Search Results - "McKeon, B"

CEO Personal Risk-Taking and Corporate Policies by Cain, Matthew D., McKeon, Stephen B.

“…This study analyzes the relation between chief executive officer (CEO) personal risk-taking, corporate risk-taking, and total firm risk. We find evidence that…”
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Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis by Zhang, Hui, Wang, Daren, Li, Min, Plecitá-Hlavatá, Lydie, D'Alessandro, Angelo, Tauber, Jan, Riddle, Suzette, Kumar, Sushil, Flockton, Amanda, McKeon, B Alexandre, Frid, Maria G, Reisz, Julie A, Caruso, Paola, El Kasmi, Karim C, Ježek, Petr, Morrell, Nicholas W, Hu, Cheng-Jun, Stenmark, Kurt R

“…An emerging metabolic theory of pulmonary hypertension (PH) suggests that cellular and mitochondrial metabolic dysfunction underlies the pathology of this…”
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Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension by Frid, Maria G, McKeon, B Alexandre, Thurman, Joshua M, Maron, Bradley A, Li, Min, Zhang, Hui, Kumar, Sushil, Sullivan, Timothy, Laskowsky, Jennifer, Fini, Mehdi A, Hu, Samantha, Tuder, Rubin M, Gandjeva, Aneta, Wilkins, Martin R, Rhodes, Christopher J, Ghataorhe, Pavandeep, Leopold, Jane A, Wang, Rui-Sheng, Holers, V Michael, Stenmark, Kurt R

“…Pulmonary hypertension (PH) is a life-threatening cardiopulmonary disorder in which inflammation and immunity have emerged as critical early pathogenic…”
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Debt Financing and Financial Flexibility Evidence from Proactive Leverage Increases by Denis, David J., McKeon, Stephen B.

“…Firms that intentionally increase leverage through substantial debt issuances do so primarily as a response to operating needs rather than a desire to make a…”
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Phase relationships between large and small scales in the turbulent boundary layer by Jacobi, I., McKeon, B. J.

“…The apparent amplitude modulation effect between large- and small-scale motions in the turbulent boundary layer, including both streamwise and wall-normal…”
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MicroRNA-124 Controls the Proliferative, Migratory, and Inflammatory Phenotype of Pulmonary Vascular Fibroblasts by Wang, Daren, Zhang, Hui, Li, Min, Frid, Maria G, Flockton, Amanda R, McKeon, B Alexandre, Yeager, Michael E, Fini, Mehdi A, Morrell, Nicholas W, Pullamsetti, Soni S, Velegala, Sivareddy, Seeger, Werner, McKinsey, Timothy A, Sucharov, Carmen C, Stenmark, Kurt R

“…RATIONALE:Pulmonary hypertensive remodeling is characterized by excessive proliferation, migration, and proinflammatory activation of adventitial fibroblasts…”
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Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1 by Li, Min, Riddle, Suzette, Zhang, Hui, D’Alessandro, Angelo, Flockton, Amanda, Serkova, Natalie J, Hansen, Kirk C, Moldvan, Radu, McKeon, B Alexandre, Frid, Maria, Kumar, Sushil, Li, Hong, Liu, Hongbing, Caánovas, Angela, Medrano, Juan F, Thomas, Milton G, Iloska, Dijana, Plecitá-Hlavatá, Lydie, Ježek, Petr, Pullamsetti, Soni, Fini, Mehdi A, El Kasmi, Karim C, Zhang, QingHong, Stenmark, Kurt R

“…BACKGROUND:Changes in metabolism have been suggested to contribute to the aberrant phenotype of vascular wall cells, including fibroblasts, in pulmonary…”
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Scaling and interaction of self-similar modes in models of high Reynolds number wall turbulence by Sharma, A. S., Moarref, R., McKeon, B. J.

“…Previous work has established the usefulness of the resolvent operator that maps the terms nonlinear in the turbulent fluctuations to the fluctuations…”
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TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension by Kumar, Rahul, Mickael, Claudia, Kassa, Biruk, Gebreab, Liya, Robinson, Jeffrey C., Koyanagi, Daniel E., Sanders, Linda, Barthel, Lea, Meadows, Christina, Fox, Daniel, Irwin, David, Li, Min, McKeon, B. Alexandre, Riddle, Suzette, Dale Brown, R., Morgan, Leslie E., Evans, Christopher M., Hernandez-Saavedra, Daniel, Bandeira, Angela, Maloney, James P., Bull, Todd M., Janssen, William J., Stenmark, Kurt R., Tuder, Rubin M., Graham, Brian B.

