Down syndrome with low hypodiploidy in precursor B-cell acute lymphoblastic leukemia

We describe the rare finding of a 33-month-old child neonatally diagnosed with Down syndrome, who presented with pre-B acute lymphoblastic leukemia (ALL) with a pretreatment bone marrow karyotype in which a low hypodiploid cell line (38 chromosomes) was identified in 17/19 cells studied. The abnorma...

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Bibliographic Details
Published in:	Cancer genetics and cytogenetics Vol. 169; no. 1; pp. 58 - 61
Main Authors:	Morrissette, Jennifer J.D., Halligan, Gregory E., Punnett, Hope H., McKenzie, Ann Shoemaker, Guerrero, Felicula, de Chadarévian, J.P.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-08-2006
Subjects:	Burkitt Lymphoma - complications Burkitt Lymphoma - genetics Child, Preschool Diploidy Down Syndrome - complications Down Syndrome - genetics Female Humans Karyotyping Male
Online Access:	Get full text
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Summary:	We describe the rare finding of a 33-month-old child neonatally diagnosed with Down syndrome, who presented with pre-B acute lymphoblastic leukemia (ALL) with a pretreatment bone marrow karyotype in which a low hypodiploid cell line (38 chromosomes) was identified in 17/19 cells studied. The abnormal cell line retained the extra constitutional chromosome 21. Hypodiploidy (loss of one or more chromosomes) is seen in approximately 5% of all childhood pre-B ALL cases and in approximately 2.2% cases of individuals with a constitutional trisomy 21. Low hypodiploidy, associated with a high risk of relapse, is rare in pediatric ALL cases in the general population, and, to our knowledge, is previously unreported in patients with trisomy 21.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0165-4608 1873-4456
DOI:	10.1016/j.cancergencyto.2006.02.007