Search Results - "McKearn, J P"

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines by Nunez, G, London, L, Hockenbery, D, Alexander, M, McKearn, JP, Korsmeyer, SJ

“…The t(14;18) of human follicular B cell lymphoma translocates the Bcl-2 gene into the Ig H chain locus and markedly deregulates Bcl-2 expression. We sought to…”
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bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation by McDonnell, T J, Deane, N, Platt, F M, Nunez, G, Jaeger, U, McKearn, J P, Korsmeyer, S J

“…Human follicular B cell lymphomas possess a t(14;18) interchromosomal translocation that juxtaposes the putative proto-oncogene bcl-2 with the immunoglobulin…”
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Biochemical and immunological properties of cytokines conjugated to dendritic polymers by Lee, S C, Parthasarathy, R, Botwin, K, Kunneman, D, Rowold, E, Lange, G, Klover, J, Abegg, A, Zobel, J, Beck, T, Miller, T, Hood, W, Monahan, J, McKearn, J P, Jansson, R, Voliva, C F

“…Here we describe a post-translational modification of SC-63032, a variant of the species restricted, multi-lineage hematopoeitic factor human interleukin-3…”
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Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population by MCDONNELL, T. J, NUNEZ, G, PLATT, F. M, HOCKENBERRY, D, LONDON, L, MCKEARN, J. P, KORSMEYER, S. J

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cellular and developmental properties of fetal hematopoietic stem cells by Jordan, C T, McKearn, J P, Lemischka, I R

“…We have characterized the fetal totipotent hematopoietic stem cell using a novel strategy that integrates physical analysis of cell properties and genetic…”
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Myelopoietin, an engineered chimeric IL-3 and G-CSF receptor agonist, stimulates multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression by MacVittie, Thomas J., Farese, Ann M., Smith, Walter G., Baum, Charles M., Burton, Earl, McKearn, John P.

“…Myelopoietins (MPOs) constitute a family of engineered, chimeric molecules that bind and activate the IL-3 and G-CSF receptors on hematopoietic cells. This…”
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Combination Therapy for Radiation-Induced Bone Marrow Aplasia in Nonhuman Primates Using Synthokine SC-55494 and Recombinant Human Granulocyte Colony-Stimulating Factor by MacVittie, Thomas J., Farese, Ann M., Herodin, Francis, Grab, Lisa B., Baum, Charles M., McKearn, John P.

“…Combination cytokine therapy continues to be evaluated in an effort to stimulate muftilineage hematopoietic reconsfrtu-tion after bone marrow myelosuppression…”
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Phage display mutagenesis of the chimeric dual cytokine receptor agonist myelopoietin by LEE, S. C, IBDAH, R, VAN VALKENBURGH, C, ROWOLD, E, ABEGG, A, DONNELLY, A, KLOVER, J, MERLIN, S, MCKEARN, J. P

“…Myelopoietins comprise a class of chimeric cytokine receptor agonists consisting of an hIL-3 (human interleukin-3) receptor agonist and an hG-CSF (human…”
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The enhanced in vitro hematopoietic activity of leridistim, a chimeric dual G-CSF and IL-3 receptor agonist by ABEGG, A. L, VICKERY, L. E, GIRI, J. G, WELPLY, J. K, MCKEARN, J. P. P, SMITH, W. G, BREMER, M. E, DONNELLY, A. M, DOSHI, P. D, EVANS, M. L, THURMAN, T. L, BRAFORD, S. R, CAPARON, M. H, BAUER, S. C

“…The in vitro activity of leridistim was characterized for cell proliferation, generation of colony-forming units (CFU) and differentiation of CD34+ cells. In…”
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Enrichment of Hematopoietic Precursor Cells and Cloning of Multipotential B-Lymphocyte Precursors by McKearn, John P., McCubrey, James, Fagg, Barbara

“…A simple one-step isolation technique significantly enriched mouse fetal liver cells that respond to interleukin 3 (IL-3), a multilineage hematopoietic growth…”
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Inhaled misoprostol blocks guinea pig antigen-induced bronchoconstriction and airway inflammation by Smith, W G, Thompson, J M, Kowalski, D L, McKearn, J P