“…Pulmonary arterial hypertension (PAH) is an obstructive disease of the precapillary pulmonary arteries. Schistosomiasis-associated PAH shares altered vascular…”
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SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension by Li, Min, Plecitá-Hlavatá, Lydie, Dobrinskikh, Evgenia, McKeon, B Alexandre, Gandjeva, Aneta, Riddle, Suzette, Laux, Aya, Prasad, Ram Raj, Kumar, Sushil, Tuder, Rubin M, Zhang, Hui, Hu, Cheng-Jun, Stenmark, Kurt R

“…Pulmonary hypertension (PH) is a heterogeneous and life-threatening cardiopulmonary disorder in which mitochondrial dysfunction is believed to drive…”
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Local Complement Contributes to Pathogenic Activation of Lung Endothelial Cells in SARS-CoV-2 Infection by Zhang, Hui, Gerasimovskaya, Evgenia, McCarthy, Mary K, May, Nicholas A, Prasad, Ram Raj, Riddle, Suzette, McKeon, B Alexandre, Kumar, Sushil, Li, Min, Hu, Cheng-Jun, Frid, Maria G, Morrison, Thomas E, Stenmark, Kurt R

“…Endothelial dysfunction and inflammation contribute to the vascular pathology of coronavirus disease (COVID-19). However, emerging evidence does not support…”
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Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension by Anwar, Adil, Li, Min, Frid, Maria G, Kumar, Binod, Gerasimovskaya, Evgenia V, Riddle, Suzette R, McKeon, B Alexandre, Thukaram, Roopa, Meyrick, Barbara O, Fini, Mehdi A, Stenmark, Kurt R

“…Increased cell proliferation and migration, of several cell types are key components of vascular remodeling observed in pulmonary hypertension (PH). Our…”
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Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension by Li, Min, Riddle, Suzette R, Frid, Maria G, El Kasmi, Karim C, McKinsey, Timothy A, Sokol, Ronald J, Strassheim, Derek, Meyrick, Barbara, Yeager, Michael E, Flockton, Amanda R, McKeon, B Alexandre, Lemon, Douglas D, Horn, Todd R, Anwar, Adil, Barajas, Carlos, Stenmark, Kurt R

“…Persistent accumulation of monocytes/macrophages in the pulmonary artery adventitial/perivascular areas of animals and humans with pulmonary hypertension has…”
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A study of the three-dimensional spectral energy distribution in a zero pressure gradient turbulent boundary layer by LeHew, J., Guala, M., McKeon, B. J.

“…Time-resolved particle image velocimetry (PIV) measurements performed in wall parallel planes at three wall normal locations, y +  = 34, 108, and 278, in a…”
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Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension by Li, Min, Riddle, Suzette, Kumar, Sushil, Poczobutt, Joanna, McKeon, B Alexandre, Frid, Maria G, Ostaff, Maureen, Reisz, Julie A, Nemkov, Travis, Fini, Mehdi A, Laux, Aya, Hu, Cheng-Jun, El Kasmi, Karim C, D'Alessandro, Angelo, Brown, R Dale, Zhang, Hui, Stenmark, Kurt R

“…The recruitment and subsequent polarization of inflammatory monocytes/macrophages in the perivascular regions of pulmonary arteries is a key feature of…”
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Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension by Kumar, Sushil, Mickael, Claudia, Kumar, Rahul, Prasad, Ram Raj, Campbell, Nzali V, Zhang, Hui, Li, Min, McKeon, B Alexandre, Allen, Thaddeus E, Graham, Brian B, Yu, Yen-Rei A, Stenmark, Kurt R

“…Hypoxia is a common pathological driver contributing to various forms of pulmonary vascular diseases leading to pulmonary hypertension (PH). Pulmonary…”
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Unsteady force measurements in sphere flow from subcritical to supercritical Reynolds numbers by Norman, A. K., McKeon, B. J.

“…The flow over a smooth sphere is examined in the Reynolds number range of 5.0 × 10 4  <  Re  < 5.0 × 10 5 via measurements of the fluctuating forces and…”
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On the design of optimal compliant walls for turbulence control by Luhar, M., Sharma, A. S., McKeon, B. J.

“…This paper employs the resolvent framework to consider the design of compliant walls for turbulent skin friction reduction. Specifically, the effects of simple…”
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Time-resolved measurements of coherent structures in the turbulent boundary layer by LeHew, J. A., Guala, M., McKeon, B. J.

“…Time-resolved particle image velocimetry was used to examine the structure and evolution of swirling coherent structure (SCS), one interpretation of which is a…”
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A Real-Time Wideband Subband LMS Algorithm for Full-Duplex Communications by Lorenz, Kevin S., Goodman, Joel, Mcbeth, Michelle, Mckeon, Matthew B., Parrett, David J.

“…In-band full-duplex (IBFD) communications has the potential to nearly double the spectrum efficiency of existing 5G communications. Digital signal processing…”
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