Search Results - "McIntosh, Martin W"

Neutrophils dominate the immune cell composition in non-small cell lung cancer by Kargl, Julia, Busch, Stephanie E., Yang, Grace H. Y., Kim, Kyoung-Hee, Hanke, Mark L., Metz, Heather E., Hubbard, Jesse J., Lee, Sylvia M., Madtes, David K., McIntosh, Martin W., Houghton, A. McGarry

“…The response rate to immune checkpoint inhibitor therapy for non-small-cell lung cancer (NSCLC) is just 20%. To improve this figure, several early phase…”
Get full text

A targeted proteomics-based pipeline for verification of biomarkers in plasma by Paulovich, Amanda G, Whiteaker, Jeffrey R, Lin, Chenwei, Kennedy, Jacob, Hou, Liming, Trute, Mary, Sokal, Izabela, Yan, Ping, Schoenherr, Regine M, Zhao, Lei, Voytovich, Uliana J, Kelly-Spratt, Karen S, Krasnoselsky, Alexei, Gafken, Philip R, Hogan, Jason M, Jones, Lisa A, Wang, Pei, Amon, Lynn, Chodosh, Lewis A, Nelson, Peter S, McIntosh, Martin W, Kemp, Christopher J

“…Prioritizing candidate biomarkers for verification remains a formidable obstacle to the translation of protein diagnostics to clinical applications. Whiteaker…”
Get full text

Mass Spectrometry Based Targeted Protein Quantification: Methods and Applications by Pan, Sheng, Aebersold, Ruedi, Chen, Ru, Rush, John, Goodlett, David R, McIntosh, Martin W, Zhang, Jing, Brentnall, Teresa A

“…The recent advance in technology for mass spectrometry-based targeted protein quantification has opened new avenues for a broad range of proteomic applications…”
Get full text

Statistical Inference from Multiple iTRAQ Experiments without Using Common Reference Standards by Herbrich, Shelley M, Cole, Robert N, West, Keith P, Schulze, Kerry, Yager, James D, Groopman, John D, Christian, Parul, Wu, Lee, O’Meally, Robert N, May, Damon H, McIntosh, Martin W, Ruczinski, Ingo

“…Isobaric tags for relative and absolute quantitation (iTRAQ) is a prominent mass spectrometry technology for protein identification and quantification that is…”
Get full text

Ovarian cancer biomarker performance in prostate, lung, colorectal, and ovarian cancer screening trial specimens by Cramer, Daniel W, Bast, Jr, Robert C, Berg, Christine D, Diamandis, Eleftherios P, Godwin, Andrew K, Hartge, Patricia, Lokshin, Anna E, Lu, Karen H, McIntosh, Martin W, Mor, Gil, Patriotis, Christos, Pinsky, Paul F, Thornquist, Mark D, Scholler, Nathalie, Skates, Steven J, Sluss, Patrick M, Srivastava, Sudhir, Ward, David C, Zhang, Zhen, Zhu, Claire S, Urban, Nicole

“…Establishing a cancer screening biomarker's intended performance requires "phase III" specimens obtained in asymptomatic individuals before clinical diagnosis…”
Get full text

Longitudinal Screening Algorithm That Incorporates Change Over Time in CA125 Levels Identifies Ovarian Cancer Earlier Than a Single-Threshold Rule by Drescher, Charles W, Shah, Chirag, Thorpe, Jason, O'Briant, Kathy, Anderson, Garnet L, Berg, Christine D, Urban, Nicole, McIntosh, Martin W

“…Longitudinal algorithms incorporate change over time in biomarker levels to individualize screening decision rules. Compared with a single-threshold (ST) rule,…”
Get full text

Phenotypic and transcriptional fidelity of patient-derived colon cancer xenografts in immune-deficient mice by Chou, Jeffrey, Fitzgibbon, Matthew P, Mortales, Christie-Lynn L, Towlerton, Andrea M H, Upton, Melissa P, Yeung, Raymond S, McIntosh, Martin W, Warren, Edus H

“…Xenografts of human colorectal cancer (CRC) in immune-deficient mice have great potential for accelerating the study of tumor biology and therapy. We evaluated…”
Get full text

Integrated Pipeline for Mass Spectrometry-Based Discovery and Confirmation of Biomarkers Demonstrated in a Mouse Model of Breast Cancer by Whiteaker, Jeffrey R, Zhang, Heidi, Zhao, Lei, Wang, Pei, Kelly-Spratt, Karen S, Ivey, Richard G, Piening, Brian D, Feng, Li-Chia, Kasarda, Erik, Gurley, Kay E, Eng, Jimmy K, Chodosh, Lewis A, Kemp, Christopher J, McIntosh, Martin W, Paulovich, Amanda G

“…Despite their potential to impact diagnosis and treatment of cancer, few protein biomarkers are in clinical use. Biomarker discovery is plagued with…”
Get full text

Proteomics portrait of archival lesions of chronic pancreatitis by Pan, Sheng, Chen, Ru, Stevens, Tyler, Bronner, Mary P, May, Damon, Tamura, Yasuko, McIntosh, Martin W, Brentnall, Teresa A

“…Chronic pancreatitis is a chronic inflammatory disorder of the pancreas. The etiology is multi-fold, but all lead to progressive scarring and loss of…”
Get full text

Combining Several Screening Tests: Optimality of the Risk Score by McIntosh, Martin W., Pepe, Margaret Sullivan

“…The development of biomarkers for cancer screening is an active area of research. While several biomarkers exist, none is sufficiently sensitive and specific…”
Get full text

