Search Results - "McKeown, Arlene"

Isolation and Structure Elucidation of Parnafungins, Antifungal Natural Products that Inhibit mRNA Polyadenylation by Parish, Craig A, Smith, Scott K, Calati, Kathleen, Zink, Deborah, Wilson, Kenneth, Roemer, Terry, Jiang, Bo, Xu, Deming, Bills, Gerald, Platas, Gonzalo, Peláez, Fernando, Díez, Maria Teresa, Tsou, Nancy, McKeown, Arlene E, Ball, Richard G, Powles, Mary Ann, Yeung, Lai, Liberator, Paul, Harris, Guy

“…The Candida albicans Fitness Test, a whole-cell screening platform, was used to profile crude fermentation extracts for novel antifungal natural products with…”
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Stereoselective Formation of Carbon−Carbon Bonds via SN2-Displacement:  Synthesis of Substituted Cycloalkyl[b]indoles by Hillier, Michael C, Marcoux, Jean-François, Zhao, Dalian, Grabowski, Edward J. J, McKeown, Arlene E, Tillyer, Richard D

“…A general asymmetric synthesis of substituted cycloalkyl[b]indoles has been accomplished. The key features of this approach are (1) the utilization of a…”
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Rapid conversion of API hydrates to anhydrous forms in aqueous media by Petrova, Rositza I, Peresypkin, Andrey, Mortko, Christopher J, McKeown, Arlene E, Lee, Jaemoon, Williams, J Michael

“…Three anhydrous polymorphs, a monohydrate and a dihydrate of an active pharmaceutical ingredient,…”
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On the Mechanism of an Asymmetric α,β-Unsaturated Carboxylic Acid Hydrogenation:  Application to the Synthesis of a PGD2 Receptor Antagonist by Tellers, David M, McWilliams, J. Christopher, Humphrey, Guy, Journet, Michel, DiMichele, Lisa, Hinksmon, Joseph, McKeown, Arlene E, Rosner, Thorsten, Sun, Yongkui, Tillyer, Richard D

“…Ruthenium complexes employing axially chiral ligands were found to be effective asymmetric hydrogenation catalysts for the reduction of α,β-unsaturated ene…”
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Basicity of Some Phosphines in THF by Streitwieser, Andrew, McKeown, Arlene E, Hasanayn, Faraj, Davis, Nicole R

“…The reaction of several phosphines with an acidic indicator gives both ion pairs and free ions. The value obtained for the pK a of tribenzylphosphine is shown…”
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Asymmetric Diels−Alder Reactions of Chiral Cyclopropylidene Imide Dienophiles:  Preparation of gem-Dimethyl- and Spirocyclopropane Norbornyl Carboxylic Acids by Kuethe, Jeffrey T, Zhao, Dalian, Humphrey, Guy R, Journet, Michel, McKeown, Arlene E

“…A highly efficient strategy has been developed for the rapid asymmetric synthesis of gem-dimethyl and spirocyclopropyl norbornyl carboxylic acids. The key…”
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Development of a Scaleable Synthesis of a Partial Nicotinic Acid Receptor Agonist by Wilson, Robert D, Cleator, Ed, Ashwood, Michael S, Bio, Matthew M, Brands, Karel M. J, Davies, Antony J, Dolling, Ulf-H, Emerson, Khateeta M, Gibb, Andrew D, Hands, David, McKeown, Arlene E, Oliver, Steven F, Reamer, Robert A, Sheen, Faye J, Stewart, Gavin W, Zhou, George X

“…A practical and efficient synthesis of 1,4,5,6-tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole, 1, is described. A new one-pot process has been developed,…”
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Formation of the Unprecedented Trilithio-Capped Heteroadamantanyl Iminoalane Anion [(HAl)4(NPh)6{Li(OEt2)}3]−: An Open Cage Derived from a Rhombododecahedron by Henderson, Kenneth W., Kennedy, Alan R., McKeown, Arlene E., Mulvey, Robert E.

