Search Results - "McKelvey, C."

Neutrophil-Derived Proteases in Lung Inflammation: Old Players and New Prospects by Cheetham, Coby J, McKelvey, Michael C, McAuley, Daniel F, Taggart, Clifford C

“…Neutrophil-derived proteases are critical to the pathology of many inflammatory lung diseases, both chronic and acute. These abundant enzymes play roles in key…”
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Development of amorphous solid dispersion formulations of a poorly water-soluble drug, MK-0364 by Sotthivirat, S., McKelvey, C., Moser, J., Rege, B., Xu, W., Zhang, D.

“…The goal of this study was to demonstrate that MK-0364 solid dispersions can be developed as a means to increase the solubility and bioavailability of a poorly…”
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Airway Inflammation and Host Responses in the Era of CFTR Modulators by Keown, Karen, Brown, Ryan, Doherty, Declan F, Houston, Claire, McKelvey, Michael C, Creane, Shannice, Linden, Dermot, McAuley, Daniel F, Kidney, Joseph C, Weldon, Sinéad, Downey, Damian G, Taggart, Clifford C

“…The arrival of cystic fibrosis transmembrane conductance regulator (CFTR) modulators as a new class of treatment for cystic fibrosis (CF) in 2012 represented a…”
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Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity by Bednash, Joseph S., Weathington, Nathaniel, Londino, James, Rojas, Mauricio, Gulick, Dexter L., Fort, Robert, Han, SeungHye, McKelvey, Alison C., Chen, Bill B., Mallampalli, Rama K.

“…Inflammasomes regulate innate immune responses by facilitating maturation of inflammatory cytokines, interleukin (IL)-1β and IL-18. NACHT, LRR and PYD…”
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Proteases, Mucus, and Mucosal Immunity in Chronic Lung Disease by McKelvey, Michael C, Brown, Ryan, Ryan, Sinéad, Mall, Marcus A, Weldon, Sinéad, Taggart, Clifford C

“…Dysregulated protease activity has long been implicated in the pathogenesis of chronic lung diseases and especially in conditions that display mucus…”
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Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4 by Lear, Travis, McKelvey, Alison C, Rajbhandari, Shristi, Dunn, Sarah R, Coon, Tiffany A, Connelly, William, Zhao, Joe Y, Kass, Daniel J, Zhang, Yingze, Liu, Yuan, Chen, Bill B

“…The E3 small ubiquitin-like modifier (SUMO) protein ligase protein inhibitor of activated STAT 4 (PIAS4) is a pivotal protein in regulating the TGFβ pathway…”
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The proinflammatory role of HECTD2 in innate immunity and experimental lung injury by Coon, Tiffany A, McKelvey, Alison C, Lear, Travis, Rajbhandari, Shristi, Dunn, Sarah R, Connelly, William, Zhao, Joe Y, Han, SeungHye, Liu, Yuan, Weathington, Nathaniel M, McVerry, Bryan J, Zhang, Yingze, Chen, Bill B

“…Invading pathogens may trigger overactivation of the innate immune system, which results in the release of large amounts of proinflammatory cytokines (cytokine…”
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E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia by Chen, Bill B., Coon, Tiffany A., Glasser, Jennifer R., Zou, Chunbin, Ellis, Bryon, Das, Tuhin, McKelvey, Alison C., Rajbhandari, Shristi, Lear, Travis, Kamga, Christelle, Shiva, Sruti, Li, Chenjian, Pilewski, Joseph M., Callio, Jason, Chu, Charleen T., Ray, Anuradha, Ray, Prabir, Tyurina, Yulia Y., Kagan, Valerian E., Mallampalli, Rama K.

“…Acute lung injury (ALI) is linked to mitochondrial injury, resulting in impaired cellular oxygen utilization; however, it is unknown how these events are…”
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The Impact of Aging in Acute Respiratory Distress Syndrome: A Clinical and Mechanistic Overview by Brown, Ryan, McKelvey, Michael C, Ryan, Sinéad, Creane, Shannice, Linden, Dermot, Kidney, Joseph C, McAuley, Daniel F, Taggart, Clifford C, Weldon, Sinéad

“…Acute respiratory distress syndrome (ARDS) is associated with increased morbidity and mortality in the elderly population (≥65 years of age). Additionally, age…”
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Novel PDE4 inhibitors derived from Chinese medicine forsythia by Coon, Tiffany A, McKelvey, Alison C, Weathington, Nate M, Birru, Rahel L, Lear, Travis, Leikauf, George D, Chen, Bill B

