Search Results - "McKerrow, J.H"

The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi by Eakin, A E, Mills, A A, Harth, G, McKerrow, J H, Craik, C S

“…The complete sequence of the gene encoding the major cysteine protease from Trypanosoma cruzi is reported. The amino acid sequence predicted from the gene…”
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Cysteine proteases of parasitic organisms by Sajid, M., McKerrow, J.H.

“…Cysteine proteases play numerous indispensable roles in the biology of parasitic organisms. Aside from previously known general catabolic functions and protein…”
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Two Approaches to Discovering and Developing New Drugs for Chagas Disease by McKerrow, J.H, Doyle, P.S, Engel, J.C, Podust, L.M, Robertson, S.A, Ferreira, R, Saxton, T, Arkin, M, Kerr, I.D, Brinen, L.S, Craik, C.S

“…This review will focus on two general approaches carried out at the Sandler Center, University of California, San Francisco, to address the challenge of…”
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A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling by Guiliano, David B., Hong, Xiqiang, McKerrow, James H., Blaxter, Mark.L., Oksov, Yelena, Liu, Jing, Ghedin, Elodie, Lustigman, Sara

“…Cysteine proteinases are involved in a variety of important biological processes and have been implicated in molting and tissue remodeling in free living and…”
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Erratum to “Cysteine proteases of parasitic organisms”: [Mol. Biochem. Parasitol. 120 (2002) 1–21] by Sajid, M., McKerrow, J.H.

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Leishmania tropica: cysteine proteases are essential for growth and pathogenicity by Mahmoudzadeh-Niknam, H., McKerrow, J.H.

“…Leishmania parasites are responsible for a diverse collection of diseases of humans and other animals. Cysteine proteases are putative virulence factors of…”
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Characterization of immunoglobulin binding by schistosomes by MCINTOSH, R.S, JONES, F.M, DUNNE, D.W, MCKERROW, J.H, PLEASS, R.J

“…Although controversial, schistosomes are believed to cloak themselves in antibody through non-specific interactions with the immunoglobulin (Ig) molecule. The…”
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Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus by LUSTIGMAN, S, BROTMAN, B, HUIMA, T, PRINCE, A. M, PRINCE, A. M, MCKERROW, J. H

“…A cDNA clone designated OV7 encodes a polypeptide that corresponds to a highly antigenic Onchocerca volvulus protein. OV7 has significant amino acid sequence…”
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Cysteine proteinase inhibitors kill cultured bloodstream forms of Trypanosoma brucei brucei by Troeberg, L, Morty, R.E, Pike, R.N, Lonsdale-Eccles, J.D, Palmer, J.T, McKerrow, J.H, Coetzer, T.H.T

“…Trypanosoma brucei brucei is a causative agent of bovine trypanosomiasis (nagana), a disease of considerable economic significance in much of Africa. Here we…”
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Identification of promoter elements of parasitic nematode genes in transgenic Caenorhabditis elegans by Britton, C, Redmond, D.L, Knox, D.P, McKerrow, J.H, Barry, J.D

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Gut-specific and developmental expression of a Caenorhabditis elegans cysteine protease gene by Ray, C, McKerrow, J H

“…A Caenorhabditis elegans cysteine protease gene fragment, amplified by PCR using conserved eukaryotic protease gene sequences as primers, was used as a probe…”
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Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi by EAKIN, A. E, MCGRATH, M. E, MCKERROW, J. H, FLETTERICK, R. J, CRAIK, C. S

“…The major cysteine protease of Trypanosoma cruzi, cruzain, has been previously expressed in Escherichia coli as a fusion polypeptide. The proteolytic…”
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Schistosoma mansoni:Evidence for a 28-kDa Membrane-Anchored Protease on Schistosomula by Ghendler, Y., Parizade, M., Arnon, R., McKerrow, J.H., Fishelson, Z.

“…Transformation of cercariae ofSchistosoma mansoniinto schistosomula is accompanied by release of a soluble 28-kDa serine protease (s28) from the acetabular…”
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Partial characterization of the proteolytic secretions of Acanthamoeba polyphaga by Mitro, K, Bhagavathiammai, A, Zhou, O M, Bobbett, G, McKerrow, J H, Chokshi, R, Chokshi, B, James, E R

“…The ocular pathology associated with acanthamoebiasis may result, at least in part, from the excretory and secretory (E&S) products of the active Acanthamoeba…”
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Ss40: The Zinc Endopeptidase Secreted by Infective Larvae of Strongloides stercoralis by Brindley, P.J., Gam, A.A., Mckerrow, J.H., Neva, F.A.

“…Infective larvae of a pathogenic nematode of humans, Strongyloides stercoralis, release a potent zinc endopeptidase activity which has a broad substrate…”
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Brugia pahangi: identification and characterization of an aminopeptidase associated with larval molting by Hong, X, Bouvier, J, Wong, M M, Yamagata, G Y, McKerrow, J H

“…The third-stage larvae (L3) of the filarid parasite Brugia pahangi were surveyed for protease activity beginning with release from the mosquito vector through…”
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Human fibroblast collagenase contains an amino acid sequence homologous to the zinc-binding site of Serratia protease by McKerrow, J.H.

“…Analysis of sequence alignments between the recently published sequence of human fibroblast collagenase and a computer file of published protease sequences has…”
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Simulium damnosum s.l.: isolation and identification of prophenoloxidase following and infection with Onchocerca spp. using targeted differential display by Hagen, H.E. (Keele University, Staffordshire, UK.), Klager, S.L, McKerrow, J.H, Ham, P.J

“…Phenoloxidase (PO) is the key enzyme for melanin synthesis and plays an important role in the defense and recognition of pathogens in insects and other…”
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Simulium damnosum s.I.: Identification of Inducible Serine Proteases Following an Onchocerca Infection by Differential Display Reverse Transcription PCR by Hagen, H.E., Klager, S.L., Chan, V., Sakanari, J.A., Mckerrow, J.H., Ham, P.J.

“…Vector-derived proteases are thought to be key to the regulation of filarial infections in Simulium damnosum s.l. To identify proteases of S. damnosum s.l…”
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Purification and characterization of major extracellular proteinases from Trichophyton rubrum by Asahi, M, Lindquist, R, Fukuyama, K, Apodaca, G, Epstein, W.L, McKerrow, J.H

“…Two extracellular proteinases that probably play a central role in the metabolism and pathogenesis of the most common dermatophyte of man, Trichophyton rubrum,…”
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