Search Results - "McIntyre, K. W."

Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice by Labow, M, Shuster, D, Zetterstrom, M, Nunes, P, Terry, R, Cullinan, EB, Bartfai, T, Solorzano, C, Moldawer, LL, Chizzonite, R, McIntyre, KW

“…IL-1alpha and IL-1beta are potent inflammatory cytokines that contribute to a number of normal physiologic processes and to the development of a number of…”
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Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2 by Purandare, A V, McDevitt, T M, Wan, H, You, D, Penhallow, B, Han, X, Vuppugalla, R, Zhang, Y, Ruepp, S U, Trainor, G L, Lombardo, L, Pedicord, D, Gottardis, M M, Ross-Macdonald, P, de Silva, H, Hosbach, J, Emanuel, S L, Blat, Y, Fitzpatrick, E, Taylor, T L, McIntyre, K W, Michaud, E, Mulligan, C, Lee, F Y, Woolfson, A, Lasho, T L, Pardanani, A, Tefferi, A, Lorenzi, M V

“…We report the characterization of BMS-911543, a potent and selective small-molecule inhibitor of the Janus kinase (JAK) family member, JAK2. Functionally,…”
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Inhibition of interleukin 1 (IL-1) binding and bioactivity in vitro and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody by MCINTYRE, K. W, STEPAN, G. J, KOLINSKY, K. D, BENJAMIN, W. R, PLOCINSKI, J. M, KAFFKA, K. L, CAMPEN, C. A, CHIZZONITE, R. A, KILIAN, P. L

“…Recombinant human interleukin 1 receptor antagonist (IL-1ra) and 35F5, a neutralizing monoclonal antibody (mAb) to the type I mouse IL-1 receptor, were…”
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Differential effect of E-selectin antibodies on neutrophil rolling and recruitment to inflammatory sites by RAMOS, C. L, KUNKEL, E. J, LEY, K, LAWRENCE, M. B, JUNG, U, VESTWEBER, D, BOSSE, R, MCINTYRE, K. W, GILLOOLY, K. M, NORTON, C. R, WOLITZKY, B. A

“…The selectins are inducible adhesion molecules critically important for the inflammatory response. We investigate here the functional effects of three…”
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Enhancement of antibacterial resistance of neutropenic, bone marrow-suppressed mice by interleukin-1 alpha by MCINTYRE, K. W, UNOWSKY, J, DELORENZO, W, BENJAMIN, W

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Phosphodiesterase 7A-Deficient Mice Have Functional T Cells by Yang, Guchen, McIntyre, Kim W, Townsend, Robert M, Shen, Henry H, Pitts, William J, Dodd, John H, Nadler, Steven G, McKinnon, Murray, Watson, Andrew J

“…Phosphodiesterases (PDEs) are enzymes which hydrolyze the cyclic nucleotide second messengers, cAMP and cGMP. In leukocytes, PDEs are responsible for depletion…”
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5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase by Liu, Chunjian, Wrobleski, Stephen T, Lin, James, Ahmed, Gulzar, Metzger, Axel, Wityak, John, Gillooly, Kathleen M, Shuster, David J, McIntyre, Kim W, Pitt, Sidney, Shen, Ding Ren, Zhang, Rosemary F, Zhang, Hongjian, Doweyko, Arthur M, Diller, David, Henderson, Ian, Barrish, Joel C, Dodd, John H, Schieven, Gary L, Leftheris, Katerina

“…A novel class of 5-cyanopyrimidine-based inhibitors of p38α MAP kinase has been investigated. Analogues optimized through SAR iterations display low nanomolar…”
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IL-1 Receptor Accessory Protein Is an Essential Component of the IL-1 Receptor by Cullinan, Emily B, Kwee, Lia, Nunes, Perla, Shuster, David J, Ju, Grace, McIntyre, Kim W, Chizzonite, Richard A, Labow, Mark A

“…The recently described IL-1R accessory protein (IL-1R AcP) interacts with IL-1beta and the IL-1 type-IR (IL-1RI), but an essential requirement for IL-1R AcP in…”
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Blastogenesis of large granular lymphocytes in nonlymphoid organs by McIntyre, K W, Natuk, R J, Biron, C A, Kase, K, Greenberger, J, Welsh, R M