Influence of Ovarian Cancer Risk Status on the Diagnostic Performance of the Serum Biomarkers Mesothelin, HE4, and CA125 by Shah, Chirag A, Lowe, Kimberly A, Paley, Pamela, Wallace, Erin, Anderson, Garnet L, McIntosh, Martin W, Andersen, M Robyn, Scholler, Nathalie, Bergan, Lindsay A, Thorpe, Jason D, Urban, Nicole, Drescher, Charles W

“…Objective: To evaluate the effect of ovarian cancer risk on the performance of the serum biomarkers mesothelin, human epididymis protein 4 (HE4), and CA125…”
Get full text

Proteomic analysis of ovarian cancer cells reveals dynamic processes of protein secretion and shedding of extra-cellular domains by Faça, Vitor M, Ventura, Aviva P, Fitzgibbon, Mathew P, Pereira-Faça, Sandra R, Pitteri, Sharon J, Green, Ann E, Ireton, Renee C, Zhang, Qing, Wang, Hong, O'Briant, Kathy C, Drescher, Charles W, Schummer, Michèl, McIntosh, Martin W, Knudsen, Beatrice S, Hanash, Samir M

“…Elucidation of the repertoire of secreted and cell surface proteins of tumor cells is relevant to molecular diagnostics, tumor imaging and targeted therapies…”
Get full text

Evaluation of the novel serum markers B7-H4, Spondin 2, and DcR3 for diagnosis and early detection of ovarian cancer by Simon, Iris, Liu, Yan, Krall, Kirstin L, Urban, Nicole, Wolfert, Robert L, Kim, Nam W, McIntosh, Martin W

“…Abstract Objective Early detection through regular screening could significantly reduce mortality from ovarian cancer. Advances in biomarkers and imaging…”
Get full text

Antibody Immunity to the p53 Oncogenic Protein Is a Prognostic Indicator in Ovarian Cancer by GOODELL, Vivian, SALAZAR, Lupe G, URBAN, Nicole, DRESCHER, Charles W, GRAY, Heidi, SWENSEN, Ron E, MCLNTOSH, Martin W, DISIS, Mary L

“…Presence of intratumoral T-cell infiltration has been linked to improved survival in ovarian cancer patients. We questioned whether antibody immunity specific…”
Get full text

Modification of Host Lipid Raft Proteome upon Hepatitis C Virus Replication by Mannová, Petra, Fang, Ruihua, Wang, Hong, Deng, Bin, McIntosh, Martin W, Hanash, Samir M, Beretta, Laura

“…Hepatitis C virus (HCV) replication complex resides in detergent-insoluble subcellular domains or lipid rafts. We used two proteomics approaches to…”
Get full text

Systematic evaluation of candidate blood markers for detecting ovarian cancer by Palmer, Chana, Duan, Xiaobo, Hawley, Sarah, Scholler, Nathalie, Thorpe, Jason D, Sahota, Rob A, Wong, May Q, Wray, Andrew, Bergan, Lindsay A, Drescher, Charles W, McIntosh, Martin W, Brown, Patrick O, Nelson, Brad H, Urban, Nicole

“…Epithelial ovarian cancer is a significant cause of mortality both in the United States and worldwide, due largely to the high proportion of cases that present…”
Get full text

Brain-specific Proteins Decline in the Cerebrospinal Fluid of Humans with Huntington Disease by Fang, Qiaojun, Strand, Andrew, Law, Wendy, Faca, Vitor M., Fitzgibbon, Matthew P., Hamel, Nathalie, Houle, Benoit, Liu, Xin, May, Damon H., Poschmann, Gereon, Roy, Line, Stuühler, Kai, Ying, Wantao, Zhang, Jiyang, Zheng, Zhaobin, Bergeron, John J.M., Hanash, Sam, He, Fuchu, Leavitt, Blair R., Meyer, Helmut E., Qian, Xiaohong, McIntosh, Martin W.

“…We integrated five sets of proteomics data profiling the constituents of cerebrospinal fluid (CSF) derived from Huntington disease (HD)-affected and…”
Get full text

Detection of Elevated Plasma Levels of Epidermal Growth Factor Receptor Before Breast Cancer Diagnosis among Hormone Therapy Users by PITTERI, Sharon J, AMON, Lynn M, LAMPE, Paul D, PRENTICE, Ross L, MCLNTOSH, Martin W, HANASH, Samir M, LI, Christopher I, BUSALD BUSON, Tina, YUZHENG ZHANG, JOHNSON, Melissa M, CHIN, Alice, KENNEDY, Jacob, WONG, Chee-Hong, QING ZHANG, HONG WANG

“…Applying advanced proteomic technologies to prospectively collected specimens from large studies is one means of identifying preclinical changes in plasma…”
Get full text

Impact of protein stability, cellular localization, and abundance on proteomic detection of tumor-derived proteins in plasma by Fang, Qiaojun, Kani, Kian, Faca, Vitor M, Zhang, Wenxuan, Zhang, Qing, Jain, Anjali, Hanash, Sam, Agus, David B, McIntosh, Martin W, Mallick, Parag

“…Tumor-derived, circulating proteins are potentially useful as biomarkers for detection of cancer, for monitoring of disease progression, regression and…”
Get full text

Quantitative proteomics investigation of pancreatic intraepithelial neoplasia by Pan, Sheng, Chen, Ru, Reimel, Beth Ann, Crispin, David A, Mirzaei, Hamid, Cooke, Kelly, Coleman, Joshua F, Lane, Zhaoli, Bronner, Mary P, Goodlett, David R, McIntosh, Martin W, Traverso, William, Aebersold, Ruedi, Brentnall, Teresa A

“…Patients with pancreatic cancer are usually diagnosed at late stages, when the disease is incurable. Pancreatic intraepithelial neoplasia (PanIN) 3 is believed…”
Get full text