Search Results - "McKearn, T."

203 MDS CONCEPTUAL FRAMEWORK IDENTIFIES UNMET NEED FOR HMA-UNRESPONSIVE AND TRANSPLANT-INELIGIBLE PATIENTS by Bentley, T, Broder, M, Megaffin, S, Petrone, M, McKearn, T, Kurtin, S, Cogle, C

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76 POPULATION INCIDENCE OF MDS FOLLOWING HYPOMETHYLATING AGENT (HMA) TREATMENT FAILURE: ANALYSIS OF US COMMERCIAL CLAIMS DATA by Cogle, C, Kurtin, S, Bentley, T, Broder, M, Chang, E, Lawrence, M, McKearn, T, Megaffin, S, Petrone, M

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A monoclonal antibody discriminating between subsets of T and B cells by Bruce, J, Symington, FW, McKearn, TJ, Sprent, J

“…A description is given of a rat anti-mouse hybridoma antibody, JIId, which reacts with erythrocytes, neutrophils, greater than 90% of thymus cells, and most B…”
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Site-Specific Covalent Modification of Monoclonal Antibodies: In vitro and in vivo Evaluations by Rodwell, John D., Alvarez, Vernon L., Lee, Chyi, Lopes, A. Dwight, John W. F. Goers, King, H. Dalton, Powsner, Henry J., McKearn, Thomas J.

“…A strategy for covalent modification of monoclonal antibodies utilizing the oxidized oligosaccharide moieties on the molecule was evaluated and compared to…”
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Radioimmunodetection of solid tumors. Future horizons and applications for radioimmunotherapy by McKearn, T J

“…Seventeen years after the development of hybridoma technology, the clinical utility of radioimmunodetection of solid tumors using monoclonal antibody-based…”
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Properties of rat anti-MHC antibodies produced by cloned rat-mouse hybridomas by McKearn, T J, Fitch, F W, Smilek, D E, Sarmiento, M, Stuart, F P

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Association of genetic polymorphisms in ERCC1 gene with PSA response to carboplatin chemotherapy in men with metastatic castration-resistant prostate cancer (CRPC) by Nakabayashi, M., Oh, W. K., Werner, L., Xie, W., Regan, M. M., McKearn, T. J., Kantoff, P., Pomerantz, M.

“…Abstract only…”
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Immunohistochemical application of monoclonal antibodies against myelin basic protein and neurofilament triple protein subunits: advantages over antisera and technical limitations by Hickey, WF, Lee, V, Trojanowski, JQ, McMillan, LJ, McKearn, TJ, Gonatas, J, Gonatas, NK

“…Four monoclonal antibodies against guinea pig myelin basic protein (MBP), and four against subunits of bovine neurofilament triplet proteins (NF) were produced…”
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Correlation of progression-free survival (PFS) and overall survival (OS) in men with metastatic castration-resistant prostate cancer (CRPC) who failed first-line chemotherapy: Results from the SPARC Trial by Halabi, S., Sartor, O., Petrylak, D., Sternberg, C. N., Witjes, J. A., Noursalehi, M., McKearn, T. J., George, M. J.

“…Abstract only 5150 Background: It has been shown in chemotherapy naïve patients that PFS is a statistically significant predictor of OS. The main objectives of…”
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Inhibition of mannosidase in hybridomas yields monoclonal antibodies with greater capacity for carbohydrate labeling by Simonson, R B, Ultee, M E, Long, C G, Gillette, R W, McKearn, T J, Rodwell, J D

“…Labeling an antibody site specifically through its carbohydrate residues preserves more of its antigen-binding activity than does labeling through protein…”
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Anti-Idiotypic Antibody in Rat Transplantation Immunity: I. Production of anti-Idiotypic Antibody in Animals Repeatedly Immunized with Alloantigens by McKearn, T. J, Stuart, F. P, Fitch, F. W

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Use of pain at baseline and pain progression to predict overall survival (OS) in patients (pts) with docetaxel pretreated metastatic castration-refractory prostate cancer (CRPC): Results from the SPARC trial by Sartor, A. O., Petrylak, D., Sternberg, C., Witjes, F., Halabi, S., Berry, W., Petrone, M., McKearn, T., Noursalehi, M., George, M.

“…Abstract only 5148 Background: First-line chemotherapy trials have reported that pain predicts OS in CRPC. We report relationships between OS and baseline pain…”
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Monoclonal rat anti-major histocompatibility complex antibodies display specificity for rat, mouse, and human target cells by Smilek, D E, Boyd, H C, Wilson, D B, Zmijewski, C M, Fitch, F W, McKearn, T J

“…24 monoclonal rat antibodies are described that are reactive with determinants encoded by the major histocompatibility complex (MHC) of the rat. These…”
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Future directions in tumor radioimmunodetection by McKearn, T J

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Monoclonal Antibody Directed to a B-Cell Antigen Present in Rats, Mice, and Humans by Gasser, David L., Winters, B. Alleen, Haas, Jean B., McKearn, Thomas J., Kennett, Roger H.

“…Spleen cells from a LEW.AVN rat immunized with cells from an MNR rat were fused with mouse myeloma cells to produce hybrid cell lines. One of these hybridomas…”
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Anti-receptor antibody and resistance to graft- versus -host disease by MCKEARN, T. J, HAMADA, Y, STUART, F. P, FITCH, F. W

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Enhancement of rat renal allografts with idiotypic and antiidiotypic monoclonal alloantibodies by Stuart, F P, Fitch, F W, McKearn, T J

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Class I major histocompatibility gene products of the brown Norway rat display two major antigenic regions by Klinman, DM, Smilek, DE, McKearn, TJ

“…Sixteen Lewis anti-Brown Norway monoclonal antibodies and sera from alloimmunized Lewis rats were used to study the topographic relationships of antigenic…”
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Immunological enhancement of renal allografts by antireceptor antibody by Stuart, F P, McKearn, T J, Fitch, F W

“…Lewis (L) rats treated with donor antigen [Lewis Brown-Norway (LBN) spleen cells] and antidonor antibody (L anti-BN serum) produce L anti-(L anti-BN) antibody…”
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Selective suppression of humoral and cell-mediated immune responses to rat alloantigens by monoclonal antibodies produced by hybridoma cell lines by McKearn, T J, Weiss, A, Stuart, F P, Fitch, F W

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