“…High numbers of large granular lymphocytes (LGL) accumulate in the livers and peritoneal cavities of mice during the course of viral infection. Accumulation of…”
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Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice by McIntyre, K W, Shuster, D J, Gillooly, K M, Warrier, R R, Connaughton, S E, Hall, L B, Arp, L H, Gately, M K, Magram, J

“…Collagen-induced arthritis (CIA) is an animal model for rheumatoid arthritis. The disease is elicited by immunization of genetically susceptible DBA/1 mice…”
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A highly selective inhibitor of IkB kinase, BMS-345541, augments graft survival mediated by suboptimal immunosuppression in a murine model of cardiac graft rejection by Townsend, R M, Postelnek, J, Susulic, V, McIntyre, K W, Shuster, D J, Qiu, Y, Zusi, F C, Burke, J R

“…Background. We previously demonstrated in vitro and in vivo that an IkB kinase (IKK) inhibitor blocks cytokine production and suppresses immune responses…”
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Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis by LETVIN, N. L, LINCH, D. C, BEARDSLEY, G. P, MCINTYRE, K. W, MILLER, B. A, NATHAN, D. G

“…To determine the influence of cell cycle-specific agents on primate hematopoiesis and fetal hemoglobin production, two juvenile cynomolgus monkeys (Macaca…”
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Natural Killer Cells Are Not Required for Interferon-mediated Prophylaxis Against Vaccinia or Murine Cytomegalovirus Infections by Bukowski, Jack F, McIntyre, Kim W, Yang, Hyekyung, Welsh, Raymond M

“…Department of Pathology, University of Massachusetts Medical Center, Worcester, Massachusetts 01605, U.S.A. Natural killer (NK) cell-depleted or control mice…”
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Interleukin 1 : an important mediator of host resistance against Pneumocystis carinii by WANGXUE CHEN, HAVELL, E. A, MOLDAWER, L. L, MCINTYRE, K. W, CHIZZONITE, R. A, HARMSEN, A. G

“…The importance of endogenous interleukin 1 (IL-1) in resistance to Pneumocystis carinii infection was examined in a SCID mouse model. Naturally acquired…”
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Enhanced antitumor efficacy in mice by combination treatment with interleukin-1 alpha and interferon-alpha by Brunda, M J, Wright, R B, Luistro, L, Harbison, M L, Anderson, T D, McIntyre, K W

“…The antitumor efficacy of recombinant murine interleukin-1 alpha (rMuIL-1 alpha) was evaluated either alone or in combination with recombinant human hybrid…”
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Synthesis and biological activity of novel C-terminal-extended and biotinylated growth hormone-releasing factor (GRF) analogs by Campbell, R M, Lee, Y, Mowles, T F, McIntyre, K W, Ahmad, M, Felix, A M, Heimer, E P

“…A series of novel hGRF(1-29)-NH2 analogs were synthesized and biotinylated. The immunological and biological activities of these analogs were then…”
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Accumulation of natural killer and cytotoxic T large granular lymphocytes in the liver during virus infection by MCINTYRE, K. W, WELSH, R. M

“…The immunologic mechanisms involved in virus-induced hepatitis were examined by measuring the cytotoxic capabilities and the morphologic and antigenic…”
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Exquisite specificity of adoptive immunization in arenavirus-infected mice by McIntyre, K W, Bukowski, J F, Welsh, R M

“…Lymphocytic choriomeningitis virus (LCMV)-infected mice can be adoptively immunized with T cells from immune mice sharing MHC compatibility in H-2K or D,…”
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Insertion of a structural domain of interleukin (IL)-1 beta confers agonist activity to the IL-1 receptor antagonist. Implications for IL-1 bioactivity by Greenfeder, S A, Varnell, T, Powers, G, Lombard-Gillooly, K, Shuster, D, McIntyre, K W, Ryan, D E, Levin, W, Madison, V, Ju, G

“…We showed previously that replacement of Lys-145 in the IL-1 receptor antagonist (IL-1ra) with Asp resulted in an analog (IL-1ra K145D) with partial agonist…”
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Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea by Letvin, N L, Linch, D C, Beardsley, G P, McIntyre, K W, Nathan, D G

“…The increase in fetal-hemoglobin synthesis in patients with beta-thalassemia or sickle-cell anemia induced by 5-azacytidine has been attributed to…”
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