Search Results - "McKenzie, Craig I."

Induction of IgG2 and IgG4 B‐cell memory following sublingual immunotherapy for ryegrass pollen allergy by Heeringa, Jorn J., McKenzie, Craig I., Varese, Nirupama, Hew, Mark, Bakx, Amy T. C. M., Aui, Pei M., Rolland, Jennifer M., O’Hehir, Robyn E., Zelm, Menno C.

“…Background While treatment for atopic rhinitis is aimed mostly to relieve symptoms, only allergen‐specific immunotherapy (AIT) is targeted to modify the…”
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Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk by Lassen, Kara G., McKenzie, Craig I., Mari, Muriel, Murano, Tatsuro, Begun, Jakob, Baxt, Leigh A., Goel, Gautam, Villablanca, Eduardo J., Kuo, Szu-Yu, Huang, Hailiang, Macia, Laurence, Bhan, Atul K., Batten, Marcel, Daly, Mark J., Reggiori, Fulvio, Mackay, Charles R., Xavier, Ramnik J.

“…Although numerous polymorphisms have been associated with inflammatory bowel disease (IBD), identifying the function of these genetic factors has proved…”
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Recent developments and highlights in immune monitoring of allergen immunotherapy by Zelm, Menno C., McKenzie, Craig I., Varese, Nirupama, Rolland, Jennifer M., O'Hehir, Robyn E.

“…Allergic diseases are the most common chronic immune‐mediated disorders and can manifest with an enormous diversity in clinical severity and symptoms…”
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The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21 by Zotos, Dimitra, Quast, Isaak, Li-Wai-Suen, Connie S. N., McKenzie, Craig I., Robinson, Marcus J., Kan, Andrey, Smyth, Gordon K., Hodgkin, Philip D., Tarlinton, David M.

“…Humoral immune responses require germinal centres (GC) for antibody affinity maturation. Within GC, B cell proliferation and mutation are segregated from…”
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Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites by Thorburn, Alison N., McKenzie, Craig I., Shen, Sj, Stanley, Dragana, Macia, Laurence, Mason, Linda J., Roberts, Laura K., Wong, Connie H. Y., Shim, Raymond, Robert, Remy, Chevalier, Nina, Tan, Jian K., Mariño, Eliana, Moore, Rob J., Wong, Lee, McConville, Malcolm J., Tull, Dedreia L., Wood, Lisa G., Murphy, Vanessa E., Mattes, Joerg, Gibson, Peter G., Mackay, Charles R.

“…Asthma is prevalent in Western countries, and recent explanations have evoked the actions of the gut microbiota. Here we show that feeding mice a high-fibre…”
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Interleukin-21, acting beyond the immunological synapse, independently controls T follicular helper and germinal center B cells by Quast, Isaak, Dvorscek, Alexandra R., Pattaroni, Celine, Steiner, Thiago M., McKenzie, Craig I., Pitt, Catherine, O’Donnell, Kristy, Ding, Zhoujie, Hill, Danika L., Brink, Robert, Robinson, Marcus J., Zotos, Dimitra, Tarlinton, David M.

“…Germinal centers (GCs), transient structures within B cell follicles and central to affinity maturation, require the coordinated behavior of T and B cells…”
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A recent patent in allergy & immunology: Biomarkers on allergen‐specific memory B cells to predict allergen immunotherapy outcome by Zelm, Menno C., O'Hehir, Robyn E., McKenzie, Craig I.

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IL‐21 has a critical role in establishing germinal centers by amplifying early B cell proliferation by Dvorscek, Alexandra R, McKenzie, Craig I, Robinson, Marcus J, Ding, Zhoujie, Pitt, Catherine, O'Donnell, Kristy, Zotos, Dimitra, Brink, Robert, Tarlinton, David M, Quast, Isaak

“…The proliferation and differentiation of antigen‐specific B cells, including the generation of germinal centers (GC), are prerequisites for long‐lasting,…”
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RNA sequencing of single allergen‐specific memory B cells after grass pollen immunotherapy: Two unique cell fates and CD29 as a biomarker for treatment effect by McKenzie, Craig I., Varese, Nirupama, Aui, Pei Mun, Reinwald, Simone, Wines, Bruce D., Hogarth, P. Mark, Thien, Francis, Hew, Mark, Rolland, Jennifer M., O'Hehir, Robyn E., Zelm, Menno C.

“…Background Sublingual immunotherapy (SLIT) for grass pollen allergy can modify the natural history of allergic rhinitis and is associated with increased…”
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Expansion of phenotypically modified type 2 memory B cells after allergen immunotherapy by von Borstel, Anouk, Reinwald, Simone, Aui, Pei M, McKenzie, Craig I, Varese, Nirupama, Hogarth, P Mark, Hew, Mark, O'Hehir, Robyn E, van Zelm, Menno C

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GPR43 – A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases by McKenzie, Craig I, Mackay, Charles R, Macia, Laurence

“…Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for…”
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Advances in allergen‐specific immune cell measurements for improved detection of allergic sensitization and immunotherapy responses by van Zelm, Menno C., McKenzie, Craig I., Varese, Nirupama, Rolland, Jennifer M., O’Hehir, Robyn E.

