Search Results - "McKee, Celia A."

Emerging Roles for the Immune System in Traumatic Brain Injury by McKee, Celia A, Lukens, John R

“…Traumatic brain injury (TBI) affects an ever-growing population of all ages with long-term consequences on health and cognition. Many of the issues that TBI…”
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Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis by Bolte, Ashley C., Dutta, Arun B., Hurt, Mariah E., Smirnov, Igor, Kovacs, Michael A., McKee, Celia A., Ennerfelt, Hannah E., Shapiro, Daniel, Nguyen, Bao H., Frost, Elizabeth L., Lammert, Catherine R., Kipnis, Jonathan, Lukens, John R.

“…Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model of TBI that mild forms of…”
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Dural lymphatics regulate clearance of extracellular tau from the CNS by Patel, Tirth K, Habimana-Griffin, LeMoyne, Gao, Xuefeng, Xu, Baogang, Achilefu, Samuel, Alitalo, Kari, McKee, Celia A, Sheehan, Patrick W, Musiek, Erik S, Xiong, Chengjie, Coble, Dean, Holtzman, David M

“…Alzheimer's disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (Aβ) protein and intracellular aggregates of…”
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Chi3l1 /YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis by Lananna, Brian V, McKee, Celia A, King, Melvin W, Del-Aguila, Jorge L, Dimitry, Julie M, Farias, Fabiana H G, Nadarajah, Collin J, Xiong, David D, Guo, Chun, Cammack, Alexander J, Elias, Jack A, Zhang, Jinsong, Cruchaga, Carlos, Musiek, Erik S

“…Regulation of glial activation and neuroinflammation are critical factors in the pathogenesis of Alzheimer's disease (AD). YKL-40, a primarily astrocytic…”
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Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden by McKee, Celia A., Lee, Jiyeon, Cai, Yuqi, Saito, Takashi, Saido, Takaomi, Musiek, Erik S.

“…An emerging link between circadian clock function and neurodegeneration has indicated a critical role for the molecular clock in brain health. We previously…”
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Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1 by Lananna, Brian V., Nadarajah, Collin J., Izumo, Mariko, Cedeño, Michelle R., Xiong, David D., Dimitry, Julie, Tso, Chak Foon, McKee, Celia A., Griffin, Percy, Sheehan, Patrick W., Haspel, Jeffery A., Barres, Ben A., Liddelow, Shane A., Takahashi, Joseph S., Karatsoreos, Ilia N., Musiek, Erik S.

“…Circadian clock dysfunction is a common symptom of aging and neurodegenerative diseases, though its impact on brain health is poorly understood. Astrocyte…”
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AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment by Lammert, Catherine R., Frost, Elizabeth L., Bellinger, Calli E., Bolte, Ashley C., McKee, Celia A., Hurt, Mariah E., Paysour, Matt J., Ennerfelt, Hannah E., Lukens, John R.

“…Neurodevelopment is characterized by rapid rates of neural cell proliferation and differentiation followed by massive cell death in which more than half of all…”
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Circadian regulation of astrocyte function: implications for Alzheimer’s disease by McKee, Celia A., Lananna, Brian V., Musiek, Erik S.

“…The circadian clock regulates rhythms in gene transcription that have a profound impact on cellular function, behavior, and disease. Circadian dysfunction is a…”
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Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes by McKee, Celia A, Polino, Alexander J, King, Melvin W, Musiek, Erik S

“…An emerging role for the circadian clock in autophagy and lysosome function has opened new avenues for exploration in the field of neurodegeneration. The daily…”
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Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis by Bolte, Ashley C, Hurt, Mariah E, Smirnov, Igor, Dutta, Arun B, Kovacs, Michael A, McKee, Celia A, Natale, Nick, Ennerfelt, Hannah E, Nguyen, Bao H, Frost, Elizabeth L, Lammert, Catherine E, Kipnis, Jonathan, Lukens, John R

“…Abstract Traumatic brain injury (TBI) has emerged as a leading cause of death and disability. Despite being a growing medical issue, the biological factors…”
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