Search Results - "McKim, J.M."

A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish by Nichols, J W, McKim, J M, Andersen, M E, Gargas, M L, Clewell, 3rd, H J, Erickson, R J

“…A physiologically based toxicokinetic model was developed to predict the uptake and disposition of waterborne organic chemicals in fish. The model consists of…”
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Differential expression of the metallothionein gene in liver and brain of mice and rats by Choudhuri, S, McKim, Jr, J M, Klaassen, C D

“…Expression of the metallothionein I (MT-I) gene was studied in liver and brain of control mice and rats, as well as following administration of Cd and…”
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In vitro human skin irritation test for evaluation of medical device extracts by Casas, J.W., Lewerenz, G.M., Rankin, E.A., Willoughby, J.A., Blakeman, L.C., McKim, J.M., Coleman, K.P.

“…•Extracts of medical device materials were tested for skin irritation potential.•These extracts were spiked with the skin irritants lactic acid and heptanoic…”
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Induction of metallothionein by diethyl maleate by Bauman, J W, McKim, Jr, J M, Liu, J, Klaassen, C D

“…Metallothionein (MT) is a sulfhydryl-rich protein whose levels are increased by administration of a variety of agents including metals, cytokines, and…”
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Dose determinations for waterborne 2,5,2',5'-[14C]tetrachlorobiphenyl and related pharmacokinetics in two species of trout (Salmo gairdneri and Salvelinus fontinalis): a mass-balance approach by McKim, J M, Heath, E M

“…A mass-balance study was undertaken to evaluate the accuracy of dose determinations of waterborne 2,5,2',5'-[14C]tetrachlorobiphenyl (TCB) made on transected…”
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Fish Acute Toxicity Syndromes and Their Use in the QSAR Approach to Hazard Assessment by McKim, James M., Bradbury, Steven P., Niemi, Gerald J.

“…Implementation of the Toxic Substances Control Act of 1977 creates the need to reliably establish testing priorities because laboratory resources are limited…”
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Induction of hepatic phase I and phase II metabolizing enzymes in the female fischer 344 rat by cyclicsiloxanes by McKim, J.M., Wilga, P.C., Kolesar, G.B., Dochterman, L.W., Madan, A., Parkinson, A., Meeks, R.G.

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Physiologically based toxicokinetic modeling of three waterborne chloroethanes in rainbow trout (Oncorhynchus mykiss) by Nichols, J W, McKim, J M, Lien, G J, Hoffman, A D, Bertelsen, S L

“…A physiologically based toxicokinetic model for fish was used to simulate the uptake and disposition of three waterborne chloroethanes in rainbow trout…”
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Induction of hepatic metallothionein by paraquat by Bauman, J W, Madhu, C, McKim, Jr, J M, Liu, Y, Klaassen, C D

“…Paraquat, a frequently used contact herbicide, produces oxidative stress by undergoing redox cycling and generating reactive oxygen species. Paraquat is also…”
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Distribution of cadmium chloride and cadmium-metallothionein to liver parenchymal, Kupffer, and endothelial cells: their relative ability to express metallothionein by McKim, Jr, J M, Liu, J, Liu, Y P, Klaassen, C D

“…Acute exposure to cadmium (Cd) salts results in liver toxicity, while administration of cadmium-metallothionein (CdMT) iv, causes renal damage. When CdMT is…”
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Induction of metallothionein by cadmium-metallothionein in rat liver: a proposed mechanism by McKim, Jr, J M, Liu, J, Liu, Y P, Klaassen, C D

“…Distribution of Cd to various organs following iv administration of CdCl2 (3.5 mg Cd/kg) resulted in more than 43% of total tissue Cd accumulating in the…”
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Alterations of hepatic acetyl-CoA carboxylase by 2,3,7,8-tetrachlorodibenzo-p-dioxin by McKim, J.M Jr. (Oregon State University, Corvallis, OR), Marien, K, Schaup, H.W, Selivonchick, D.P

“…The effect of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) on acetyl‐CoA carboxylase (ACC) activity and synthesis was examined. Male Wistar rats received a…”
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High-performance liquid chromatographic determination of glycyrrhizin in licorice products by Hurst, W. Jeffrey, McKim, J. Michael, Martin, Robert A

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Changes in the blood of the brown bullhead (Ictalurus nebulosus (Lesueur)) following short and long term exposure to copper(II) by Christensen, G M, McKim, J M, Brungs, W A, Hunt, E P

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Water pollution--effects of pollution on fresheater fish by McKim, J.M, Benott, D.A, Biesinger, K.E, Brungs, W.A, Siefert, R.E

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