Search Results - "McIntosh, Thomas J."

Water Permeability of Aquaporin-4 Channel Depends on Bilayer Composition, Thickness, and Elasticity by Tong, Jihong, Briggs, Margaret M., McIntosh, Thomas J.

“…Aquaporin-4 (AQP4) is the primary water channel in the mammalian brain, particularly abundant in astrocytes, whose plasma membranes normally contain high…”
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Functional lipids and lipoplexes for improved gene delivery by Zhang, Xiao-Xiang, McIntosh, Thomas J., Grinstaff, Mark W.

“…Cationic lipids are the most common non-viral vectors used in gene delivery with a few currently being investigated in clinical trials. However, like most…”
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Stepping between Membrane Microdomains by McIntosh, Thomas J.

“…Lateral membrane microdomains are postulated to be involved in a number of important functions in mammalian cells, such as membrane trafficking, exocytosis,…”
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The Water Permeability and Pore Entrance Structure of Aquaporin-4 Depend on Lipid Bilayer Thickness by Tong, Jihong, Wu, Zhe, Briggs, Margaret M., Schulten, Klaus, McIntosh, Thomas J.

“…Aquaporin-4 (AQP4), the primary water channel in glial cells of the mammalian brain, plays a critical role in water transport in the central nervous system…”
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Organization of Skin Stratum Corneum Extracellular Lamellae: Diffraction Evidence for Asymmetric Distribution of Cholesterol by McIntosh, Thomas J.

“…Lipid suspensions containing 2:1:1 skin ceramides:palmitic acid:cholesterol, similar to the lipid composition found in the extracellular matrix of skin stratum…”
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From Brittle to Pliant Viscoelastic Materials with Solid State Linear Polyphosphonium–Carboxylate Assemblies by Godeau, Guilhem, Navailles, Laurence, Nallet, Frédéric, Lin, Xinrong, McIntosh, Thomas J, Grinstaff, Mark W

“…A polystyrenylphosphonium polymer was synthesized and complexed with various carboxylic acid derivatives to form new solid-state polyelectrolyte–surfactant…”
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Role of GAP-43 in Sequestering Phosphatidylinositol 4,5-Bisphosphate to Raft Bilayers by Tong, Jihong, Nguyen, Lam, Vidal, Adriana, Simon, Sidney A., Skene, J.H. Pate, McIntosh, Thomas J.

“…The lipid phosphatidylinositol 4,5-bisphosphate (PIP 2) is critical for a number of physiological functions, and its presence in membrane microdomains (rafts)…”
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Influence of Lipid Composition on Physical Properties and PEG-Mediated Fusion of Curved and Uncurved Model Membrane Vesicles:  “Nature's Own” Fusogenic Lipid Bilayer by Haque, Md. Emdadul, McIntosh, Thomas J, Lentz, Barry R

“…Poly(ethylene glycol) (PEG)-mediated fusion of phosphatidylcholine model membranes has been shown to mimic the protein-mediated biomembrane process [Lee, J.,…”
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Lipopolysaccharide Bilayer Structure:  Effect of Chemotype, Core Mutations, Divalent Cations, and Temperature by Snyder, Scott, Kim, Dennis, McIntosh, Thomas J

“…Lipopolysaccharide (LPS), the primary lipid on the surface of Gram-negative bacteria, is thought to act as a protective and permeability barrier. X-ray…”
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Effects of Natural and Enantiomeric Cholesterol on the Thermotropic Phase Behavior and Structure of Egg Sphingomyelin Bilayer Membranes by Mannock, David A., McIntosh, Thomas J., Jiang, Xin, Covey, Douglas F., McElhaney, Ronald N.

“…Phospholipids, sphingolipids, and sterols are the major lipid components of the plasma membranes of eukaryotic cells. Because these three lipid classes occur…”
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The water permeability of lens aquaporin-0 depends on its lipid bilayer environment by Tong, Jihong, Canty, John T., Briggs, Margaret M., McIntosh, Thomas J.

“…Aquaporin-0 (AQP0), the primary water channel in lens fiber cells, is critical to lens development, organization, and function. In the avascular lens there is…”
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Identification of a Binding Motif in the S5 Helix That Confers Cholesterol Sensitivity to the TRPV1 Ion Channel by Picazo-Juárez, Giovanni, Romero-Suárez, Silvina, Nieto-Posadas, Andrés, Llorente, Itzel, Jara-Oseguera, Andrés, Briggs, Margaret, McIntosh, Thomas J., Simon, Sidney A., Ladrón-de-Guevara, Ernesto, Islas, León D., Rosenbaum, Tamara

“…The TRPV1 ion channel serves as an integrator of noxious stimuli with its activation linked to pain and neurogenic inflammation. Cholesterol, a major component…”
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Melittin-Induced Bilayer Leakage Depends on Lipid Material Properties: Evidence for Toroidal Pores by Allende, Daniel, Simon, S.A., McIntosh, Thomas J.

“…The membrane-lytic peptide melittin has previously been shown to form pores in lipid bilayers that have been described in terms of two different structural…”
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Charge-Reversal Lipids, Peptide-Based Lipids, and Nucleoside-Based Lipids for Gene Delivery by LaManna, Caroline M, Lusic, Hrvoje, Camplo, Michel, McIntosh, Thomas J, Barthélémy, Philippe, Grinstaff, Mark W

“…Twenty years after gene therapy was introduced in the clinic, advances in the technique continue to garner headlines as successes pique the interest of…”
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Effect of Bilayer Composition on the Phase Behavior of Liposomal Suspensions Containing Poly(ethylene glycol)-Lipids by Hristova, Kalina, Kenworthy, Anne, McIntosh, Thomas J

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Electrostatic Control of Phospholipid Polymorphism by Tarahovsky, Yury S., Arsenault, A. Larry, MacDonald, Robert C., McIntosh, Thomas J., Epand, Richard M.

“…A regular progression of polymorphic phase behavior was observed for mixtures of the anionic phospholipid, cardiolipin, and the cationic phospholipid…”
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Packing and viscoelasticity of polyunsaturated omega-3 and omega-6 lipid bilayers as seen by (2)H NMR and X-ray diffraction by Rajamoorthi, Kannan, Petrache, Horia I, McIntosh, Thomas J, Brown, Michael F

“…Polyunsaturated phospholipids of the omega-3 and omega-6 classes play key roles in cellular functions, yet their mechanisms of biological action are still a…”
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Sorting of Lens Aquaporins and Connexins into Raft and Nonraft Bilayers: Role of Protein Homo-Oligomerization by Tong, Jihong, Briggs, Margaret M., Mlaver, David, Vidal, Adriana, McIntosh, Thomas J.

“…Two classes of channel-forming proteins in the eye lens, the water channel aquaporin-0 (AQP-0) and the connexins Cx46 and Cx50, are preferentially located in…”
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Roles of bilayer material properties in function and distribution of membrane proteins by McIntosh, Thomas J, Simon, Sidney A

“…Structural, compositional, and material (elastic) properties of lipid bilayers exert strong influences on the interactions of water-soluble proteins and…”
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Synthesis, Characterization, and In Vitro Transfection Activity of Charge-Reversal Amphiphiles for DNA Delivery by Zhang, Xiao-Xiang, Prata, Carla A. H, Berlin, Jason A, McIntosh, Thomas J, Barthelemy, Philippe, Grinstaff, Mark W

“…A series of charge-reversal lipids were synthesized that possess varying chain lengths and end functionalities. These lipids were designed to bind and then…”
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