Search Results - "McKinley, Jonathan"

Review of state-of-the-art micro and macro-bioreactors for the intervertebral disc by McKinley, Jonathan P., O'Connell, Grace D.

“…Lower back pain continues to be a global epidemic, limiting quality of life and ability to work, due in large part to symptomatic disc degeneration…”
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Dopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson’s Disease by McKinley, Jonathan W., Shi, Ziqing, Kawikova, Ivana, Hur, Matthew, Bamford, Ian J., Sudarsana Devi, Suma Priya, Vahedipour, Annie, Darvas, Martin, Bamford, Nigel S.

“…Motor and cognitive functions depend on the coordinated interactions between dopamine (DA) and acetylcholine (ACh) at striatal synapses. Increased ACh…”
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Large-scale quantification of human osteocyte lacunar morphological biomarkers as assessed by ultra-high-resolution desktop micro-computed tomography by Goff, Elliott, Buccino, Federica, Bregoli, Chiara, McKinley, Jonathan P., Aeppli, Basil, Recker, Robert R., Shane, Elizabeth, Cohen, Adi, Kuhn, Gisela, Müller, Ralph

“…Ultra-high-resolution imaging of the osteocyte lacuno-canalicular network (LCN) three-dimensionally (3D) in a high-throughput fashion has greatly improved the…”
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Design of a flexing organ-chip to model in situ loading of the intervertebral disc by McKinley, Jonathan P., Montes, Andre R., Wang, Maple N., Kamath, Anuya R., Jimenez, Gissell, Lim, Jianhua, Marathe, Siddharth A., Mofrad, Mohammad R. K., O’Connell, Grace D.

“…The leading cause of disability of all ages worldwide is severe lower back pain. To address this untreated epidemic, further investigation is needed into the…”
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Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice by Shi, Ziqing, Bamford, Ian J, McKinley, Jonathan W, Devi, Suma Priya Sudarsana, Vahedipour, Annie, Bamford, Nigel S

“…Parkinsonism is caused by dopamine (DA) insufficiency and results in a hypokinetic movement disorder. Treatment with L-Dopa can restore DA availability and…”
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Loss of glutamate signaling from the thalamus to dorsal striatum impairs motor function and slows the execution of learned behaviors by Melief, Erica J., McKinley, Jonathan W., Lam, Jonathan Y., Whiteley, Nicole M., Gibson, Alec W., Neumaier, John F., Henschen, Charles W., Palmiter, Richard D., Bamford, Nigel S., Darvas, Martin

“…Parkinson’s disease (PD) is primarily associated with the degeneration of midbrain dopamine neurons, but it is now appreciated that pathological processes like…”
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Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice(1,2,3) by Storey, Granville P, Gonzalez-Fernandez, Gabriel, Bamford, Ian J, Hur, Matthew, McKinley, Jonathan W, Heimbigner, Lauren, Minasyan, Ani, Walwyn, Wendy M, Bamford, Nigel S

“…Corticostriatal signaling participates in sensitized responses to drugs of abuse, where short-term increases in dopamine availability provoke persistent, yet…”
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Striatal Acetylcholine and Dopamine are Necessary for Motor Function in Parkinsonism (P5.8-001) by Bamford, Nigel, McKinley, Jonathan, Shi, Ziqing

“…Abstract only…”
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L-Dopa-Induced Dyskinesias are Reduced by Propranolol in Parkinsonian Mice (P5.8-002) by Bamford, Nigel, Shi, Ziqing, Bamford, Ian, Mckinley, Jonathan

“…Abstract only…”
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Impactful Design: From Microfluidic Devices for Modeling the Spine to Equipment for Pandemic Relief by McKinley, Jonathan Patrick

“…Lower back pain is the leading cause of physical disability worldwide. In the United States, annual costs associated with lower back pain exceed $100 billion,…”
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Designing a breast support device for phase contrast tomographic imaging: getting ready for a clinical trial by Dimmock, Matthew, McKinley, Jonathan, Massey, Adrian, Hausermann, Daniel, Tam, Nathan, Stewart, Elizabeth, Cowling, Cynthia, Sim, Jenny, Brennan, Patrick C, Gureyev, Timur, Taba, Seyedamir Tavakoli, Schultz-Ferguson, Cindy, Jimenez, Yobelli A, Lewis, Sarah Jayne

“…To design a device that can support the breast during phase-contrast tomography, and characterise its fit parameterisation and comfort rating. 27 participants…”
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Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice123 by Storey, Granville P., Gonzalez-Fernandez, Gabriel, Bamford, Ian J., Hur, Matthew, McKinley, Jonathan W., Heimbigner, Lauren, Minasyan, Ani, Walwyn, Wendy M., Bamford, Nigel S.

“…Corticostriatal signaling participates in sensitized responses to drugs of abuse, where short-term increases in dopamine availability provoke persistent, yet…”
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An interchangeable surgical instrument system with application to supervised automation of multilateral tumor resection by McKinley, Stephen, Garg, Animesh, Sen, Siddarth, Gealy, David V., McKinley, Jonathan P., Yiming Jen, Menglong Guo, Boyd, Doug, Goldberg, Ken

“…Many surgical procedures require a sequence of different end-effectors but switching tools for robot-assisted minimally-invasive surgery (RMIS) requires…”
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