Search Results - "McKean, DJ"

Dendritic cell modulation by 1α,25 dihydroxyvitamin D 3 and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo by Griffin, Matthew D., Lutz, Ward, Phan, Vy A., Bachman, Lori A., McKean, David J., Kumar, Rajiv

“…Dendritic cells (DCs) play a central role in regulating immune activation and responses to self. DC maturation is central to the outcome of antigen…”
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Augmentation of T Cell Levels and Responses Induced by Androgen Deprivation by Roden, Anja C, Moser, Michael T, Tri, Samuel D, Mercader, Maria, Kuntz, Susan M, Dong, Haidong, Hurwitz, Arthur A, McKean, David J, Celis, Esteban, Leibovich, Bradley C, Allison, James P, Kwon, Eugene D

“…Androgen has been implicated as a negative regulator of host immune function and a factor contributing to the gender dimorphism of autoimmunity. Conversely,…”
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Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse by Billadeau, Daniel D, Gomez, Timothy S, Hamann, Michael J, McCarney, Sean, Savoy, Doris N, Lubking, Casey M, Heldebrant, Michael P, Labno, Christine M, McKean, David J, McNiven, Mark A, Burkhardt, Janis K

“…Actin reorganization at the immunological synapse is required for the amplification and generation of a functional immune response. Using small interfering…”
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Selective inhibition of inflammatory gene expression in activated T lymphocytes: a mechanism of immune suppression by thiopurines by Thomas, Carlton W, Myhre, Gennett M, Tschumper, Renee, Sreekumar, Raghavakaimal, Jelinek, Diane, McKean, David J, Lipsky, James J, Sandborn, William J, Egan, Laurence J

“…Azathioprine and 6-mercaptopurine are antimetabolite thiopurine drugs that play important roles in the treatment of leukemia and in the management of…”
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Potent Inhibition of Dendritic Cell Differentiation and Maturation by Vitamin D Analogs by Griffin, Matthew D., Lutz, Ward H., Phan, Vy A., Bachman, Lori A., McKean, David J., Kumar, Rajiv

“…We show that the immunosuppressive effects of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) are due, in part, to inhibition of the T cell stimulatory functions of…”
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Ly9 (CD229)-Deficient Mice Exhibit T Cell Defects yet Do Not Share Several Phenotypic Characteristics Associated with SLAM- and SAP-Deficient Mice by Graham, Daniel B, Bell, Michael P, McCausland, Megan M, Huntoon, Catherine J, van Deursen, Jan, Faubion, William A, Crotty, Shane, McKean, David J

“…Signaling lymphocyte activation molecule (SLAM) family receptors are critically involved in modulating innate and adaptive immune responses. Several SLAM…”
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Distinctive dendritic cell modulation by vitamin D 3 and glucocorticoid pathways by Xing, Nianzeng, L. Maldonado, Monica, Bachman, Lori A, McKean, David J, Kumar, Rajiv, Griffin, Matthew D

“…Dendritic cell (DC) maturation plays a central role in regulating immunity. We show that glucocorticoid and 1α,25(OH) 2D 3 agonists modulate DCs via distinct…”
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Inhibition of Interleukin-1-stimulated NF-κB RelA/p65 Phosphorylation by Mesalamine Is Accompanied by Decreased Transcriptional Activity by Egan, Laurence J., Mays, Dennis C., Huntoon, Catherine J., Bell, Michael P., Pike, M. Gennett, Sandborn, William J., Lipsky, James J., McKean, David J.

“…Nuclear factor κB (NF-κB) is an inducible transcription factor that regulates genes important in immunity and inflammation. The activity of NF-κB is highly…”
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Interleukin-1 signal transduction by Bankers-Fulbright, Jennifer L., Kalli, Kimberly R., McKean, David J.

