Search Results - "McKim, Kim S."

Sister centromere fusion during meiosis I depends on maintaining cohesins and destabilizing microtubule attachments by Wang, Lin-Ing, Das, Arunika, McKim, Kim S

“…Sister centromere fusion is a process unique to meiosis that promotes co-orientation of the sister kinetochores, ensuring they attach to microtubules from the…”
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Dynamic and Stable Cohesins Regulate Synaptonemal Complex Assembly and Chromosome Segregation by Gyuricza, Mercedes R., Manheimer, Kathryn B., Apte, Vandana, Krishnan, Badri, Joyce, Eric F., McKee, Bruce D., McKim, Kim S.

“…Assembly of the synaptonemal complex (SC) in Drosophila depends on two independent pathways defined by the chromosome axis proteins C(2)M and ORD. Because…”
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A Pathway for Synapsis Initiation during Zygotene in Drosophila Oocytes by Tanneti, Nikhila S., Landy, Kathryn, Joyce, Eric F., McKim, Kim S.

“…Formation of the synaptonemal complex (SC), or synapsis, between homologs in meiosis is essential for crossing over and chromosome segregation [1–4]. How SC…”
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A dynamic population of prophase CENP-C is required for meiotic chromosome segregation by Fellmeth, Jessica E, Jang, Janet K, Persaud, Manisha, Sturm, Hannah, Changela, Neha, Parikh, Aashka, McKim, Kim S

“…The centromere is an epigenetic mark that is a loading site for the kinetochore during meiosis and mitosis. This mark is characterized by the H3 variant…”
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Whole transcriptome screening for novel genes involved in meiosis and fertility in Drosophila melanogaster by Sun, Siqi, Defosse, Tyler, Boyd, Ayla, Sop, Joel, Verderose, Faith, Surray, Diya, Aziz, Mark, Howland, Margaret, Wu, Siwen, Changela, Neha, Jang, Janet, Schindler, Karen, Xing, Jinchuan, McKim, Kim S.

“…Reproductive success requires the development of viable oocytes and the accurate segregation of chromosomes during meiosis. Failure to segregate chromosomes…”
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Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes by Radford, Sarah J, Hoang, Tranchau L, Głuszek, A Agata, Ohkura, Hiroyuki, McKim, Kim S

“…In oocytes, where centrosomes are absent, the chromosomes direct the assembly of a bipolar spindle. Interactions between chromosomes and microtubules are…”
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Meiotic CENP-C is a shepherd: bridging the space between the centromere and the kinetochore in time and space by Fellmeth, Jessica E, McKim, Kim S

“…While many of the proteins involved in the mitotic centromere and kinetochore are conserved in meiosis, they often gain a novel function due to the unique…”
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The chromosomal basis of meiotic acentrosomal spindle assembly and function in oocytes by Radford, Sarah J., Nguyen, Alexandra L., Schindler, Karen, McKim, Kim S.

“…Several aspects of meiosis are impacted by the absence of centrosomes in oocytes. Here, we review four aspects of meiosis I that are significantly affected by…”
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Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair by Joyce, Eric F, Pedersen, Michael, Tiong, Stanley, White-Brown, Sanese K, Paul, Anshu, Campbell, Shelagh D, McKim, Kim S

“…Ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-related (ATR) kinases are conserved regulators of cellular responses to double strand breaks…”
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The chromosomal passenger complex is required for meiotic acentrosomal spindle assembly and chromosome biorientation by Radford, Sarah J, Jang, Janet K, McKim, Kim S

“…During meiosis in the females of many species, spindle assembly occurs in the absence of the microtubule-organizing centers called centrosomes. In the absence…”
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Cooperation Between Kinesin Motors Promotes Spindle Symmetry and Chromosome Organization in Oocytes by Radford, Sarah J, Go, Allysa Marie M, McKim, Kim S

“…The oocyte spindle in most animal species is assembled in the absence of the microtubule-organizing centers called centrosomes. Without the organization…”
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Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster by Lake, Cathleen M, Nielsen, Rachel J, Bonner, Amanda M, Eche, Salam, White-Brown, Sanese, McKim, Kim S, Hawley, R Scott

“…Meiotic recombination, which is necessary to ensure that homologous chromosomes segregate properly, begins with the induction of meiotic DNA double-strand…”
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Chromosome axis defects induce a checkpoint-mediated delay and interchromosomal effect on crossing over during Drosophila meiosis by Joyce, Eric F, McKim, Kim S

“…Crossovers mediate the accurate segregation of homologous chromosomes during meiosis. The widely conserved pch2 gene of Drosophila melanogaster is required for…”
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The microtubule catastrophe promoter Sentin delays stable kinetochore-microtubule attachment in oocytes by Głuszek, A Agata, Cullen, C Fiona, Li, Wenjing, Battaglia, Rachel A, Radford, Sarah J, Costa, Mariana F, McKim, Kim S, Goshima, Gohta, Ohkura, Hiroyuki

“…The critical step in meiosis is to attach homologous chromosomes to the opposite poles. In mouse oocytes, stable microtubule end-on attachments to kinetochores…”
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Microtubule-depolymerizing kinesin KLP10A restricts the length of the acentrosomal meiotic spindle in Drosophila females by Radford, Sarah J, Harrison, Andrew M, McKim, Kim S

“…During cell division, a bipolar array of microtubules forms the spindle through which the forces required for chromosome segregation are transmitted…”
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Highway to hell‐thy meiotic divisions: Chromosome passenger complex functions driven by microtubules: CPC interactions with both the chromosomes and microtubules are important for spindle assembly and function by McKim, Kim S.

“…Abstract The chromosome passenger complex (CPC) localizes to chromosomes and microtubules, sometimes simultaneously. The CPC also has multiple domains for…”
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Kinesin 6 Regulation in Drosophila Female Meiosis by the Non-conserved N- and C- Terminal Domains by Das, Arunika, Cesario, Jeffry, Hinman, Anna Maria, Jang, Janet K, McKim, Kim S

“…Bipolar spindle assembly occurs in the absence of centrosomes in the oocytes of most organisms. In the absence of centrosomes in oocytes, we have proposed that…”
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Relationship of DNA double-strand breaks to synapsis in Drosophila by Jang, Janet K, Sherizen, Dalia E, Bhagat, Rajal, Manheim, Elizabeth A, McKim, Kim S

“…The relationship between synaptonemal complex formation (synapsis) and double-strand break formation (recombination initiation) differs between organisms…”
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Juxtaposition of C(2)M and the transverse filament protein C(3)G within the central region of Drosophila synaptonemal complex by Anderson, L.K, Royer, S.M, Page, S.L, McKim, K.S, Lai, A, Lilly, M.A, Hawley, R.S

“…The synaptonemal complex (SC) is intimately involved in the process of meiotic recombination in most organisms, but its exact role remains enigmatic. One…”
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The Synaptonemal Complex Component C(2)M Regulates Meiotic Crossing over in Drosophila by Manheim, Elizabeth A., McKim, Kim S.

“…Background: The synaptonemal complex (SC) is a proteinaceous structure that forms between homologously paired meiotic chromosomes. Previous studies have…”
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