Search Results - "McKenna, Sean D."

Avelumab internalization by human circulating immune cells is mediated by both Fc gamma receptor and PD-L1 binding by Jin, Hulin, D'Urso, Vittorio, Neuteboom, Berend, McKenna, Sean D., Schweickhardt, Rene, Gross, Alec W., Fomekong Nanfack, Yves, Paoletti, Andrea, Carter, Carina, Toleikis, Lars, Fluck, Markus, Scheuenpflug, Juergen, Cai, Ti

“…Avelumab is an IgG1 anti-programmed death ligand 1 (anti-PD-L1) monoclonal antibody that has been approved as a monotherapy for metastatic Merkel cell…”
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Anti-EGFR biparatopic-SEED antibody has enhanced combination-activity in a single molecule by Kelton, Christie, Wesolowski, John S., Soloviev, Maria, Schweickhardt, Rene, Fischer, David, Kurosawa, Emmi, McKenna, Sean D., Gross, Alec W.

“…► Combinations of anti-EGFR antibodies are reported to result in enhanced activity. ► Anti-EGFR biparatopic-SEED antibody was created with two different…”
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Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer by Jiang, Xuliang, Fischer, David, Chen, Xiaoyan, McKenna, Sean D., Liu, Heli, Sriraman, Venkataraman, Yu, Henry N., Goutopoulos, Andreas, Arkinstall, Steve, He, Xiaolin

“…Follicle-stimulating hormone receptor (FSHR), a G-protein coupled receptor, is an important drug target in the development of novel therapeutics for…”
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Tumor necrosis factor (TNF)-soluble high-affinity receptor complex as a TNF antagonist by McKenna, Sean D, Feger, Georg, Kelton, Christie, Yang, Meijia, Ardissone, Vittoria, Cirillo, Rocco, Vitte, Pierre-Alain, Jiang, Xuliang, Campbell, Robert K

“…A novel high-affinity inhibitor of tumor necrosis factor (TNF) is described, which is created by the fusion of the extracellular domains of TNF-binding protein…”
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Synthesis and evaluation of a γ-lactam as a highly selective EP2 and EP4 receptor agonist by YUFANG XIAO, LUCA ARALDI, Gian, ZHONG ZHAO, REDDY, Adulla, KARRA, Srinivasa, BRUGGER, Nadia, FISCHER, David, PALMER, Elizabeth, BAO, Bagna, MCKENNA, Sean D

“…Gamma-lactam analogs (2) of EP(4) receptor agonists were identified by substitution of the pyrazolidinone ring (1) with a pyrrolidinone ring. Several compounds…”
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Pharmacological Inhibition of Phosphodiesterase 4 Triggers Ovulation in Follicle-Stimulating Hormone-Primed Rats by McKenna, Sean D, Pietropaolo, Michael, Tos, Enrico Gillio, Clark, Ann, Fischer, David, Kagan, David, Bao, Bagna, Chedrese, P. Jorge, Palmer, Stephen

“…Phosphodiesterases (PDEs) are a family of enzymes that hydrolyze cyclic nucleotides to render them biologically inactive. As such, these enzymes are critical…”
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Formation of human IFN-beta complex with the soluble type I interferon receptor IFNAR-2 leads to enhanced IFN stability, pharmacokinetics, and antitumor activity in xenografted SCID mice by McKenna, Sean D, Vergilis, Kristin, Arulanandam, Antonio R N, Weiser, Weishui Y, Nabioullin, Roustem, Tepper, Mark A

“…Interferon-beta (IFN-beta) is biologically unstable under physiologic conditions in vitro and is cleared rapidly from the bloodstream on administration in…”
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Identification of an IL-7-Associated Pre-Pro-B Cell Growth-Stimulating Factor (PPBSF). I. Production of the Non-IL-7 Component by Bone Marrow Stromal Cells from IL-7 Gene-Deleted Mice by McKenna, Sean D, Chen, Fangqi, Lai, Laijun, Goldschneider, Irving

“…Mouse bone marrow (BM) stromal cell conditioned medium (CM) from our long-term lymphoid culture system selectively induces the in vitro proliferation and…”
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Synthesis and evaluation of a gamma -lactam as a highly selective EP sub(2) and EP sub(4) receptor agonist by Xiao, Yufang, Araldi, Gian Luca, Zhao, Zhong, Reddy, Adulla, Karra, Srinivasa, Brugger, Nadia, Fischer, David, Palmer, Elizabeth, Bao, Bagna, Mckenna, Sean D

“…gamma -Lactam analogs ( 2) of EP sub(4) receptor agonists were identified by substitution of the pyrazolidinone ring ( 1) with a pyrrolidinone ring. Several…”
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Synthesis and evaluation of a γ-lactam as a highly selective EP 2 and EP 4 receptor agonist by Xiao, Yufang, Araldi, Gian Luca, Zhao, Zhong, Reddy, Adulla, Karra, Srinivasa, Brugger, Nadia, Fischer, David, Palmer, Elizabeth, Bao, Bagna, Mckenna, Sean D.

“…γ-Lactam analogs ( 2) of EP 4 receptor agonists were identified by substitution of the pyrazolidinone ring ( 1) with a pyrrolidinone ring. Several compounds…”
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A Selective Culture System for Generating TerminalDeoxynucleotidyl Transferase‐Positive Lymphoid Cells In Vitro . V. Detection of Stage‐Specific Pro‐B‐CellStimulating Activity in Medium Conditioned by Mouse Bone Marrow Stromal Cells by Mckenna, Sean D., Goldschneider, Irving

“…The selective in vitro generation of rat, mouse, and human terminal deoxynucleotidyl transferase‐positive (TdT + lymphoid cells in our long‐term xenogeneic…”
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Public Health and Primary Care by Rick Mayes PhD, Sean McKenna MD

“…Why are the goals of public health and primary care less politically popular and financially supported than those of curative medicine? A major part of the…”
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A selective culture system for generating terminal deoxynucleotidyl transferase-positive lymphoid cells in vitro. V. Detection of stage-specific pro-B-cell stimulating activity in medium conditioned by mouse bone marrow stromal cells by McKenna, S D, Goldschneider, I

“…The selective in vitro generation of rat, mouse, and human terminal deoxynucleotidyl transferase-positive (TdT+) lymphoid cells in our long-term xenogeneic…”
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