“…Over the past two decades, precision medicine has advanced diagnostics and treatment of allergic diseases. Component‐resolved analysis of allergen…”
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Subcutaneous immunotherapy for bee venom allergy induces epitope spreading and immunophenotypic changes in allergen-specific memory B cells by McKenzie, Craig I., Reinwald, Simone, Averso, Brett, Spurrier, Brett, Satz, Andrew, von Borstel, Anouk, Masinovic, Sabina, Varese, Nirupama, Aui, Pei Mun, Wines, Bruce D., Hogarth, P. Mark, Hew, Mark, Rolland, Jennifer M., O’Hehir, Robyn E., van Zelm, Menno C.

“…[Display omitted] Allergen immunotherapy (AIT) is the only disease-modifying treatment for allergic disorders. We have recently discovered that…”
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Epidemic thunderstorm asthma susceptibility from sensitization to ryegrass (Lolium perenne) pollen and major allergen Lol p 5 by Hew, Mark, Lee, Joy, Varese, Nirupama, Aui, Pei M., McKenzie, Craig I., Wines, Bruce D., Aumann, Heather, Rolland, Jennifer M., Mark Hogarth, Phillip, Zelm, Menno C., O’Hehir, Robyn E.

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CytoBas: Precision component‐resolved diagnostics for allergy using flow cytometric staining of basophils with recombinant allergen tetramers by McKenzie, Craig I., Varese, Nirupama, Aui, Pei M., Wines, Bruce D., Hogarth, Philip Mark, Thien, Francis, Hew, Mark, Rolland, Jennifer M., O’Hehir, Robyn E., Zelm, Menno C.

“…Background Diagnostic tests for allergy rely on detecting allergen‐specific IgE. Component‐resolved diagnostics incorporate multiple defined allergen…”
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pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis by Xie, Liang, McKenzie, Craig I, Qu, Xinyan, Mu, Yan, Wang, Quanbo, Bing, Nan, Naidoo, Karmella, Alam, Md Jahangir, Yu, Di, Gong, Fang, Ang, Caroline, Robert, Remy, Marques, Francine Z, Furlotte, Nicholas, Hinds, David, Gasser, Olivier, Xavier, Ramnik J, Mackay, Charles R

“…pH sensing by GPR65 regulates various inflammatory conditions, but its role in skin remains unknown. In this study, we performed a phenome-wide association…”
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Impaired memory B‐cell development and antibody maturation with a skewing toward IgE in patients with STAT3 hyper‐IgE syndrome by Veen, Willem, Krätz, Carolin E., McKenzie, Craig I., Aui, Pei M., Neumann, Jens, Noesel, Carel J. M., Wirz, Oliver F., Hagl, Beate, Kröner, Carolin, Spielberger, Benedikt D., Akdis, Cezmi A., Zelm, Menno C., Akdis, Mübeccel, Renner, Ellen D.

“…Background Signal transducer and activator of transcription 3 hyper‐IgE syndrome (STAT3‐HIES) is caused by heterozygous mutations in the STAT3 gene and is…”
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Induction of IgG 2 and IgG 4 B-cell memory following sublingual immunotherapy for ryegrass pollen allergy by Heeringa, Jorn J, McKenzie, Craig I, Varese, Nirupama, Hew, Mark, Bakx, Amy T C M, Aui, Pei M, Rolland, Jennifer M, O'Hehir, Robyn E, van Zelm, Menno C

“…While treatment for atopic rhinitis is aimed mostly to relieve symptoms, only allergen-specific immunotherapy (AIT) is targeted to modify the natural history…”
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An acetate‐yielding diet imprints an immune and anti‐microbial programme against enteric infection by Yap, Yu Anne, McLeod, Keiran H, McKenzie, Craig I, Gavin, Patrick G, Davalos‐Salas, Mercedes, Richards, James L, Moore, Robert J, Lockett, Trevor J, Clarke, Julie M, Eng, Vik Ven, Pearson, Jaclyn S, Hamilton‐Williams, Emma E, Mackay, Charles R, Mariño, Eliana

“…Objectives During gastrointestinal infection, dysbiosis can result in decreased production of microbially derived short‐chain fatty acids (SCFAs). In response…”
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Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges by Chevalier, Nina, Tan, Jian K, Mason, Linda J, Robert, Remy, McKenzie, Craig I, Lim, Florence, Wong, Connie H, Macia, Laurence, Thorburn, Alison N, Russ, Brendan E, Masters, Seth L, Mackay, Charles R

“…Abstract Environmental factors contribute to development of autoimmune diseases. For instance, human autoimmune arthritis can associate with intestinal…”
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