Search Results - "McKay, Jennifer S"

AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models by Davies, Barry R, Logie, Armelle, McKay, Jennifer S, Martin, Paul, Steele, Samantha, Jenkins, Richard, Cockerill, Mark, Cartlidge, Sue, Smith, Paul D

“…Constitutive activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signaling pathway in human cancers is…”
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Validation of a Liquid Biopsy Protocol for Canine BRAFV595E Variant Detection in Dog Urine and Its Evaluation as a Diagnostic Test Complementary to Cytology by Gentilini, Fabio, Palgrave, Christopher J., Neta, Michal, Tornago, Raimondo, Furlanello, Tommaso, McKay, Jennifer S., Sacchini, Federico, Turba, Maria E.

“…A significant proportion of canine urothelial carcinomas carry the driver valine to glutamic acid variation (V595E) in BRAF kinase. The detection of V595E may…”
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Recommendations for Pathology Peer Review by Morton, Daniel, Sellers, Rani S., Barale-Thomas, Erio, Bolon, Brad, George, Catherine, Hardisty, Jerry F., Irizarry, Armando, McKay, Jennifer S., Odin, Marielle, Teranishi, Munehiro

“…Pathology peer review verifies and improves the accuracy and quality of pathology diagnoses and interpretations. Pathology peer review is recommended when…”
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Evaluation of a convenient method of assessing rodent visual function in safety pharmacology studies: Effects of sodium iodate on visual acuity and retinal morphology in albino and pigmented rats and mice by Redfern, William S., Storey, Sharon, Tse, Karen, Hussain, Qasim, Maung, Khine Phu, Valentin, Jean-Pierre, Ahmed, Gulshanara, Bigley, Alison, Heathcote, Dan, McKay, Jennifer S.

“…We have evaluated the ability of a semi-automated, optomotor reflex method to assess drug-induced visual dysfunction, in albino and pigmented rats and mice…”
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Regulation of activity-dependent neuroprotective protein (ADNP) by the NO-cGMP pathway in the hippocampus during kainic acid-induced seizure by Cosgrave, Anna S, McKay, Jennifer S, Bubb, Vivien, Morris, Richard, Quinn, John P, Thippeswamy, Thimmasettappa

“…Abstract Activity-dependent neuroprotective protein (ADNP) is widely distributed in the cytoplasm of neurons and astrocytes of the hippocampus. Kainic acid…”
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Gene expression analysis of Canine Demodicosis; A milieu promoting immune tolerance by Kelly, Pamela A., Browne, John, Peters, Susan, Bell, Frazer, McKay, Jennifer S., Lara-Saez, Irene, Breathnach, Rory

“…Canine demodicosis is a common skin disease seen in companion animal practice that results from an overpopulation of the commensal Demodex mite species. Common…”
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Proceedings of the 2010 National Toxicology Program Satellite Symposium by Adams, E. Terence, Auerbach, Scott, Blackshear, Pamela E., Bradley, Alys, Gruebbel, Margarita M., Little, Peter B., Malarkey, David, Maronpot, Robert, McKay, Jennifer S., Miller, Rodney A., Moore, Rebecca R., Morrison, James P., Nyska, Abraham, Ramot, Yuval, Rao, Deepa, Suttie, Andrew, Wells, Monique Y., Willson, Gabrielle A., Elmore, Susan A.

“…The 2010 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri,” was held in Chicago, Illinois, in advance of the…”
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A retrospective study of cases of canine demodicosis submitted to a commercial diagnostic laboratory servicing the United Kingdom and Ireland (2017–2018) part 2; Aerobic culture and antimicrobial susceptibility results by Kelly, Pamela A., McKay, Jennifer S., Maguire, David, Jones, Matthew, Roberts, Larry, Powell, Frank, Breathnach, Rory

“…Clinical diagnostic reports from 508 cases of canine demodicosis diagnosed either by histological or skin scraping analysis from a United Kingdom Accreditation…”
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A retrospective study of cases of canine demodicosis submitted to a commercial diagnostic laboratory servicing the United Kingdom and Ireland (2017–2018): Part 1 – Signalment, lesion distribution, treatments, and concurrent diseases by Kelly, Pamela A., McKay, Jennifer S., Maguire, David, Jones, Matthew, Roberts, Larry, Powell, Frank, Breathnach, Rory

“…Canine demodicosis, due to an overpopulation of Demodex spp. mites, remains one of the most common dermatological diseases encountered in small animal…”
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A Commentary on the Process of Peer Review and Pathology Data Locking by McKay, Jennifer S., Barale-Thomas, Erio, Bolon, Brad, George, Catherine, Hardisty, Jerry, Manabe, Sunao, Schorsch, Frédéric, Teranishi, Munehiro, Weber, Klaus

