Search Results - "McKim, J M"

In vitro human skin irritation test for evaluation of medical device extracts by Casas, J.W., Lewerenz, G.M., Rankin, E.A., Willoughby, J.A., Blakeman, L.C., McKim, J.M., Coleman, K.P.

“…•Extracts of medical device materials were tested for skin irritation potential.•These extracts were spiked with the skin irritants lactic acid and heptanoic…”
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Potential Estrogenic and Antiestrogenic Activity of the Cyclic Siloxane Octamethylcyclotetrasiloxane (D4) and the Linear Siloxane Hexamethyldisiloxane (HMDS) in Immature Rats Using the Uterotrophic Assay by McKim, James M., Wilga, Paul C., Breslin, William J., Plotzke, Kathy P., Gallavan, Robert H., Meeks, Robert G.

“…The cyclic siloxane octamethylcyclotetrasiloxane (D4) and the linear siloxane hexamethyldisiloxane (HMDS) have numerous industrial and consumer applications…”
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Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids by Sokol, R J, Winklhofer-Roob, B M, Devereaux, M W, McKim, Jr, J M

“…The mechanisms causing liver injury in cholestatic diseases are unclear. The hypothesis that accumulation of hydrophobic bile acids in hepatocytes during…”
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Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat by Sokol, Ronald J., McKim, James M., Goff, M.Colby, Ruyle, Stephanie Z., Devereaux, Michael W., Han, Derick, Packer, Lester, Everson, Gregory

“…Background & Aims: Hydrophobic bile acids have been implicated in the pathogenesis of cholestatic liver injury. The hypothesis that hydrophobic bile acid…”
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Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis by Sokol, R J, Twedt, D, McKim, Jr, J M, Devereaux, M W, Karrer, F M, Kam, I, von Steigman, G, Narkewicz, M R, Bacon, B R, Britton, R S

“…Copper overload leads to liver injury in humans with Wilson's disease and in Bedlington terriers with copper toxicosis; however, the mechanisms of liver injury…”
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Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5) by MCKIM, J. M, CHOUDHURI, S, WILGA, P. C, MADAN, A, BURNS-NAAS, L. A, GALLAVAN, R. H, MAST, R. W, NAAS, D. J, PARKINSON, A, MEEKS, R. G

“…Decamethylcyclopentasiloxane (D5) is a cyclic siloxane with a wide range of commercial applications. The present study was designed to investigate the effects…”
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Repeated Inhalation Exposure to Octamethylcyclotetrasiloxane Produces Hepatomegaly, Transient Hepatic Hyperplasia, and Sustained Hypertrophy in Female Fischer 344 Rats in a Manner Similar to Phenobarbital by McKim, James M., Kolesar, Gary B., Jean, Paul A., Meeker, Linda S., Wilga, Paul C., Schoonhoven, Robert, Swenberg, James A., Goodman, Jay I., Gallavan, Robert H., Meeks, Robert G.

“…Octamethylcyclotetrasiloxane (D4) has been described as a phenobarbital-like inducer of hepatic enzymes. Phenobarbital (PB) and phenobarbital-like chemicals…”
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In Vitro and In Vivo Studies on the Degradation of Metallothionein by Klaassen, Curtis D., Choudhuri, Supratim, McKim, James M., Lehman-McKeeman, Lois D., Kershaw, William C.

“…Degradation of metallothionein (MT) from rat liver was examined. Degradation of apo-MT by liver homogenate was greater than that by cytosol. At pH 5.5,…”
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Differential expression of the metallothionein gene in liver and brain of mice and rats by Choudhuri, S, McKim, Jr, J M, Klaassen, C D

“…Expression of the metallothionein I (MT-I) gene was studied in liver and brain of control mice and rats, as well as following administration of Cd and…”
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Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study by McKim, Jr, J M, Wilga, P C, Kolesar, G B, Choudhuri, S, Madan, A, Dochterman, L W, Breen, J G, Parkinson, A, Mast, R W, Meeks, R G

“…Repeated inhalation exposure to octamethylcyclotetrasiloxane (D4) produces a reversible and dose-related hepatomegaly and proliferation of hepatic endoplasmic…”
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Induction of metallothionein by diethyl maleate by Bauman, J W, McKim, Jr, J M, Liu, J, Klaassen, C D

“…Metallothionein (MT) is a sulfhydryl-rich protein whose levels are increased by administration of a variety of agents including metals, cytokines, and…”
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Induction of hepatic metallothionein by paraquat by Bauman, J W, Madhu, C, McKim, Jr, J M, Liu, Y, Klaassen, C D

“…Paraquat, a frequently used contact herbicide, produces oxidative stress by undergoing redox cycling and generating reactive oxygen species. Paraquat is also…”
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Distribution of cadmium chloride and cadmium-metallothionein to liver parenchymal, Kupffer, and endothelial cells: their relative ability to express metallothionein by McKim, Jr, J M, Liu, J, Liu, Y P, Klaassen, C D

“…Acute exposure to cadmium (Cd) salts results in liver toxicity, while administration of cadmium-metallothionein (CdMT) iv, causes renal damage. When CdMT is…”
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Dynamics of renal excretion of phenol and major metabolites in the rainbow trout ( Oncorhynchus mykiss) by McKim, James M., Kolanczyk, Richard C., Lien, Gregory J., Hoffman, Alex D.

“…Renal excretion of phenol (PH), phenyl glucuronide (PG), phenyl sulfate (PS), and hydroquinone (HQ) was determined in 600–900 g rainbow trout ( Oncorhynchus…”
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A physiologically based toxicokinetic model for the uptake and disposition of waterborne organic chemicals in fish by Nichols, J W, McKim, J M, Andersen, M E, Gargas, M L, Clewell, 3rd, H J, Erickson, R J

“…A physiologically based toxicokinetic model was developed to predict the uptake and disposition of waterborne organic chemicals in fish. The model consists of…”
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Induction of metallothionein by cadmium-metallothionein in rat liver: a proposed mechanism by McKim, Jr, J M, Liu, J, Liu, Y P, Klaassen, C D

“…Distribution of Cd to various organs following iv administration of CdCl2 (3.5 mg Cd/kg) resulted in more than 43% of total tissue Cd accumulating in the…”
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Effects of anesthesia (tricaine methanesulfonate, MS222) on liver biotransformation in rainbow trout ( Oncorhynchus mykiss) by Kolanczyk, Richard C, Fitzsimmons, Patrick N, McKim, James M, Erickson, Russell J, Schmieder, Patricia K

“…The effect of tricaine methanesulfonate (MS222) on rainbow trout liver biotransformation rates was investigated with a microsomal model; an in vitro…”
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Role of hepatic lysosomes in the degradation of metallothionein by Choudhuri, S, McKim, Jr, J M, Klaassen, C D

“…The degradation of metallothionein (MT) by rat liver was examined. Degradation of MT by liver homogenate was greater than by cytosol. In addition, MT…”
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Induction of metallothionein by superantigenic bacterial exotoxin: probable involvement of the immune system by Choudhuri, S, McKim, Jr, J M, Klaassen, C D

“…Metallothionein (MT) can be induced in mouse liver by a bacterial exotoxin, toxic shock syndrome toxin-1 (TSST-1). Hepatic MT was induced by TSST-1 in a…”
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In vitro degradation of apo-, zinc-, and cadmium-metallothionein by cathepsins B, C, and D by McKim, Jr, J M, Choudhuri, S, Klaassen, C D

“…Metallothionein (MT) has been extensively studied over the past several years because of its probable role in endogenous metal homeostasis and cellular…”
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