“…Interleukin-1 (IL-1) is primarily an inflammatory cytokine, although it is capable of mediating a wide variety of effects on many different cell types. Nearly…”
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Mechanism Responsible for T-Cell Antigen Receptor- and CD28- or Interleukin 1 (IL-1) Receptor-Initiated Regulation of IL-2 Gene Expression by NF-κB by Kalli, Kimberly, Huntoon, Catherine, Bell, Michael, McKean, David J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line by Karnitz, L, Sutor, S L, Torigoe, T, Reed, J C, Bell, M P, McKean, D J, Leibson, P J, Abraham, R T

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The analysis of costimulatory receptor signaling cascades in normal T lymphocytes using in vitro gene transfer and reporter gene analysis by McKean, David J, Bell, Michael P, Huntoon, Catherine J, Graham, Daniel

“…Ligation of the antigen receptor and costimulatory receptors on the surface of T lymphocytes initiates intracellular signals that regulate cell-cycle…”
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Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1- binding promoter element by Hedin, KE, Bell, MP, Kalli, KR, Huntoon, CJ, Sharp, BM, McKean, DJ

“…Recent molecular evidence points to transient and/or stage-specific expression of delta- and kappa-opioid receptors by thymic and peripheral T lymphocytes…”
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Maturation Versus Death of Developing Double-Positive Thymocytes Reflects Competing Effects on Bcl-2 Expression and Can Be Regulated by the Intensity of CD28 Costimulation by McKean, David J, Huntoon, Catherine J, Bell, Michael P, Tai, Xuguang, Sharrow, Susan, Hedin, Karen E, Conley, Abigail, Singer, Alfred

“…Immature double-positive (DP) thymocytes mature into CD4(+)CD8(-) cells in response to coengagement of TCR with any of a variety of cell surface "coinducer"…”
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Increased thymic output in HIV-negative patients after antiretroviral therapy by GRAHAM, Daniel B, BELL, Michael P, HUNTOON, Catherine J, WEAVER, Joel G. R, HAWLEY, Nanci, BADLEY, Andrew D, MCKEAN, David J

“…To determine the effects of antiretroviral therapy on thymic output independent of HIV infection. Thymic output was evaluated by quantifying signal joint…”
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Aglycosylated and phosphatidylinositol-anchored MHC class I molecules are associated with calnexin. Evidence implicating the class I- connecting peptide segment in calnexin association by Carreno, BM, Schreiber, KL, McKean, DJ, Stroynowski, I, Hansen, TH

“…The endoplasmic reticulum resident protein calnexin interacts with several glycoproteins including class I MHC molecules. Calnexin is thought to retain free…”
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Dual Signal Transduction through Delta Opioid Receptors in a Transfected Human T-Cell Line by Sharp, Burt M., Shahabi, Nahid A., Heagy, Wyrta, McAllen, Kathy, Bell, Michael, Huntoon, Cathy, McKean, David J.

“…Opiates are known to function as immunomodulators, in part by effects on T cells. However, the signal transduction pathways mediating the effects of opiates on…”
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Molecular cloning of the human eosinophil peroxidase: evidence for the existence of a peroxidase multigene family by TEN, R. M, PEASE, L. R, MCKEAN, D. J, BELL, M. P, GLEICH, G. J

“…Human eosinophil peroxidase (EPO) was purified from eosinophil granules derived from the peripheral blood of patients with eosinophilia. The molecular mass of…”
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Regulatory effects of transforming growth factor-beta on IL-2- and IL-4- dependent T cell-cycle progression by Ruegemer, JJ, Ho, SN, Augustine, JA, Schlager, JW, Bell, MP, McKean, DJ, Abraham, RT

“…Previous studies suggested that the potent immunosuppressive activities of transforming growth factor-beta (TGF-beta) were mediated in part through the…”
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Ribonuclease activity associated with human eosinophil-derived neurotoxin and eosinophil cationic protein by Slifman, NR, Loegering, DA, McKean, DJ, Gleich, GJ

“…The eosinophil granule contains a series of basic proteins, including major basic protein, eosinophil peroxidase, eosinophil-derived neurotoxin (EDN), and…”
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