Search Results - "McIntyre, Rebecca L"

From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs by McIntyre, Rebecca L, Daniels, Eileen G, Molenaars, Marte, Houtkooper, Riekelt H, Janssens, Georges E

“…Reversing or slowing the aging process brings great promise to treat or prevent age‐related disease, and targeting the hallmarks of aging is a strategy to…”
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Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion by Liu, Yasmine J, Janssens, Georges E, McIntyre, Rebecca L, Molenaars, Marte, Kamble, Rashmi, Gao, Arwen W, Jongejan, Aldo, Weeghel, Michel van, MacInnes, Alyson W, Houtkooper, Riekelt H

“…The deregulation of metabolism is a hallmark of aging. As such, changes in the expression of metabolic genes and the profiles of amino acid levels are features…”
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Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models by Costa-Machado, Luis Filipe, Garcia-Dominguez, Esther, McIntyre, Rebecca L., Lopez-Aceituno, Jose Luis, Ballesteros-Gonzalez, Álvaro, Tapia-Gonzalez, Andrea, Fabregat-Safont, David, Eisenberg, Tobias, Gomez, Jesús, Plaza, Adrian, Sierra-Ramirez, Aranzazu, Perez, Manuel, Villanueva-Bermejo, David, Fornari, Tiziana, Loza, María Isabel, Herradon, Gonzalo, Hofer, Sebastian J., Magnes, Christoph, Madeo, Frank, Duerr, Janet S., Pozo, Oscar J., Galindo, Maximo-Ibo, del Pino, Isabel, Houtkooper, Riekelt H., Megias, Diego, Viña, Jose, Gomez-Cabrera, Mari Carmen, Fernandez-Marcos, Pablo J.

“…Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved…”
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Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction by van der Rijt, Sanne, Molenaars, Marte, McIntyre, Rebecca L, Janssens, Georges E, Houtkooper, Riekelt H

“…Since the identification and definition of the hallmarks of aging, these aspects of molecular and cellular decline have been most often described as isolated…”
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Anti-retroviral treatment with zidovudine alters pyrimidine metabolism, reduces translation, and extends healthy longevity via ATF-4 by McIntyre, Rebecca L., Molenaars, Marte, Schomakers, Bauke V., Gao, Arwen W., Kamble, Rashmi, Jongejan, Aldo, van Weeghel, Michel, van Kuilenburg, André B.P., Possemato, Richard, Houtkooper, Riekelt H., Janssens, Georges E.

“…The human population is aging, and the need for interventions to slow progression of age-related diseases (geroprotective interventions) is growing…”
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Considerations Regarding Public Use of Longevity Interventions by Liu, Yasmine J, McIntyre, Rebecca L, Janssens, Georges E

“…Public attention and interest for longevity interventions are growing. These can include dietary interventions such as intermittent fasting, physical…”
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Biological Age Prediction From Wearable Device Movement Data Identifies Nutritional and Pharmacological Interventions for Healthy Aging by McIntyre, Rebecca L., Rahman, Mizanur, Vanapalli, Siva A., Houtkooper, Riekelt H., Janssens, Georges E.

“…Intervening in aging processes is hypothesized to extend healthy years of life and treat age-related disease, thereby providing great benefit to society…”
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Low-dose naltrexone extends healthspan and lifespan in C. elegans via SKN-1 activation by Li, Weisha, McIntyre, Rebecca L., Schomakers, Bauke V., Kamble, Rashmi, Luesink, Anne H.G., van Weeghel, Michel, Houtkooper, Riekelt H., Gao, Arwen W., Janssens, Georges E.

“…As the global aging population rises, finding effective interventions to improve aging health is crucial. Drug repurposing, utilizing existing drugs for new…”
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Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease by Liu, Yasmine J., McIntyre, Rebecca L., Janssens, Georges E., Houtkooper, Riekelt H.

“…•Mitochondrial fission and fusion are implicated in age-related human pathologies.•Crucial to mitochondrial regulation is their dynamic nature in a network…”
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Cutting through dogma: a novel tool to dissect lactate biology by Rausch, Niclas, McIntyre, Rebecca L., Finger, Fabian, Lund, Jens

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Reduced nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice by Zapata‐Pérez, Rubén, Tammaro, Alessandra, Schomakers, Bauke V., Scantlebery, Angelique M. L., Denis, Simone, Elfrink, Hyung L., Giroud‐Gerbetant, Judith, Cantó, Carles, López‐Leonardo, Carmen, McIntyre, Rebecca L., van Weeghel, Michel, Sánchez‐Ferrer, Álvaro, Houtkooper, Riekelt H.

