Search Results - "McKeown, L P"

Caregivers of people with multiple sclerosis: experiences of support by McKeown, L P, Porter-Armstrong, A P, Baxter, G D

“…The aim of this pheno menological study was to gain an understanding of the experiences of a group of caregivers of people with multiple sclerosis (MS)…”
Get full text

The needs and experiences of caregivers of individuals with multiple sclerosis: a systematic review by McKeown, L P, Porter-Armstrong, A P, Baxter, G D

“…Primary objective: To appraise recent studies regarding the needs and experiences of caregivers of individuals with multiple sclerosis (MS). Design: The…”
Get full text

Activated platelets in paroxysmal nocturnal haemoglobinuria by Gralnick, H R, Vail, M, McKeown, L P, Merryman, P, Wilson, O, Chu, I, Kimball, J

“…One of the major causes of morbidity and mortality in paroxysmal nocturnal haemoglobinuria (PNH) is venous thrombosis. We have studied fibrinolysis,…”
Get more information

1‐desamino‐8‐arginine‐vasopressin corrects the hemostatic defects in type 2B von Willebrand's disease by McKeown, L.P., Connaghan, G., Wilson, O., Hansmann, K., Merryman, P., Gralnick, H.R.

“…DDAVP is effective treatment in most types of von Willebrand's disease; however, in type 2B von Willebrand's disease the use of DDAVP has been contraindicated…”
Get full text

Thrombocytopenia Associated With Pregnancy in a Patient With Type IIB von Willebrand’s Disease by Rick, Margaret E., Williams, Sybil B., Sacher, Ronald A., McKeown, Laurie P.

“…Thrombocytopenia may accompany variant (type IIB) von Willebrand's disease (vWD) and is thought to result from binding of the abnormal von Willebrand factor…”
Get full text

Purification and characterization of human platelet von Willebrand factor by Williams, S B, McKeown, L P, Krutzsch, H, Hansmann, K, Gralnick, H R

“…Platelet von Willebrand factor (vWf) was purified from human platelet concentrates. The multimeric structure of the purified platelet vWf was similar to that…”
Get more information

In vitro Correction of the Abnormal Multimeric Structure of Von Willebrand Factor in Type IIa Von Willebrand's Disease by Gralnick, Harvey R., Williams, Sybil B., McKeown, Laurie P., Maisonneuve, Pascal, Jenneau, Christine, Sultan, Yvette, Rick, Margaret E.

“…Type IIa von Willebrand's disease (vWd) has been characterized by the absence of the largest and a reduction in the intermediate-sized multimers of the plasma…”
Get full text

von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factor by GRALNICK, H. R, WILLIAMS, S. B, MCKEOWN, L. P, RICK, M. E, MAISONNEUVE, P, JENNEAU, C, SULTAN, Y

“…We have investigated and characterized the abnormalities in four unrelated patients with von Willebrand's disease (vWd) who have (a) enhanced…”
Get full text

Structure-Function Studies on the Inhibition of Binding of α-Thrombin to Platelet GpIbα by the Peptide D-Y-Y-P-E and the Artifactual Inhibitory Activity of C-Terminal E in this Peptide by Krutzsch, Henry, Williams, Sybil B., McKeown, Laurie P., Gralnick, Harvey R.

Get full text

DDAVP in Type IIa von Willebrand’s Disease by Gralnick, Harvey R., Williams, Sybil B., McKeown, Laurie P., Rick, Margaret E., Maisonneuve, Pascal, Jenneau, Christine, Sultan, Yvette

“…1-D-Amino(8-D-arginine)-vasopressin (DDAVP) infusion in three patients with type IIa von Willebrand’s disease (vWD) resulted in a normalization of the factor…”
Get full text

GLYCOCALICIN DERIVED PEPTIDES INHIBIT von WILLEBRAND FACTOR BINDING TO PLATELETS by Williams, Sybil B, Krutzsch, Henry, McKeown, Laurie P, Gralnick, Harvey R