“…Inhaled E-type prostaglandins (PGE) have been shown to modulate responses to both allergic and nonallergic provocation. Misoprostol, a PGE1 analog, was…”
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Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells by MCCUBREY, J. A, BLALOCK, W. L, DOSHI, P. D, MCKEARN, J. P, SALEH, O, PEARCE, M, BURROWS, C, STEELMAN, L. S, LEE, J. T, FRANKLIN, R. A, OBERHAUS, S. M, MOYE, P. W

“…Modified and chimeric cytokines have been developed to aid in the recovery of hematopoietic precursor cells after myeloablative chemotherapy. The interleukin-3…”
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Immunoglobulin λ Light-Chain-Related Genes 14.1 and 16.1 are Expressed in Pre-B Cells and may Encode the Human Immunoglobulin ω Light-Chain Protein by Hollis, Gregory F., Evans, Robert J., Stafford-Hollis, Jeannine M., Korsmeyer, Stanley J., McKearn, John P.

“…Human pre-B cells, which produce immunoglobulin heavy chain but do not produce immunoglobulin light chain, are shown to contain a 1-kilobase transcript…”
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Acceleration of Hematopoietic Reconstitution With a Synthetic Cytokine (SC-55494) After Radiation-Induced Bone Marrow Aplasia by Farese, Ann M., Herodin, Francis, McKearn, John P., Baum, Charles, Burton, Earl, MacVittie, Thomas J.

“…The synthetic cytokine (Synthokine) SC-55494 is a high-affinity interleukin-3 (IL-3) receptor ligand that stimulates greater in vitro multilineage…”
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Potent Interleukin 3 Receptor Agonist with Selectively Enhanced Hematopoietic Activity Relative to Recombinant Human Interleukin 3 by Thomas, John W., Baum, Charles M., Hood, William F., Klein, Barbara, Monahan, Joseph B., Paik, Kumnan, Staten, Nicholas, Abrams, Mark, McKearn, John P.

“…A systematic evaluation of structure-activity information led to the construction of genetically engineered interleukin 3 (IL-3) receptor agonists…”
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Cell surface antigens expressed by subsets of pre-B cells and B cells by McKearn, JP, Baum, C, Davie, JM

“…A large number of monoclonal antibodies, produced by immunizing rats with mouse pre-B cell lines, have been analyzed for their ability to define cell surface…”
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Modulation of the Binding Affinity of Myelopoietins for the Interleukin-3 Receptor by the Granulocyte Colony-Stimulating Factor Receptor Agonist by Hood, William F, Feng, Yiqing G, Schilling, Roger J, Gokarn, Yatin, Jarvis, Cindy, Remsen, Edward E, Shieh, Jeng-Jong J, Joy, William, Klein, Barbara K, Polazzi, Joseph O, Welply, Joseph K, McKearn, John P, Monahan, Joseph B

“…Myelopoietins (MPOs) are a family of recombinant chimeric proteins that are both interleukin-3 (IL-3) receptor and granulocyte colony-stimulating factor…”
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The dual regulatory role of interleukin 4 is mediated through a direct effect on the target cell by London, L, McKearn, J P

“…The mechanisms responsible for regulating the growth and differentiation of pluripotent stem cells involve the complex interaction of a series of specific and…”
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Phage presentation and affinity selection of a deletion mutant of human interleukin-3 by MERLIN, S, ROWOLD, E, ABEGG, A, BERGLUND, C, KLOVER, J, STATEN, N, MCKEARN, J. P, LEE, S. C

“…A deletion derivative of the cytokine human interleukin-3 (hIL-3(15-125), comprising amino acids 15-125 of the native protein) was produced as a fusion to the…”
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Activation and growth of colony-stimulating factor-dependent cell lines is cell cycle stage dependent by LONDON, L, MCKEARN, J. P

“…Hematopoietic cell development is regulated by a series of growth factors that are progressively restricted in their biological activity. IL-3 is a…”
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