Search Results - "McKENZIE, GREGORY J."

Dosing a synbiotic of human milk oligosaccharides and B. infantis leads to reversible engraftment in healthy adult microbiomes without antibiotics by Button, Julie E., Autran, Chloe A., Reens, Abigail L., Cosetta, Casey M., Smriga, Steven, Ericson, Megan, Pierce, Jessica V., Cook, David N., Lee, Martin L., Sun, Adam K., Alousi, Amin M., Koh, Andrew Y., Rechtman, David J., Jenq, Robert R., McKenzie, Gregory J.

“…Predictable and sustainable engraftment of live biotherapeutic products into the human gut microbiome is being explored as a promising way to modulate the…”
Get full text

Tunable control of B. infantis abundance and gut metabolites by co-administration of human milk oligosaccharides by Reens, Abigail L, Cosetta, Casey M, Saur, Russell, Trofimuk, Olivia, Brooker, Sarah L, Lee, Martin L, Sun, Adam K, McKenzie, Gregory J, Button, Julie E

“…Precision engineering of the gut microbiome holds promise as an effective therapeutic approach for diseases associated with a disruption in this microbial…”
Get full text

Fast, easy and efficient: site-specific insertion of transgenes into enterobacterial chromosomes using Tn7 without need for selection of the insertion event by McKenzie, Gregory J, Craig, Nancy L

“…Inserting transgenes into bacterial chromosomes is generally quite involved, requiring a selection for cells carrying the insertion, usually for…”
Get full text

An SOS-Regulated Type 2 Toxin-Antitoxin System by SINGLETARY, Larissa A, GIBSON, Janet L, TANNER, Elizabeth J, MCKENZIE, Gregory J, LEE, Peter L, GONZALEZ, Caleb, ROSENBERG, Susan M

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The SOS Response Regulates Adaptive Mutation by McKenzie, Gregory J., Harris, Reuben S., Lee, Peter L., Rosenberg, Susan M.

“…Upon starvation some Escherichia coli cells undergo a transient, genome-wide hypermutation (called adaptive mutation) that is recombination-dependent and…”
Get full text

Characterization of the TnsD-attTn7 complex that promotes site-specific insertion of Tn7 by Mitra, Rupak, McKenzie, Gregory J, Yi, Liang, Lee, Cherline A, Craig, Nancy L

“…The bacterial transposon Tn7 is distinguished by its ability to recognize a specific site called attTn7, and insert just downstream of the highly conserved…”
Get full text

Manufacturing Processes of a Purified Microbiome Therapeutic Reduce Risk of Transmission of Potential Bacterial Pathogens in Donor Stool by McChalicher, Christopher W J, Lombardo, Mary-Jane, Khanna, Sahil, McKenzie, Gregory J, Halvorsen, Elizabeth M, Almomani, Sanabel, Schuster, Brian, Hasson, Brooke R, McGovern, Barbara H, Ege, David S, Auniņš, John G

“…Abstract Background Although fecal microbiota transplant has been used to prevent recurrent Clostridioides difficile infection (rCDI), documented pathogen…”
Get full text

The dinB Operon and Spontaneous Mutation in Escherichia coli by McKenzie, Gregory J, Magner, Daniel B, Lee, Peter L, Rosenberg, Susan M

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Precision modulation of dysbiotic adult microbiomes with a human-milk-derived synbiotic reshapes gut microbial composition and metabolites by Button, Julie E., Cosetta, Casey M., Reens, Abigail L., Brooker, Sarah L., Rowan-Nash, Aislinn D., Lavin, Richard C., Saur, Russell, Zheng, Shuning, Autran, Chloe A., Lee, Martin L., Sun, Adam K., Alousi, Amin M., Peterson, Christine B., Koh, Andrew Y., Rechtman, David J., Jenq, Robert R., McKenzie, Gregory J.

“…Manipulation of the gut microbiome using live biotherapeutic products shows promise for clinical applications but remains challenging to achieve. Here, we…”
Get full text

Long CTG Tracts from the Myotonic Dystrophy Gene Induce Deletions and Rearrangements during Recombination at the APRT Locus in CHO Cells by Meservy, James L., Sargent, R. Geoffrey, Iyer, Ravi R., Chan, Fung, McKenzie, Gregory J., Wells, Robert D., Wilson, John H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

SOS Mutator DNA Polymerase IV Functions in Adaptive Mutation and Not Adaptive Amplification by McKenzie, Gregory J, Lee, Peter L, Lombardo, Mary-Jane, Hastings, P.J, Rosenberg, Susan M

“…Adaptive point mutation and amplification are induced responses to environmental stress, promoting genetic changes that can enhance survival. A specialized…”
Get full text

Role of endogenous endonucleases and tissue site in transfection and CpG-mediated immune activation after naked DNA injection by Barry, M E, Pinto-González, D, Orson, F M, McKenzie, G J, Petry, G R, Barry, M A

“…DNA degradation is a fundamental problem for any gene therapy or genetic immunization approach, since destruction of incoming genes translates into loss of…”
Get more information

Evidence That Stationary-Phase Hypermutation in the Escherichia coli Chromosome Is Promoted by Recombination by Bull, Harold J, McKenzie, Gregory J, Hastings, P. J, Rosenberg, Susan M

“…Adaptive (or stationary-phase) mutation is a group of phenomena in which mutations appear to occur more often when selected than when not. They may represent…”
Get full text

Response to John Cairns: The Contribution of Transiently Hypermutable Cells to Mutation in Stationary Phase by Bull, Harold J, McKenzie, Gregory J, Hastings, P J, Rosenberg, Susan M

Get full text

WITHDRAWN:Manufacturing Process of Investigational Microbiome Therapeutic, SER-109, Reduces Risk of Bacterial Pathogen Transmission by McChalicher, Christopher W.J., Lombardo, Mary-Jane, Khanna, Sahil, McKenzie, Gregory J., McGovern, Barbara H., Auniņš, John G.

Get full text

Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogens by McKenzie, Gregory J., Rosenberg, Susan M.

“…‘Adaptive’ or ‘stationary-phase’ mutation is a collection of stress responses promoting mutations, some of which are advantageous. In 2000 and 2001, in…”
Get full text

Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogens : Genomics by MCKENZIE, Gregory J, ROSENBERG, Susan M

Get full text

Letter to the editor: Recombination-dependent mutation in Escherichia coli occurs in stationary phase by McKenzie, Gregory J, Lombardo, Mary-Jane, Rosenberg, Susan M

“…McKenzie et al discuss mutations occurring after plating in Escherichia coli cells. There is some question as to whether or not mutation occurs after plating…”
Get full text

Recombination-dependent mutation in Escherichia coli occurs in stationary phase by McKenzie, G J, Lombardo, M J, Rosenberg, S M

“…"Adaptive" or "stationary-phase" mutation occurs in apparently stationary-phase population of cells, over time, after exposure to a nonlethal selection. In one…”
Get full text

Mechanisms of Genome-Wide Hypermutation in Stationary Phasea by LOMBARDO, MARY-JANE, TORKELSON, JOEL, BULL, HAROLD J., McKENZIE, GREGORY J., ROSENBERG, SUSAN M.

“…Stationary‐phase mutation (a subset of which was previously called adaptive mutation) occurs in apparently nondividing, stationary‐phase cells exposed to a…”
Get full text