Search Results - "McKell, Melanie C"

Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack by Oates, Jarren R, McKell, Melanie C, Moreno-Fernandez, Maria E, Damen, Michelle S M A, Deepe, Jr, George S, Qualls, Joseph E, Divanovic, Senad

“…Obesity is a prevalent predisposing factor to non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in the developed world. NAFLD…”
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Restraint of Fumarate Accrual by HIF-1α Preserves miR-27a-Mediated Limitation of Interleukin 10 during Infection of Macrophages by Histoplasma capsulatum by Evans, Heather M, Schultz, Destiny F, Boiman, Adam J, McKell, Melanie C, Qualls, Joseph E, Deepe, Jr, George S

“…Hypoxia-inducible factor 1α (HIF-1α) regulates the immunometabolic phenotype of macrophages, including the orchestration of inflammatory and antimicrobial…”
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Promotion of Anti-Tuberculosis Macrophage Activity by L-Arginine in the Absence of Nitric Oxide by McKell, Melanie C., Crowther, Rebecca R., Schmidt, Stephanie M., Robillard, Michelle C., Cantrell, Rachel, Lehn, Maria A., Janssen, Edith M., Qualls, Joseph E.

“…Macrophages are indispensable immune cells tasked at eliminating intracellular pathogens. Mycobacterium tuberculosis ( Mtb ), one of the most virulent…”
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l-Citrulline Metabolism in Mice Augments CD4 + T Cell Proliferation and Cytokine Production In Vitro , and Accumulation in the Mycobacteria-Infected Lung by Lange, Shannon M, McKell, Melanie C, Schmidt, Stephanie M, Hossfeld, Austin P, Chaturvedi, Vandana, Kinder, Jeremy M, McAlees, Jaclyn W, Lewkowich, Ian P, Way, Sing Sing, Turner, Joanne, Qualls, Joseph E

“…Activation, recruitment, and effector function of T lymphocytes are essential for control of mycobacterial infection. These processes are tightly regulated in…”
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Adenovirus-Mediated Delivery of Decoy Hyper Binding Sites Targeting Oncogenic HMGA1 Reduces Pancreatic and Liver Cancer Cell Viability by Hassan, Faizule, Ni, Shuisong, Arnett, Tyler C., McKell, Melanie C., Kennedy, Michael A.

“…High mobility group AT-hook 1 (HMGA1) protein is an oncogenic architectural transcription factor that plays an essential role in early development, but it is…”
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Cutting Edge: l-Arginine Transfer from Antigen-Presenting Cells Sustains CD4 + T Cell Viability and Proliferation by Crowther, Rebecca R, Schmidt, Stephanie M, Lange, Shannon M, McKell, Melanie C, Robillard, Michelle C, Zhao, Junfang, Haffey, Wendy D, Wyder, Michael A, Greis, Kenneth D, Setchell, Kenneth D R, Qualls, Joseph E

“…Metabolomics analyses suggest changes in amino acid abundance, particularly l-arginine (L-ARG), occur in patients with tuberculosis. Immune cells require L-ARG…”
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l-Arginine Synthesis from l-Citrulline in Myeloid Cells Drives Host Defense against Mycobacteria In Vivo by Lange, Shannon M, McKell, Melanie C, Schmidt, Stephanie M, Zhao, Junfang, Crowther, Rebecca R, Green, Lisa C, Bricker, Rebecca L, Arnett, Eusondia, Köhler, S Eleonore, Schlesinger, Larry S, Setchell, Kenneth D R, Qualls, Joseph E

“…Immunonutrition as a therapeutic approach is rapidly gaining interest in the fight against infection. Targeting l-arginine metabolism is intriguing,…”
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Cell type‐specific mechanisms coupling protease‐activated receptor‐1 to infectious colitis pathogenesis by Boucher, Alexander A., Rosenfeldt, Leah, Mureb, Duaa, Shafer, Jessica, Sharma, Bal Krishan, Lane, Adam, Crowther, Rebecca R., McKell, Melanie C., Whitt, Jordan, Alenghat, Theresa, Qualls, Joseph, Antoniak, Silvio, Mackman, Nigel, Flick, Matthew J., Steinbrecher, Kris A., Palumbo, Joseph S.

“…Background Protease‐activated receptor‐1 (PAR‐1) plays a major role in multiple disease processes, including colitis. Understanding the mechanisms coupling…”
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Dendritic Cells Supply CD4+ T Cells With L-arginine by Crowther, Rebecca R, Schmidt, Stephanie M, Zhao, Junfang, McKell, Melanie C, Setchell, Kenneth D, Qualls, Joseph E

“…Tuberculosis (TB), caused by Mycobacterium tuberculosis, is responsible for over 1 million deaths each year. Mycobacteria-infected dendritic cells (DCs)…”
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L-arginine transfer from antigen presenting cells sustains CD4+ T cell viability and proliferation by Crowther, Rebecca R., Schmidt, Stephanie M., Lange, Shannon M., McKell, Melanie C., Robillard, Michelle C., Zhao, Junfang, Haffey, Wendy D., Wyder, Michael A., Greis, Kenneth D., Setchell, Kenneth D. R., Qualls, Joseph E.

“…Metabolomics analyses suggest changes in amino acid abundance, particularly L-arginine (L-ARG), occur in tuberculosis patients. Immune cells require L-ARG to…”
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