Search Results - "McKee, Laurel"

Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25 by Chen, Hao, Untiveros, Gustavo M, McKee, Laurel A K, Perez, Jessica, Li, Jing, Antin, Parker B, Konhilas, John P

“…Recently, MicroRNAs (miR) and AMP-kinase (AMPK) have emerged as prominent players in the development of cardiac hypertrophy and heart failure. We hypothesized…”
Get full text

LKB1/Mo25/STRAD Uniquely Impacts Sarcomeric Contractile Function and Posttranslational Modification by Behunin, Samantha M., Lopez-Pier, Marissa A., Birch, Camille L., McKee, Laurel A.K., Danilo, Christiane, Khalpey, Zain, Konhilas, John P.

“…The myocardium undergoes extensive metabolic and energetic remodeling during the progression of cardiac disease. Central to remodeling are changes in the…”
Get full text

Using 4-vinylcyclohexene diepoxide as a model of menopause for cardiovascular disease by Konhilas, John P, Sanchez, Jessica N, Regan, Jessica A, Constantopoulos, Eleni, Lopez-Pier, Marissa, Cannon, Danielle K, Skaria, Rinku, McKee, Laurel A, Chen, Hao, Lipovka, Yulia, Pollow, Dennis, Brooks, Heddwen L

“…There is a sharp rise in cardiovascular disease (CVD) risk and progression with the onset of menopause. The 4-vinylcyclohexene diepoxide (VCD) model of…”
Get more information

Sexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy mice by McKee, Laurel A.K., Chen, Hao, Regan, Jessica A., Behunin, Samantha M., Walker, Jeffery W., Walker, John S., Konhilas, John P.

“…► 10–12Month HCM females develop proportionately larger hearts than HCM males. ► HCM females display alterations in Ca2+-sensitivity over female WT; HCM males…”
Get full text

Diet and sex modify exercise and cardiac adaptation in the mouse by Konhilas, John P, Chen, Hao, Luczak, Elizabeth, McKee, Laurel A, Regan, Jessica, Watson, Peter A, Stauffer, Brian L, Khalpey, Zain I, Mckinsey, Timothy A, Horn, Todd, LaFleur, Bonnie, Leinwand, Leslie A

“…The heart adapts to exercise stimuli in a sex-dimorphic manner when mice are fed the traditional soy-based chow. Females undergo more voluntary exercise (4 wk)…”
Get more information

Development of an Immunohistochemical Assay to Detect the Ataxia-Telangiectasia Mutated (ATM) Protein in Gastric Carcinoma by Miller, Rachel M., Nworu, Chinedu, McKee, Laurel, Balcerzak, Denis, Pham, Linh, Pugh, Judith, Liu, Yu-Zhen, Gustafson, Heather, Marwah, Ekta, Lamb, Tiffany, Clements, June

“…Ataxia-telangiectasia mutated (ATM), a key activator of DNA damage response mechanisms, represents a potential biomarker for targeted gastric carcinoma…”
Get full text

Temporal and morphological impact of pressure overload in transgenic FHC mice by Chen, Hao, Hwang, Hyosook, McKee, Laurel A K, Perez, Jessica N, Regan, Jessica A, Constantopoulos, Eleni, Lafleur, Bonnie, Konhilas, John P

“…Although familial hypertrophic cardiomyopathy (FHC) is characterized as cardiac disease in the absence of overt stressors, disease penetrance, and pathological…”
Get full text

Abstract P196: The Impact of MicroRNA195 on the Lkb1/AMPK Signaling Axis and Hypertrophic Cardiomyopathy by Chen, Hao, Mckee, Laurel, Untiveros, Gustavo, Perez, Jessica, Konhilas, John

“…Abstract only Objectives: MicroRNAs (miRs) have been identified as chief post-transcriptional regulators of cardiac disease progression. In addition, a…”
Get full text

Inhibition of Ovarian KIT Phosphorylation by the Ovotoxicant 4-Vinylcyclohexene Diepoxide in Rats by MARK-KAPPELER, Connie J, SEN, Nivedita, LUKEFAHR, Ashley, MCKEE, Laurel, GLENN SIPES, I, KONHILAS, John, HOYER, Patricia B

“…In vitro exposure of Postnatal Day 4 (PND4) rat ovaries to the occupational chemical 4-vinylcyclohexene diepoxide (VCD) destroys specifically primordial and…”
Get full text

Target Specific Phosphorylation of Cardiac Troponin I and Sex Dimorphic Myofilament Function in R403Q Mice by McKee, Laurel, Regan, Jessica, Chen, Hao, Walker, John, Leinwand, Leslie A., Konhilas, John P.

Get full text

A method to study the impact of chemically-induced ovarian failure on exercise capacity and cardiac adaptation in mice by Chen, Hao, Perez, Jessica N, Constantopoulos, Eleni, McKee, Laurel, Regan, Jessica, Hoyer, Patricia B, Brooks, Heddwen L, Konhilas, John

“…The risk of cardiovascular disease (CVD) increases in post-menopausal women, yet, the role of exercise, as a preventative measure for CVD risk in…”
Get full text

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice by Chen, Hao, Perez, Jessica N., Constantopoulos, Eleni, McKee, Laurel, Regan, Jessica, Hoyer, Patricia B., Brooks, Heddwen L., Konhilas, John

Get full text

Inhibition of Ovarian KIT Phosphorylation by the Ovotoxicant 4-Vinylcyclohexene Diepoxide in Rats1 by Mark-Kappeler, Connie J, Sen, Nivedita, Lukefahr, Ashley, McKee, Laurel, Sipes, I. Glenn, Konhilas, John, Hoyer, Patricia B

“…In vitro exposure of Postnatal Day 4 (PND4) rat ovaries to the occupational chemical 4-vinylcyclohexene diepoxide (VCD) destroys specifically primordial and…”
Get full text

Temporal and morphological impact of pressure overload in R403Q mutant mice by Hao eChen, Hyosook eHwang, Laurel A.K. McKee, Jessica N Perez, Jessica A Regan, Eleni eConstantopoulos, Bonnie eLaFleur, John Peter Konhilas

“…Although familial hypertrophic cardiomyopathy (FHC) is characterized as cardiac disease in the absence of overt stressors, disease penetrance and pathological…”
Get full text