Search Results - "McKernan, Kaitlin"

Interplay of BAF and MLL4 promotes cell type-specific enhancer activation by Park, Young-Kwon, Lee, Ji-Eun, Yan, Zhijiang, McKernan, Kaitlin, O’Haren, Tommy, Wang, Weidong, Peng, Weiqun, Ge, Kai

“…Cell type-specific enhancers are activated by coordinated actions of lineage-determining transcription factors (LDTFs) and chromatin regulators. The SWI/SNF…”
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Female adipose tissue has improved adaptability and metabolic health compared to males in aged obesity by Varghese, Mita, Griffin, Cameron, McKernan, Kaitlin, Eter, Leila, Abrishami, Simin, Singer, Kanakadurga

“…Aging, like obesity, is associated with metabolic and inflammatory alterations within adipose tissue in older individuals. Younger females are protected from…”
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Androgen signaling restricts glutaminolysis to drive sex-specific Th17 metabolism in allergic airway inflammation by Chowdhury, Nowrin U, Cephus, Jacqueline-Yvonne, Henriquez Pilier, Emely, Wolf, Melissa M, Madden, Matthew Z, Kuehnle, Shelby N, McKernan, Kaitlin E, Jennings, Erin Q, Arner, Emily N, Heintzman, Darren R, Chi, Channing, Sugiura, Ayaka, Stier, Matthew T, Voss, Kelsey, Ye, Xiang, Scales, Kennedi L, Krystofiak, Evan S, Gandhi, Vivek D, Guzy, Robert D, Cahill, Katherine N, Sperling, Anne I, Peebles, Jr, R Stokes, Rathmell, Jeffrey C, Newcomb, Dawn C

“…Females have an increased prevalence of many Th17 cell-mediated diseases, including asthma. Androgen signaling decreases Th17 cell-mediated airway…”
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Sex Differences in Inflammatory Responses to Adipose Tissue Lipolysis in Diet-Induced Obesity by Varghese, Mita, Griffin, Cameron, McKernan, Kaitlin, Eter, Leila, Lanzetta, Nicholas, Agarwal, Devyani, Abrishami, Simin, Singer, Kanakadurga

“…Abstract Males are known to have profound adipose tissue macrophage (ATM) accumulation in gonadal white adipose tissue (GWAT) during obesity, whereas females…”
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TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c+ adipose tissue macrophage production in obese mice by Griffin, Cameron, Eter, Leila, Lanzetta, Nico, Abrishami, Simin, Varghese, Mita, McKernan, Kaitlin, Muir, Lindsey, Lane, Jamie, Lumeng, Carey N., Singer, Kanakadurga

“…Obesity-induced chronic inflammation is associated with metabolic disease. Results from mouse models utilizing a high-fat diet (HFD) have indicated that an…”
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MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner by Xie, Guojia, Lee, Ji-Eun, Senft, Anna D., Park, Young-Kwon, Jang, Younghoon, Chakraborty, Shreeta, Thompson, Joyce J., McKernan, Kaitlin, Liu, Chengyu, Macfarlan, Todd S., Rocha, Pedro P., Peng, Weiqun, Ge, Kai

“…H3K4me1 methyltransferases MLL3 (KMT2C) and MLL4 (KMT2D) are critical for enhancer activation, cell differentiation and development. However, roles of MLL3/4…”
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SUN-105 Females Have Reduced Meta-Inflammation in Two States of Increased Adiposity, Obesity, and Aging by Varghese, Mita, Griffin, Cameron, McKernan, Kaitlin, Hayes, Taryn, Abrishami, Simin, Singer, Kanakadurga

“…Obesity is a global health epidemic, closely associated with cardiovascular diseases (CVD), hypertension, type 2 diabetes, and atherosclerosis. Obese adipose…”
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