“…Nicotinamide adenine dinucleotide (NAD+) homeostasis is constantly compromised due to degradation by NAD+‐dependent enzymes. NAD+ replenishment by…”
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Repurposing nucleoside reverse transcriptase inhibitors (NRTIs) to slow aging by Brochard, Thomas, McIntyre, Rebecca L, Houtkooper, Riekelt H, Seluanov, Andrei, Gorbunova, Vera, Janssens, Georges E

“…Repurposing drugs already approved in the clinic to be used off-label as geroprotectors, compounds that combat mechanisms of aging, are a promising way to…”
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Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30 by Liu, Yasmine J, McIntyre, Rebecca L, Janssens, Georges E, Williams, Evan G, Lan, Jiayi, van Weeghel, Michel, Schomakers, Bauke, van der Veen, Henk, van der Wel, Nicole N, Yao, Pallas, Mair, William B, Aebersold, Ruedi, MacInnes, Alyson W, Houtkooper, Riekelt H

“…Mitochondrial form and function are closely interlinked in homeostasis and aging. Inhibiting mitochondrial translation is known to increase lifespan in C…”
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Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity by McIntyre, Rebecca L., Liu, Yasmine J., Hu, Man, Morris, Brian J., Willcox, Bradley J., Donlon, Timothy A., Houtkooper, Riekelt H., Janssens, Georges E.

“…Life expectancy has increased substantially over the last 150 years. Yet this means that now most people also spend a greater length of time suffering from…”
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Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF‐16‐induced longevity by McIntyre, Rebecca L., Denis, Simone W., Kamble, Rashmi, Molenaars, Marte, Petr, Michael, Schomakers, Bauke V., Rahman, Mizanur, Gupta, Siddhartha, Toth, Marton L., Vanapalli, Siva A., Jongejan, Aldo, Scheibye‐Knudsen, Morten, Houtkooper, Riekelt H., Janssens, Georges E.

“…Transcriptome‐based drug screening is emerging as a powerful tool to identify geroprotective compounds to intervene in age‐related disease. We hypothesized…”
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CIAO1 and MMS19 deficiency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders by van Karnebeek, Clara D.M., Tarailo-Graovac, Maja, Leen, René, Meinsma, Rutger, Correard, Solenne, Jansen-Meijer, Judith, Prykhozhij, Sergey V., Pena, Izabella A., Ban, Kevin, Schock, Sarah, Saxena, Vishal, Pras-Raves, Mia L., Drögemöller, Britt I., Grootemaat, Anita E., van der Wel, Nicole N., Dobritzsch, Doreen, Roseboom, Winfried, Schomakers, Bauke V., Jaspers, Yorrick R.J., Zoetekouw, Lida, Roelofsen, Jeroen, Ferreira, Carlos R., van der Lee, Robin, Ross, Colin J., Kochan, Jakub, McIntyre, Rebecca L., van Klinken, Jan B., van Weeghel, Michel, Kramer, Gertjan, Weschke, Bernhard, Labrune, Philippe, Willemsen, Michèl A., Riva, Daria, Garavaglia, Barbara, Moeschler, John B., Filiano, James J., Ekker, Marc, Berman, Jason N., Dyment, David, Vaz, Frédéric M., Wasserman, Wyeth W., Houtkooper, Riekelt H., van Kuilenburg, André B.P.

“…The functionality of many cellular proteins depends on cofactors; yet, they have only been implicated in a minority of Mendelian diseases. Here, we describe…”
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Akt and mTORC1 Have Different Roles During Liver Tumorigenesis in Mice by Kenerson, Heidi L, Yeh, Matthew M, Kazami, Machiko, Jiang, Xiuyun, Riehle, Kimberly J, McIntyre, Rebecca L, Park, James O, Kwon, Steve, Campbell, Jean S, Yeung, Raymond S

“…Background & Aims Phosphatidylinositide 3-kinase (PI3K) is deregulated in many human tumor types, including primary liver malignancies. The kinase v-akt murine…”
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Polybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency by McIntyre, Rebecca L, Kenerson, Heidi L, Subramanian, Savitha, Wang, Shari A, Kazami, Machiko, Stapleton, Heather M, Yeung, Raymond S

“…The potential health effects of polybrominated diphenyl ethers (PBDEs) that are widely used as flame-retardants in consumer products have been attributed, in…”
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CIAO1 and MMS19 de fi ciency: A lethal neurodegenerative phenotype caused by cytosolic Fe-S cluster protein assembly disorders by van Karnebeek, Clara D. M., Tarailo-Graovac, Maja, Leen, Rene, Meinsma, Rutger, Correard, Solenne, Jansen-Meijer, Judith, Prykhozhij, Sergey V., Pena, Izabella A., Ban, Kevin, Schock, Sarah, Saxena, Vishal, Pras-Raves, Mia L., Drogemoller, Britt I., Grootemaat, Anita E., van der Wel, Nicole N., Dobritzsch, Doreen, Roseboom, Winfried, Schomakers, Bauke V., Jaspers, Yorrick R. J., Zoetekouw, Lida, Roelofsen, Jeroen, Ferreira, Carlos R., van der Lee, Robin, Ross, Colin J., Kochan, Jakub, McIntyre, Rebecca L., van Klinken, Jan B., van Weeghel, Michel, Kramer, Gertjan, Weschke, Bernhard, Labrune, Philippe, Willemsen, Michel A., Riva, Daria, Garavaglia, Barbara, Moeschler, John B., Filiano, James J., Ekker, Marc, Berman, Jason N., Dyment, David, Vaz, Frederic M., Wassermann, Wyeth W., Houtkooper, Riekelt H., van Kuilenburg, Andre B. P.

“…Purpose: The functionality of many cellular proteins depends on cofactors; yet, they have only been implicated in a minority of Mendelian diseases. Here, we…”
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