Search Results - "McKenzie, Andrew N"

Innate lymphoid cells: A new paradigm in immunology by Eberl, Gérard, Colonna, Marco, Di Santo, James P., McKenzie, Andrew N. J.

“…Cells acting at the intersection of immunity For years, scientists divided the immune system into two arms: innate and adaptive. The cell types involved in the…”
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IL‐33 citrine reporter mice reveal the temporal and spatial expression of IL‐33 during allergic lung inflammation by Hardman, Clare S., Panova, Veera, McKenzie, Andrew N. J.

“…Interleukin‐33 (IL‐33) is an IL‐1 family cytokine that signals via its receptor T1/ST2, and is a key regulator of inflammation, notably the type‐2 response…”
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TH2 cell development and function by Walker, Jennifer A., McKenzie, Andrew N. J.

“…Key Points T helper 2 (T H 2) cells respond to a variety of environmental cues, either directly or indirectly through interaction with cells of the innate…”
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Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis by Mchedlidze, Tamar, Waldner, Maximilian, Zopf, Steffen, Walker, Jennifer, Rankin, Andrew L., Schuchmann, Marcus, Voehringer, David, McKenzie, Andrew N.J., Neurath, Markus F., Pflanz, Stefan, Wirtz, Stefan

“…Liver fibrosis is a consequence of chronic liver diseases and thus a major cause of mortality and morbidity. Clinical evidence and animal studies suggest that…”
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Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation by Halim, Timotheus Y.F., Steer, Catherine A., Mathä, Laura, Gold, Matthew J., Martinez-Gonzalez, Itziar, McNagny, Kelly M., McKenzie, Andrew N.J., Takei, Fumio

“…Naive CD4+ T cell differentiation into distinct subsets of T helper (Th) cells is a pivotal process in the initiation of the adaptive immune response…”
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Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway by Yu, Yong, Tsang, Jason C. H., Wang, Cui, Clare, Simon, Wang, Juexuan, Chen, Xi, Brandt, Cordelia, Kane, Leanne, Campos, Lia S., Lu, Liming, Belz, Gabrielle T., McKenzie, Andrew N. J., Teichmann, Sarah A., Dougan, Gordon, Liu, Pentao

“…Single-cell RNA sequencing of bone marrow innate lymphoid cell (ILC) precursors reveals that PD-1 marks a committed ILC progenitor and that ILC2 development…”
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MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion by Oliphant, Christopher J., Hwang, You Yi, Walker, Jennifer A., Salimi, Maryam, Wong, See Heng, Brewer, James M., Englezakis, Alexandros, Barlow, Jillian L., Hams, Emily, Scanlon, Seth T., Ogg, Graham S., Fallon, Padraic G., McKenzie, Andrew N.J.

“…Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and…”
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An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers by Morita, Hideaki, Arae, Ken, Unno, Hirotoshi, Miyauchi, Kousuke, Toyama, Sumika, Nambu, Aya, Oboki, Keisuke, Ohno, Tatsukuni, Motomura, Kenichiro, Matsuda, Akira, Yamaguchi, Sachiko, Narushima, Seiko, Kajiwara, Naoki, Iikura, Motoyasu, Suto, Hajime, McKenzie, Andrew N.J., Takahashi, Takao, Karasuyama, Hajime, Okumura, Ko, Azuma, Miyuki, Moro, Kazuyo, Akdis, Cezmi A., Galli, Stephen J., Koyasu, Shigeo, Kubo, Masato, Sudo, Katsuko, Saito, Hirohisa, Matsumoto, Kenji, Nakae, Susumu

“…House dust mite-derived proteases contribute to allergic disorders in part by disrupting epithelial barrier function. Interleukin-33 (IL-33), produced by lung…”
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Respiratory syncytial virus infection activates IL-13–producing group 2 innate lymphoid cells through thymic stromal lymphopoietin by Stier, Matthew T., BS, Bloodworth, Melissa H., BS, Toki, Shinji, PhD, Newcomb, Dawn C., PhD, Goleniewska, Kasia, MS, Boyd, Kelli L., DVM, PhD, Quitalig, Marc, Hotard, Anne L., PhD, Moore, Martin L., PhD, Hartert, Tina V., MD, MPH, Zhou, Baohua, PhD, McKenzie, Andrew N., PhD, Peebles, R. Stokes, MD

“…Background Respiratory syncytial virus (RSV) is a major health care burden with a particularly high worldwide morbidity and mortality rate among infants. Data…”
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IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis by Hams, Emily, Armstrong, Michelle E., Barlow, Jillian L., Saunders, Sean P., Schwartz, Christian, Cooke, Gordon, Fahy, Ruairi J., Crotty, Thomas B., Hirani, Nikhil, Flynn, Robin J., Voehringer, David, McKenzie, Andrew N. J., Donnelly, Seamas C., Fallon, Padraic G.

