Jenny P-Y

“…The role of lipids in inflammasome activation remains underappreciated. The phospholipid, platelet-activating factor (PAF), exerts multiple physiological…”
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Properly folded and functional PorB from Neisseria gonorrhoeae inhibits dendritic cell stimulation of CD4+ T cell proliferation by Zhu, Weiyan, Tomberg, Joshua, Knilans, Kayla J., Anderson, James E., McKinnon, Karen P., Sempowski, Gregory D., Nicholas, Robert A., Duncan, Joseph A.

“…Neisseria gonorrhoeae is an exclusive human pathogen that evades the host immune system through multiple mechanisms. We have shown that N. gonorrhoeae…”
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Concurrent Definitive Immunoradiotherapy for Patients with Stage III-IV Head and Neck Cancer and Cisplatin Contraindication by Weiss, Jared, Sheth, Siddharth, Deal, Allison M, Grilley Olson, Juneko E, Patel, Samip, Hackman, Trevor G, Blumberg, Jeffrey M, Galloway, Thomas J, Patel, Shetal, Zanation, Adam M, Shen, Colette J, Hayes, D Neil, Hilliard, Christopher, Mehra, Ranee, McKinnon, Karen P, Wang, Hsing-Hui, Weissler, Mark Christian, Bauman, Jessica R, Chera, Bhishamjit S, Vincent, Benjamin G

“…Although cisplatin plus radiotherapy is a standard treatment of locally advanced head and neck squamous cell carcinoma (LA-HNSCC), cisplatin contraindication…”
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Efficacy of a Dual-Epitope Dendritic Cell Vaccine as Part of Combined Immunotherapy for HER2-Expressing Breast Tumors by Vincent, Benjamin G, File, Danielle M, McKinnon, Karen P, Moore, Dominic T, Frelinger, Jeffrey A, Collins, Edward J, Ibrahim, Joseph G, Bixby, Lisa, Reisdorf, Shannon, Laurie, Sonia J, Park, Yara A, Anders, Carey K, Collichio, Frances A, Muss, Hyman B, Carey, Lisa A, van Deventer, Hendrik W, Dees, E Claire, Serody, Jonathan S

“…Previous work from our group and others has shown that patients with breast cancer can generate a T cell response against specific human epidermal growth…”
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Towards programming immune tolerance through geometric manipulation of phosphatidylserine by Roberts, Reid A, Eitas, Timothy K, Byrne, James D, Johnson, Brandon M, Short, Patrick J, McKinnon, Karen P, Reisdorf, Shannon, Luft, J.Christopher, DeSimone, Joseph M, Ting, Jenny P

“…Abstract The possibility of engineering the immune system in a targeted fashion using biomaterials such as nanoparticles has made considerable headway in…”
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Phase II Trial of Pembrolizumab after High-Dose Cytarabine in Relapsed/Refractory Acute Myeloid Leukemia by Zeidner, Joshua F, Vincent, Benjamin G, Ivanova, Anastasia, Moore, Dominic, McKinnon, Karen P, Wilkinson, Alec D, Mukhopadhyay, Rupkatha, Mazziotta, Francesco, Knaus, Hanna A, Foster, Matthew C, Coombs, Catherine C, Jamieson, Katarzyna, Van Deventer, Hendrik, Webster, Jonathan A, Prince, Gabrielle T, DeZern, Amy E, Smith, B Douglas, Levis, Mark J, Montgomery, Nathan D, Luznik, Leo, Serody, Jonathan S, Gojo, Ivana

“…Immune suppression, exhaustion, and senescence are frequently seen throughout disease progression in acute myeloid leukemia (AML). We conducted a phase II…”
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Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection by Callaway, Justin B., Smith, Scott A., McKinnon, Karen P., de Silva, Aravinda M., Crowe, James E., Ting, Jenny P.-Y.

“…Approximately 500,000 people are hospitalized with severe dengue illness annually. Antibody-dependent enhancement (ADE) of dengue virus (DENV) infection is…”
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Author Correction: Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy by Min, Yuanzeng, Roche, Kyle C., Tian, Shaomin, Eblan, Michael J., McKinnon, Karen P., Caster, Joseph M., Chai, Shengjie, Herring, Laura E., Zhang, Longzhen, Zhang, Tian, DeSimone, Joseph M., Tepper, Joel E., Vincent, Benjamin G., Serody, Jonathan S., Wang, Andrew Z.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41565-021-00864-w…”
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T-cell expression of AhR inhibits the maintenance of pTreg cells in the gastrointestinal tract in acute GVHD by Dant, Trisha A., Lin, Kaifeng L., Bruce, Danny W., Montgomery, Stephanie A., Kolupaev, Oleg V., Bommiasamy, Hemamalini, Bixby, Lisa M., Woosley, John T., McKinnon, Karen P., Gonzalez, Frank J., Blazar, Bruce R., Vincent, Benjamin G., Coghill, James M., Serody, Jonathan S.

“…The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that affects the function and development of immune cells. Here, we show that…”
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Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease by Wysocki, Christian A., Jiang, Qi, Panoskaltsis-Mortari, Angela, Taylor, Patricia A., McKinnon, Karen P., Su, Lishan, Blazar, Bruce R., Serody, Jonathan S.

“…CD4+CD25+ regulatory T cells (Tregs) have been shown to inhibit graft-versus-host disease (GVHD) in murine models, and this suppression was mediated by Tregs…”
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