“…An Al/N adamantanyl frame with three of its Al3N3 faces capped by Li (see picture; E=NPh) forms the core of the title anion. Formation of the charge‐separated…”
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Synthesis of zirconocene amides and ketimides and an investigation into their ethylene polymerization activity by Henderson, Kenneth W, Hind, Amanda, Kennedy, Alan R, McKeown, Arlene E, Mulvey, Robert E

“…The zirconocene amide [Cp 2Zr(Cl)N(CH 2Ph) 2] ( 5), and the zirconocene ketimides [Cp 2Zr(Cl)NC(Bu t )Ph] ( 7), and [Cp 2Zr(Cl)NC(NMe 2) 2] ( 9), have been…”
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Zirconocene Ketimides: Synthesis, Structural Characterization, Ethylene Polymerization Activity, and ab Initio Computational Studies by Armstrong, David R, Henderson, Kenneth W, Little, Ian, Jenny, Charles, Kennedy, Alan R, McKeown, Arlene E, Mulvey, Robert E

“…The metathetical reaction between the lithium 1-azaallyl compound [{HMPA·LiN(H)C(t-Bu)CH2}2] (1) with zirconocene dichloride (2) results in the formation of…”
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Development of a Multikilogram Scale Synthesis of a TRPV1 Antagonist by Kuethe, Jeffrey T, Journet, Michel, Peng, Zhihui, Zhao, Dalian, McKeown, Arlene, Humphrey, Guy R

“…A highly efficient, regioselective five-step synthesis of the TRPV1 antagonist 1 is described. The coupling of piperazine 7 with dichloropyrimidine 8 proceeded…”
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Dichlorobis(dibenzylamino)bis(tetrahydrofuran)zirconium(IV) toluene hemisolvate by HENDERSON, Kenneth W, KENNEDY, Alan R, MCKEOWN, Arlene E, MULVEY, Robert E

“…The title complex, [ZrCl2(C4H8O)2(C14H14N)2].0.5C7H8, was prepared in an unusual manner by utilizing [Mg[N(CH2Ph)2]2] as a ligand transfer reagent. The Zr atom…”
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On the Mechanism of an Asymmetric α,β-Unsaturated Carboxylic Acid Hydrogenation:  Application to the Synthesis of a PGD 2 Receptor Antagonist by Tellers, David M., McWilliams, J. Christopher, Humphrey, Guy, Journet, Michel, DiMichele, Lisa, Hinksmon, Joseph, McKeown, Arlene E., Rosner, Thorsten, Sun, Yongkui, Tillyer, Richard D.

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Stereoselective Formation of Carbon−Carbon Bonds via S N 2-Displacement:  Synthesis of Substituted Cycloalkyl[ b ]indoles by Hillier, Michael C., Marcoux, Jean-François, Zhao, Dalian, Grabowski, Edward J. J., McKeown, Arlene E., Tillyer, Richard D.

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Di­chloro­bis­(di­benzyl­amino)­bis­(tetra­hydro­furan)­zirconium(IV) toluene hemisolvate by Henderson, Kenneth W., Kennedy, Alan R., McKeown, Arlene E., Mulvey, Robert E.

“…The title complex, [ZrCl2(C4H8O)2(C14H14N)2]·0.5C7H8, was prepared in an unusual manner by utilizing [Mg{N(CH2Ph)2}2] as a ligand transfer reagent. The Zr atom…”
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Dimethylaluminium enolates and alkoxides derived from trimethylaluminium and aromatic ketones: a synthetic, structural and theoretical investigation by Allan, John F., Clegg, William, Elsegood, Mark R.J., Henderson, Kenneth W., McKeown, Arlene E., Moran, Paul H., Rakov, Igor M.

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Synthesis, characterisation and a theoretical investigation of the formation of lithium dialkylaluminium amides by Clegg, William, Liddle, Stephen T., Henderson, Kenneth W., Keenan, Fiona E., Kennedy, Alan R., McKeown, Arlene E., Mulvey, Robert E.

“…Reaction of the pre-formed crystalline amides [(PhCH 2) 2NLi] and [Me 2AlN(CH 2Ph) 2] in the presence of pyridine results in the formation of the mixed metal…”
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Formation of the Unprecedented Trilithio-Capped Heteroadamantanyl Iminoalane Anion [(HAl)4(NPh)6{Li(OEt2)}3]−: An Open Cage Derived from a Rhombododecahedron by Henderson, Kenneth W., Kennedy, Alan R., McKeown, Arlene E., Mulvey, Robert E.

“…Ein Al/N‐Adamantan‐Gerüst, bei dem drei der Al3N3‐Flächen durch Li überdacht sind (siehe Bild; E=NPh), bildet den Kern des Iminoalan‐Anions…”
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