Search Results - "McKinlay, MA"

New insights into physiopathology of immunodeficiency-associated vaccine-derived poliovirus infection; systematic review of over 5 decades of data by Shaghaghi, Mohammadreza, Soleyman-jahi, Saeed, Abolhassani, Hassan, Yazdani, Reza, Azizi, Gholamreza, Rezaei, Nima, Barbouche, Mohamed-Ridha, McKinlay, Mark A., Aghamohammadi, Asghar

“…•Inherent features of PID contribute to manifestations and outcome of polio infection.•Cytotoxic cellular mechanisms may contribute to the development of…”
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Relationship of Pleconaril Susceptibility and Clinical Outcomes in Treatment of Common Colds Caused by Rhinoviruses by PEVEAR, Daniel C, HAYDEN, Frederick G, DEMENCZUK, Tina M, BARONE, Linda R, MCKINLAY, Mark A, COLLETT, Marc S

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Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-[kappa]B signaling by degrading TRAF2-associated cIAP1 in cancer cells by Mitsuuchi, Y, Benetatos, Ca, Deng, Y, Haimowitz, T, Beck, Sc, Arnone, Mr, Kapoor, Gs, Seipel, Me, Chunduru, Sk, Mckinlay, Ma, Begley, Cg, Condon, Sm

“…The inhibitor of apoptosis (IAP) proteins have pivotal roles in cell proliferation and differentiation, and antagonizing IAPs in certain cancer cell lines…”
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Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-κB signaling by degrading TRAF2-associated cIAP1 in cancer cells by Mitsuuchi, Y, Benetatos, CA, Deng, Y, Haimowitz, T, Beck, SC, Arnone, MR, Kapoor, GS, Seipel, ME, Chunduru, SK, McKinlay, MA, Begley, CG, Condon, SM

“…The inhibitor of apoptosis (IAP) proteins have pivotal roles in cell proliferation and differentiation, and antagonizing IAPs in certain cancer cell lines…”
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Enterovirus Meningitis in Adults by Rotbart, Harley A., Brennan, P. J., Fife, Kenneth H., Romero, Jose R., Griffin, Johanna A., McKinlay, Mark A., Hayden, Frederick G.

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The structure of human rhinovirus 16 by Oliveira, M A, Zhao, R, Lee, W M, Kremer, M J, Minor, I, Rueckert, R R, Diana, G D, Pevear, D C, Dutko, F J, McKinlay, M A

“…Rhinoviruses and the homologous polioviruses have hydrophobic pockets below their receptor-binding sites, which often contain unidentified electron density…”
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Treatment of human enterovirus infections by Rotbart, Harley A, O'Connell, John F, McKinlay, Mark A

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Treatment of the Picornavirus common cold by inhibitors of viral uncoating and attachment by MCKINLAY, M. A, PEVEAR, D. C, ROSSMAN, M. G

“…The human rhinoviruses are the leading cause of the ubiquitous, mild, and self-limiting infections generally referred to as the common cold. Considerable…”
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The Site of Attachment in Human Rhinovirus 14 for Antiviral Agents that Inhibit Uncoating by Smith, Thomas J., Kremer, Marcia J., Luo, Ming, Vriend, Gerrit, Arnold, Edward, Kamer, Greg, Rossmann, Michael G., McKinlay, Mark A., Diana, Guy D., Otto, Michael J.

“…WIN 51711 and WIN 52084 are structurally related, antiviral compounds that inhibit the replication of rhino (common cold) viruses and related picornaviruses…”
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Crystal structure of human rhinovirus serotype 1A (HRV1A) by Kim, S S, Smith, T J, Chapman, M S, Rossmann, M C, Pevear, D C, Dutko, F J, Felock, P J, Diana, G D, McKinlay, M A

“…The structure of human rhinovirus 1A (HRV1A) has been determined to 3.2 A resolution using phase refinement and extension by symmetry averaging starting with…”
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Social learning, shared accommodation and interprofessional education: I think those conversations that you have at the dinner table by McKinlay, Eileen, MA(App), RN, Gallagher, Peter, PhD, RN, Wilson, Christine, BComm, DipBus, Gray, Lesley, MPH, MSc, McHugh, Patrick, BMS, MBChB, Pullon, Sue, MPHC, MBChB

“…Abstract Background Little is known about the impact of social or informal learning and whether or not this influences the outcomes of formal IPE learning…”
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A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A by Kim, K H, Willingmann, P, Gong, Z X, Kremer, M J, Chapman, M S, Minor, I, Oliveira, M A, Rossmann, M G, Andries, K, Diana, G D

“…The three-dimensional structures of two human rhinovirus serotypes (HRV14 and HRV1A) are compared when complexed with various antiviral agents. Although these…”
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Conformational change in the floor of the human rhinovirus canyon blocks adsorption to HeLa cell receptors by PEVEAR, D. C, FANCHER, M. J, FELOCK, P. J, ROSSMANN, M. G, MILLER, M. S, DIANA, G, TREASURYWALA, A. M, MCKINLAY, M. A, DUTKO, F. J

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Structural Analysis of a Series of Antiviral Agents Complexed with Human Rhinovirus 14 by Badger, John, Minor, Iwona, Kremer, Marcia J., Oliveira, Marcos A., Smith, Thomas J., Griffith, James P., Diego M. A. Guerin, Krishnaswamy, S., Luo, Ming, Rossmann, Michael G., McKinlay, Mark A., Diana, Guy D., Dutko, Frank J., Fancher, Marilyn, Rueckert, Roland R., Heinz, Beverly A.

“…The binding to human rhinovirus 14 of a series of eight antiviral agents that inhibit picornaviral uncoating after entry into host cells has been characterized…”
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Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug by FOX, M. P, OTTO, M. J, MCKINLAY, M. A

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Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound by HEINZ, B. A, RUECKERT, R. R, SHEPARD, D. A, DUTKO, F. J, MCKINLAY, M. A, FANCHER, M, ROSSMANN, M. G, BADGER, J, SMITH, T. J

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Human rhinovirus 14 complexed with fragments of active antiviral compounds by Bibler-Muckelbauer, J K, Kremer, M J, Rossmann, M G, Diana, G D, Dutko, F J, Pevear, D C, McKinlay, M A

“…Crystallographic studies of human rhinovirus 14 (HRV14) crystals soaked with fragments of antiviral WIN compounds, at high concentrations (82-200…”
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[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating by Diana, G. D, McKinlay, M. A, Otto, M. J, Akullian, V, Oglesby, C

“…A series of [[(4,5-dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles has been synthesized and evaluated as antipicornavirus agents. The effect of alkyl groups in the…”
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Binding affinities of structurally related human rhinovirus capsid-binding compounds are related to their activities against human rhinovirus type 14 by FOX, M. P, MCKINLAY, M. A, DIANA, G. D, DUTKO, F. J

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Inhibition of poliovirus uncoating by disoxaril (WIN 51711) by Zeichhardt, H, Otto, M J, McKinlay, M A, Willingmann, P, Habermehl, K O

“…Disoxaril [WIN 51711, 5-[7-[4(4,5-dihydro-2-oxazolyl)phenoxy]heptyl]-3- methylisoxazole] inhibits the replication of polioviruses types 1 and 2 in HeLa cells…”
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