Search Results - "McKay, Zachary P."

Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling by Brown, Michael C., Mosaheb, Mubeen M., Mohme, Malte, McKay, Zachary P., Holl, Eda K., Kastan, Jonathan P., Yang, Yuanfan, Beasley, Georgia M., Hwang, E. Shelley, Ashley, David M., Bigner, Darell D., Nair, Smita K., Gromeier, Matthias

“…Activating intra-tumor innate immunity might enhance tumor immune surveillance. Virotherapy is proposed to achieve tumor cell killing, while indirectly…”
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Early enterovirus translation deficits extend viral RNA replication and elicit sustained MDA5-directed innate signaling by Dobrikov, Mikhail I, Dobrikova, Elena Y, Nardone-White, Dasean T, McKay, Zachary P, Brown, Michael C, Gromeier, Matthias

“…Multiple pattern recognition receptors sense vRNAs and initiate downstream innate signaling: endosomal Toll-like receptors (TLRs) 3, 7, and 8 and cytoplasmic…”
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PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling by Dobrikov, Mikhail I, Dobrikova, Elena Y, McKay, Zachary P, Kastan, Jonathan P, Brown, Michael C, Gromeier, Matthias

“…For RNA virus families except , viral RNA sensing includes Toll-like receptors and/or RIG-I. Picornavirus RNAs, whose 5' termini are shielded by a…”
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Intratumor childhood vaccine-specific CD4+ T-cell recall coordinates antitumor CD8+ T cells and eosinophils by Brown, Michael C, Beasley, Georgia M, McKay, Zachary P, Yang, Yuanfan, Desjardins, Annick, Randazzo, Dina M, Landi, Daniel, Ashley, David M, Bigner, Darell D, Nair, Smita K, Gromeier, Matthias

“…BackgroundAntitumor mechanisms of CD4+ T cells remain crudely defined, and means to effectively harness CD4+ T-cell help for cancer immunotherapy are lacking…”
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Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression by McKay, Zachary P, Brown, Michael C, Gromeier, Matthias

“…Crosstalk between costimulatory and coinhibitory ligands are a prominent node of immune cell regulation. Mounting evidence points toward a critical role for…”
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Safety and efficacy of murine PVSRIPO plus anti-PD-1 immune checkpoint inhibitor (ICI) in a melanoma tumor model by Neighbours, Lauren, McKay, Zachary P, Gromeier, Matthias, Nichols, Garrett, Kelly, Andrea True, Corum, Daniel, Brown, Michael

“…Abstract only 2560 Background: Most patients with advanced melanoma (mel) fail/acquire resistance to ICI, including anti-(α) PD-1. PVSRIPO is a novel…”
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Abstract 2073: Childhood vaccine-specific CD4+T cell recall coordinates antitumor type I and II immunity by Brown, Michael Clavon, Mckay, Zachary P., Yang, Yuanfan, Bigner, Darell D., Nair, Smita K., Gromeier, Matthias

“…Abstract A recombinant poliovirus (rPV) derived from the live-attenuated Sabin oral polio vaccine strain, is being tested in multi-institutional phase II…”
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