“…Disease conditions associated with pulmonary fibrosis are progressive and have a poor long-term prognosis with irreversible changes in airway architecture…”
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OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer by Damgaard, Rune Busk, Jolin, Helen E., Allison, Michael E. D., Davies, Susan E., Titheradge, Hannah L., McKenzie, Andrew N. J., Komander, David

“…Methionine-1 (M1)-linked polyubiquitin chains conjugated by the linear ubiquitin chain assembly complex (LUBAC) control NF-κB activation, immune homoeostasis,…”
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Innate Lymphoid Cells in Inflammation and Immunity by McKenzie, Andrew N.J., Spits, Hergen, Eberl, Gerard

“…Innate lymphoid cells (ILCs) were first described as playing important roles in the development of lymphoid tissues and more recently in the initiation of…”
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Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity by Barlow, Jillian L., PhD, Bellosi, Agustin, PhD, Hardman, Clare S., BSc, Drynan, Lesley F., MSc, Wong, See Heng, PhD, Cruickshank, James P, McKenzie, Andrew N.J., PhD

“…Background IL-4, IL-5, and IL-13 are thought to be central to the allergic asthmatic response. Previous work supposed that the essential source of these…”
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Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity by McKenzie, Andrew N. J, Neill, Daniel R, Wong, See Heng, Bellosi, Agustin, Flynn, Robin J, Daly, Maria, Langford, Theresa K. A, Bucks, Christine, Kane, Colleen M, Fallon, Padraic G, Pannell, Richard, Jolin, Helen E

“…Innate immunity provides the first line of defence against invading pathogens and provides important cues for the development of adaptive immunity. Type-2…”
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IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction by Barlow, Jillian L., PhD, Peel, Samantha, PhD, Fox, Jane, PhD, Panova, Veera, MRes, Hardman, Clare S., BSc, Camelo, Ana, PhD, Bucks, Christine, PhD, Wu, Xiaoying, MD, Kane, Colleen M., PhD, Neill, Daniel R., PhD, Flynn, Robin J., PhD, Sayers, Ian, PhD, Hall, Ian P., DM, McKenzie, Andrew N.J., PhD

“…Background IL-25 and IL-33 belong to distinct cytokine families, but experimental mouse studies suggest their immunologic functions in type 2 immunity are…”
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ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung by Schuijs, Martijn J., Png, Shaun, Richard, Arianne C., Tsyben, Anastasia, Hamm, Gregory, Stockis, Julie, Garcia, Celine, Pinaud, Silvain, Nicholls, Ashley, Ros, Xavier Romero, Su, Jing, Eldridge, Matthew D., Riedel, Angela, Serrao, Eva M., Rodewald, Hans-Reimer, Mack, Matthias, Shields, Jacqueline D., Cohen, E. Suzanne, McKenzie, Andrew N. J., Goodwin, Richard J. A., Brindle, Kevin M., Marioni, John C., Halim, Timotheus Y. F.

“…Metastasis constitutes the primary cause of cancer-related deaths, with the lung being a commonly affected organ. We found that activation of lung-resident…”
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Innate lymphoid cells — how did we miss them? by Walker, Jennifer A., Barlow, Jillian L., McKenzie, Andrew N. J.

“…Key Points Innate lymphoid cells (ILCs) are newly identified members of the lymphoid lineage with emerging roles in mediating immune responses and in…”
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Innate lymphoid cells — a proposal for uniform nomenclature by Spits, Hergen, Artis, David, Colonna, Marco, Diefenbach, Andreas, Di Santo, James P., Eberl, Gerard, Koyasu, Shigeo, Locksley, Richard M., McKenzie, Andrew N. J., Mebius, Reina E., Powrie, Fiona, Vivier, Eric

“…Innate lymphoid cells (ILCs) have key roles in immune responses, lymphoid tissue development and tissue regeneration. Recently, several new ILC subsets were…”
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The Interleukin-33-Group 2 Innate Lymphoid Cell Axis Represents a Potential Adjuvant Target To Increase the Cross-Protective Efficacy of Influenza Vaccine by Williams, Clare M, Roy, Sreeja, Califano, Danielle, McKenzie, Andrew N J, Metzger, Dennis W, Furuya, Yoichi

“…Interleukin-33 (IL-33) is a multifunctional cytokine that mediates type 2-dominated immune responses. In contrast, the role of IL-33 during viral vaccination,…”
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Group 2 Innate Lymphoid Cells Express Functional NKp30 Receptor Inducing Type 2 Cytokine Production by Salimi, Maryam, Xue, Luzheng, Jolin, Helen, Hardman, Clare, Cousins, David J, McKenzie, Andrew N J, Ogg, Graham S

“…Group 2 innate lymphoid cells (ILC2) are important in effector functions for eliciting allergic inflammation, parasite defense, epithelial repair, and lipid…”
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