Search Results - "McKelvy, Jeffrey"

Effect of scavenger receptor class B type I antagonist ITX5061 in patients with hepatitis C virus infection undergoing liver transplantation by Rowe, Ian A., Tully, Damien C., Armstrong, Matthew J., Parker, Richard, Guo, Kathy, Barton, Darren, Morse, Gene D., Venuto, Charles S., Ogilvie, Colin B., Hedegaard, Ditte L., McKelvy, Jeffrey F., Wong‐Staal, Flossie, Allen, Todd M., Balfe, Peter, McKeating, Jane A., Mutimer, David J.

“…Hepatitis C virus (HCV) entry inhibitors have been hypothesized to prevent infection of the liver after transplantation. ITX5061 is a scavenger receptor class…”
Get full text

Effect of scavenger receptor B-I antagonist, ITX5061, on early hepatitis C virus kinetics in liver transplantation: results of a phase 1b clinical trial by Rowe, Ian, Dr, Armstrong, Matthew, MBChB, Parker, Richard, MBChB, Guo, Kathy, RN, Barton, Darren, BSc, McKelvy, Jeffrey, PhD, Wong-Staal, Flossie, Prof, Adams, David, Prof, McKeating, Jane, Prof, Mutimer, David, Prof

“…Abstract Background Prevention of recurrent hepatitis C virus (HCV) infection after liver transplantation is a major unmet clinical need. ITX5061 is a small…”
Get full text

Targeting HCV entry for development of therapeutics by Wong-Staal, Flossie, Syder, Andrew J, McKelvy, Jeffrey F

“…Recent progress in defining the molecular mechanisms of Hepatitis C Virus (HCV) entry affords the opportunity to exploit new viral and host targets for…”
Get full text

Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors by Syder, Andrew J, Lee, Haekyung, Zeisel, Mirjam B, Grove, Joe, Soulier, Eric, Macdonald, James, Chow, Stephine, Chang, Julia, Baumert, Thomas F, McKeating, Jane A, McKelvy, Jeffrey, Wong-Staal, Flossie

“…Background and Aims ITX 5061 is a clinical stage small molecule compound that promotes high-density lipoprotein (HDL) levels in animals and patients by…”
Get full text

Evaluation of ITX 5061, a Scavenger Receptor B1 Antagonist: Resistance Selection and Activity in Combination With Other Hepatitis C Virus Antivirals by Zhu, Haihong, Wong-Staal, Flossie, Lee, Haekyung, Syder, Andrew, McKelvy, Jeffrey, Schooley, Robert T., Wyles, David L.

“…ITX 5061 is a scavenger receptor B1 antagonist that has entered phase 1 clinical trials in hepatitis C virus (HCV)-infected humans. We evaluated ITX 5061 in…”
Get full text

Discovery of highly potent small molecule Hepatitis C Virus entry inhibitors by Mittapalli, Gopi Kumar, Jackson, Andrew, Zhao, Fang, Lee, Haekyung, Chow, Stephine, McKelvy, Jeffrey, Wong-Staal, Flossie, Macdonald, James E.

“…Novel, highly potent small molecule HCV entry inhibitors are reported. The SAR exploration of a hit molecule identified from screening of a compound library…”
Get full text

Effect of scavenger receptor BI antagonist ITX5061 in patients with hepatitis C virus infection undergoing liver transplantation by Rowe, Ian A, Tully, Damien C, Armstrong, Matthew J, Parker, Richard, Guo, Kathy, Barton, Darren, Morse, Gene D, Venuto, Charles S, Ogilvie, Colin B, Hedegaard, Ditte L, McKelvy, Jeffrey F, Wong-Staal, Flossie, Allen, Todd M, Balfe, Peter, McKeating, Jane A, Mutimer, David J

“…Hepatitis C virus (HCV) entry inhibitors have been hypothesized to prevent infection of the liver after transplantation. ITX5061 is a Scavenger Receptor B-I…”
Get full text

Discovery of ITX 4520: A highly potent orally bioavailable hepatitis C virus entry inhibitor by Mittapalli, Gopi Kumar, Zhao, Fang, Jackson, Andrew, Gao, Hongfeng, Lee, Haekyung, Chow, Stephine, Kaur, Maninder Pal, Nguyen, Natalie, Zamboni, Robert, McKelvy, Jeffrey, Wong-Staal, Flossie, Macdonald, James E.