“…Cyclic adenosine monophosphate (cAMP) is a crucial intracellular second messenger molecule that converts extracellular molecules to intracellular signal…”
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RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity by McKelvey, Alison C, Lear, Travis B, Dunn, Sarah R, Evankovich, John, Londino, James D, Bednash, Joseph S, Zhang, Yingze, McVerry, Bryan J, Liu, Yuan, Chen, Bill B

“…Toll-like receptor 2 (TLR2) is a pattern recognition receptor that recognizes many types of PAMPs that originate from gram-positive bacteria. Here we describe…”
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Last among equals: perceptions and prospects of further education trained PGCE holders in the age of 'parity' by Best, M., Ade-Ojo, G. O., McKelvey, C.

“…This study explores how Further Education (FE) lecturers are perceived in secondary school settings and their professional prospects in the context of the UK…”
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Templating Hollow Polymeric Spheres from Catanionic Equilibrium Vesicles:  Synthesis and Characterization by McKelvey, C. A, Kaler, E. W, Zasadzinski, J. A, Coldren, B, Jung, H.-T

“…Hollow polymer spheres of styrene and divinyl benzene can be templated from catanionic equilibrium vesicles formed by cetyltrimethylammonium tosylate (CTAT)…”
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Targeting Proteases in Cystic Fibrosis Lung Disease. Paradigms, Progress, and Potential by McKelvey, Michael C, Weldon, Sinéad, McAuley, Daniel F, Mall, Marcus A, Taggart, Clifford C

“…Weldon et al discuss the cystic fibrosis (CF) which is an autosomal recessive genetic condition, predominantly of white populations, that impacts multiple…”
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Expanding the role of clinical pharmacists on interdisciplinary primary care teams for chronic pain and opioid management by Giannitrapani, Karleen F, Glassman, Peter A, Vang, Derek, McKelvey, Jeremiah C, Thomas Day, R, Dobscha, Steven K, Lorenz, Karl A

“…Facilitating appropriate and safe prescribing of opioid medications for chronic pain management in primary care is a pressing public health concern…”
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Multifunctional protein-encapsulated polycaprolactone scaffolds: Fabrication and in vitro assessment for tissue engineering by Ozkan, Seher, Kalyon, Dilhan M, Yu, Xiaojun, McKelvey, Craig A, Lowinger, Michael

“…Abstract Here we demonstrate the use of a twin screw extrusion/spiral winding (TSESW) process to generate protein-encapsulated tissue engineering scaffolds…”
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Valaciclovir for Epstein-Barr Virus Suppression in Moderate-to-Severe COPD: A Randomized Double-Blind Placebo-Controlled Trial by Linden, Dermot A, Guo-Parke, Hong, McKelvey, Michael C, Einarsson, Gisli G, Lee, Andrew J, Fairley, Derek J, Brown, Vanessa, Lundy, Gavin, Campbell, Christina, Logan, Danielle, McFarland, Margaret, Singh, Dave, McAuley, Daniel F, Taggart, Clifford C, Kidney, Joseph C

“…Epstein-Barr virus (EBV) frequently is measured at high levels in COPD using sputum quantitative polymerase chain reaction, whereas airway immunohistochemistry…”
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Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome by McKelvey, Michael C, Abladey, Anthony A, Small, Donna M, Doherty, Declan F, Williams, Richard, Scott, Aaron, Spek, C Arnold, Borensztajn, Keren S, Holsinger, Leslie, Booth, Robert, O'Kane, Cecilia M, McAuley, Daniel F, Taggart, Clifford C, Weldon, Sinéad

“…Although the cysteine protease cathepsin S has been implicated in the pathogenesis of several inflammatory lung diseases, its role has not been examined in the…”
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KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation by Lockwood, Karina C., Lear, Travis B., Rajbhandari, Shristi, McKelvey, Alison C., Dunn, Sarah R., Boudreau, Áine N., Liu, Yuan, Chen, Bill B.

“…Dysregulated cytokine signalling is a hallmark of inflammatory bowel diseases. Inflammatory responses of the colon are regulated by the suppressor of cytokine…”
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Price, unit value, and quality demanded by McKelvey, Christopher

“…Given the paucity of quality price data, it is common to rely on “unit value” (average expenditure per unit) as a proxy for price, but this is an imperfect…”
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