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Unveiling the Role of Endoplasmic Reticulum Stress Pathways in Canine Demodicosis by Kelly, Pamela A., McHugo, Gillian P., Scaife, Caitriona, Peters, Susan, Stevenson, M. Lynn, McKay, Jennifer S., MacHugh, David E., Saez, Irene Lara, Breathnach, Rory

“…ABSTRACT Canine demodicosis is a prevalent skin disease caused by overpopulation of a commensal species of Demodex mite, yet its precise cause remains unknown…”
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An antibody panel for immunohistochemical analysis of the retina in Davidson's-fixed, paraffin-embedded eyes of rats by McKay, Jennifer S., Steele, Samantha J., Ahmed, Gulshanara, Johnson, Elizabeth, Ratcliffe, Kerry

“…Unlike most other tissues, the optimal fixative for preserving eye morphology is considered to be Davidson's fixative or modified Davidson's rather than…”
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Nitric oxide-NGF mediated PPTA/SP, ADNP, and VIP expression in the peripheral nervous system by Thippeswamy, Thimmasettappa, Howard, Mark R, Cosgrave, Anna Siobhan, Arora, Daleep Kumar, McKay, Jennifer S, Quinn, John P

“…Nerve growth factor (NGF)-deprivation or axotomy of dorsal root ganglion (DRG) neurons causes stress, which they cope by triggering various mechanisms. Among…”
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Determination of the safety and efficacy of therapeutic neutralization of tumor necrosis factor-α (TNF-α) using AZD9773, an anti-TNF-α immune Fab, in murine CLP sepsis by Newham, Peter, Ross, Daniel, Ceuppens, Peter, Das, Shampa, Yates, James W. T., Betts, Catherine, Reens, Jaimini, Randall, Kevin J., Knight, Richard, McKay, Jennifer S.

“…Objective and design TNF-α neutralization is associated with increased mortality in mouse cecal ligation puncture (CLP) models. AZD9773 is an ovine polyclonal…”
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Either nitric oxide or nerve growth factor is required for dorsal root ganglion neurons to survive during embryonic and neonatal development by Thippeswamy, Thimmasettappa, McKay, Jennifer S., Quinn, John, Morris, Richard

“…During early embryonic (E12) development almost all dorsal root ganglion (DRG) neurons express the neuronal isoform of nitric oxide synthase (nNOS). At this…”
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Differential Regulation of Vasoactive Intestinal Peptide (VIP) in the Dentate Gyrus and Hippocampus via the NO-cGMP Pathway Following Kainic Acid-Induced Seizure in the Rat by Cosgrave, Anna Siobhan, McKay, Jennifer S., Thippeswamy, Thimmasettappa

“…We have previously shown that kainic acid (KA) increases nitric oxide (NO) synthase (NOS) production in the rat dentate gyrus (DG) and hippocampus (CA3), and…”
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Glial-mediated neuroprotection: Evidence for the protective role of the NO-cGMP pathway via neuron-glial communication in the peripheral nervous system by Thippeswamy, Thimmasettappa, Mckay, Jennifer S., Morris, Richard, Quinn, John, Wong, Liang-Fong, Murphy, David

“…The NO‐cGMP pathway has emerged as a neuroprotective signaling system involved in communication between neurons and glia. We have previously shown that axotomy…”
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The effects of nitric oxide inhibition prior to kainic acid treatment on neuro- and gliogenesis in the rat dentate gyrus in vivo and in vitro by Cosgrave, A Siobhan, McKay, Jennifer S, Morris, Richard, Quinn, John P, Thippeswamy, Thimmasettappa

“…Treatment with the nitric oxide synthase (NOS) inhibitor, L-NAME prior to the induction of seizures with kainic acid (KA) [L-NAME+KA] increases the expression…”
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Nitric Oxide Regulates Activity-Dependent Neuroprotective Protein (ADNP) in the Dentate Gyrus of the Rodent Model of Kainic Acid-Induced Seizure by Cosgrave, Anna S., McKay, Jennifer S., Morris, Richard, Quinn, John P., Thippeswamy, Thimmasettappa

“…The dentate gyrus (DG) of the normal rat brain contains activity-dependent neuroprotective protein (ADNP) which is widely distributed in the cytoplasm of…”
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A commentary on the process of peer review and pathology data locking by McKay, Jennifer S., Barale-Thomas, Erio, Bolon, Brad, George, Catherine, Hardisty, Jerry, Manabe, Sunao, Schorsch, Frédéric, Teranishi, Munehiro, Weber, Klaus

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