“…The manuscript reports an identification of a highly potent, orally bioavailable hepatitis C virus entry inhibitor through optimization of a previously…”
Get full text

Evaluation of ITX 5061, a Scavenger Receptor B1 Antagonist: Resistance Selection and Activity in Combination With Other Hepatitis Virus Antivirals by Zhu, Haihong, Wong-Staal, Flossie, Lee, Haekyung, Syder, Andrew, McKelvy, Jeffrey, Schooley, Robert T., Wyles, David L.

“…ITX 5061 is a scavenger receptor B1 antagonist that has entered phase 1 clinical trials in hepatitis C virus (HCV)-infected humans. We evaluated ITX 5061 in…”
Get full text

ITX 5061 quantitation in human plasma with reverse phase liquid chromatography and mass spectrometry detection by Hochreiter, Jill, Lapham, Jill, Wong-Staal, Flossie, McKelvy, Jeffrey, Sulkowski, Mark, Glesby, Marshall J, Johnson, Victoria A, Morse, Gene D

“…ITX 5061 is a highly potent small molecule inhibitor of scavenger receptor-B1, an integral transmembrane protein that is found in liver cells and is actively…”
Get more information

Advances in pain therapeutics by LoGrasso, Philip, McKelvy, Jeffrey

“…Recent work in defining molecular targets for neuropathic pain has been plentiful and varied. Three novel targets have received much attention recently:…”
Get full text

An aminopeptidase from bovine brain which catalyzes the hydrolysis of enkephalin by Hersh, L B, McKelvy, J F

“…An aminopeptidase from bovine brain which catalyzes the hydrolysis of the tyrosyl1-glycine2 bond of methionine5-enkephalin has been purified to electrophoretic…”
Get more information

Cleavage of endorphins to des-Tyr endorphins by homogeneous bovine brain aminopeptidase by Hersh, Louis B, Smith, Thomas E, McKelvy, Jeffrey F

Get full text

Immunoreactive thyrotrophin releasing factor in gastropod circumoesophageal ganglia by GRIMM-JØRGENSEN, YVONNE, MCKELVY, JEFFREY F, JACKSON, IVOR M. D

Get full text

Thyrotropin releasing hormone augments growth of spinal cord transplants in oculo by Henschen, A, Zerbe, G, Nadzan, A M, McKelvy, J F, Olson, L, Hoffer, B

“…The effects of thyrotropin releasing hormone (TRH) on spinal cord growth were evaluated using the in oculo transplant model. The growth of fetal spinal cord…”
Get more information

Specific and Irreversible Inhibition of Lysozyme by 2′,3′-Epoxypropyl β-Glycosides of N-Acetyl-D-glucosamine Oligomers by THOMAS, EMRYS W, MCKELVY, JEFFREY F, SHARON, NATHAN

Get full text

Identification of Aspartic Acid 52 as the Point of Attachment of an Affinity Label in Hen Egg White Lysozyme by Eshdat, Y, McKelvy, J F, Sharon, N

“…Hen egg white lysozyme, fully inactivated by the affinity-labeling reagent, the 2',3'-epoxypropyl β-glycoside of di-( N -acetyl- d -glucosamine), contained 1…”
Get full text

Chemical Neurobiology. An Introduction to Neurochemistry. H. F. Bradford by McKelvy, Jeffrey F.

Get full text

Two forms of the rat D2 dopamine receptor as revealed by the polymerase chain reaction by Rao, Donald D., McKelvy, Jeffrey, Kebabian, John, MacKenzie, Robert G.

“…We have used the polymerase chain reaction technique (PCR) to clone the cDNA of the D2 dopamine receptor from rat striatal mRNA. Two major PCR products were…”
Get full text

Glycine transport inhibitors: A new class of antipsychotics? by Borden, Laurence A., Bell, Stanley C., Ognyanov, Vassil I., Albert, Vivian R., Zhang, Jing, De Vivo, Michael, Yokoyama, Midori, Xie, Xiaping, Berger, Theodore, Gerhardt, Greg, McKelvy, Jeffrey F.

Get full text