Get full text

High-Affinity α-Thrombin Binding to Platelet Glycoprotein Ibα: Identification of Two Binding Domains by Gralnick, Harvey R., Williams, Sybil, McKeown, Laurie P., Hansmann, Kristin, Fenton, John W., Krutzsch, Henry

“…α-Thrombin binding to and activation of platelets are of major importance in the initiation of physiologic thrombi and in the genesis of arterial thrombus…”
Get full text

Platelet aggregation induced by type IIb platelet von Willebrand factor by Gralnick, H R, McKeown, L P, Williams, S, Jenneau, C, Sultan, Y, van Mourik, J

“…Platelet lysates from five patients with a form of type IIb von Willebrand's disease (vWd), associated with spontaneous platelet aggregation and…”
Get more information

Platelet von Willebrand factor in Hermansky‐Pudlak syndrome by McKeown, Laurie P., Hansmann, Kristin E., Wilson, Olga, Gahl, William, Gralnick, Harvey R., Rosenfeld, Kathryn E., Rosenfeld, Stephen J., Horne, McDonald K., Rick, Margaret E.

“…The Hermansky‐Pudlak Syndrome (HPS) is an autosomal recessive inherited disorder characterized by oculocutaneous albinism, tissue accumulation of ceroid…”
Get full text

Platelet von Willebrand Factor: An Important Determinant of the Bleeding Time in Type I von Willebrand’s Disease by Gralnick, Harvey R., Rick, Margaret E., McKeown, Laurie P., Williams, Sybil B., Parker, Robert I., Maisonneuve, Pascal, Jenneau, Christine, Sultan, Yvette

“…We studied 17 patients with moderate to mild type I von Willebrand's disease (vWd) and correlated the bleeding time with the plasma von Willebrand factor…”
Get full text

Platelet von Willebrand factor by Gralnick, H R, Williams, S B, McKeown, L P, Magruder, L, Hansmann, K, Vail, M, Parker, R I

“…von Willebrand factor (vWF) circulates in the blood in two distinct compartments. One, plasma vWF, is synthesized and released from endothelial cells; the…”
Get more information

Absence of the largest platelet-von Willebrand multimers in a patient with lactoferrin deficiency and a bleeding tendency by Parker, R I, McKeown, L P, Gallin, J I, Gralnick, H R

“…We have studied a young male with lactoferrin deficiency and a bleeding tendency responsive to cryoprecipitate. This child has had increased bleeding following…”
Get more information

Arginine-glycine-aspartic acid- and fibrinogen γ-chain carboxyterminal peptides inhibit platelet adherence to arterial subendothelium at high wall shear rates : an effect dissociable from interference with adhesive protein binding by LAWRENCE, J. B, KRAMER, W. S, MCKEOWN, L. P, WILLIAMS, S. B, GRALNICK, H. R

“…Arg-Gly-Asp (RGD)- and fibrinogen gamma-chain carboxyterminal (GQQHHLGGAKQAGDV) peptides inhibit fibrinogen, fibronectin (Fn), vitronectin, and von Willebrand…”
Get full text

Glycoprotein Ibα peptides inhibit thrombin and SFLLRN-induced platelet aggregation by MQCKEOWN, L. P, WILLIAMS, S. B, HANSMANN, K. E, KRUTZSCH, H, GRALINICK, H. R

“…The platelet glycoprotein Ib(alpha) (GPIb(alpha)) receptor contains a high-affinity binding site for thrombin that, when occupied, augments platelet activation…”
Get full text

A human chimera for von Willebrand disease following bone marrow transplantation by Ware, R E, Parker, R I, McKeown, L P, Graham, M L

“…von Willebrand disease (vWD) is a common bleeding disorder characterized by quantitative or qualitative defects in von Willebrand factor (vWF), a protein…”
Get more information