Search Results - "McIntosh, JK"

An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth by LIANG YOU, BIAO HE, MCCORMICK, Frank, JABLONS, David M, ZHIDONG XU, UEMATSU, Kazutsugu, MAZIERES, Julien, FUJII, Naoaki, MIKAMI, Iwao, REGUART, Noemi, MCINTOSH, Joe K, KASHANI-SABET, Mohammed

“…Activation of the Wnt/beta-catenin signaling pathway has been associated with human cancers. To test whether Wnt-2 signal is a survival factor in human…”
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Expansion of Myeloid Suppressor Cells in SHIP-Deficient Mice Represses Allogeneic T Cell Responses by Ghansah, Tomar, Paraiso, Kim H. T, Highfill, Steven, Desponts, Caroline, May, Sarah, McIntosh, Joseph K, Wang, Jia-Wang, Ninos, John, Brayer, Jason, Cheng, Fengdong, Sotomayor, Eduardo, Kerr, William G

“…Previously we demonstrated that SHIP(-/-) mice accept allogeneic bone marrow transplants (BMT) without significant acute graft-vs-host disease (GvHD). In this…”
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Antitumor activity of recombinant interleukin 6 in mice by MULE, J. J, MCINTOSH, J. K, JABLONS, D. M, ROSENBERG, S. A

“…IL-6 possesses multiple biologic activities that affect a broad range of cells including those directly involved in immune responses as well as cells important…”
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IL-6/IFN-beta-2 as a circulating hormone. Induction by cytokine administration in humans by Jablons, DM, Mule, JJ, McIntosh, JK, Sehgal, PB, May, LT, Huang, CM, Rosenberg, SA, Lotze, MT

“…IL-6/IFN-beta 2 is a family of phosphoglycoproteins ranging in size from 19 to 30 kDa which elicits a broad range of physiologic and immune responses. Several…”
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Synergistic antitumor effects of combination immunotherapy with recombinant interleukin-2 and a recombinant hybrid α-interferon in the treatment of established murine hepatic metastases by CAMERON, R. B, MCINTOSH, J. K, ROSENBERG, S. A

“…We investigated the antitumor effects of combined immunotherapy with recombinant human interleukin-2 (rhIL-2) and the recombinant human interferon-alpha…”
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In vivo induction of IL-6 by administration of exogenous cytokines and detection of de novo serum levels of IL-6 in tumor-bearing mice by McIntosh, JK, Jablons, DM, Mule, JJ, Nordan, RP, Rudikoff, S, Lotze, MT, Rosenberg, SA

“…We investigated the capacity of several recombinant cytokines to induce IL-6 in vivo in both normal and tumor-bearing (TB) mice. Intravenous administration of…”
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Synergistic antitumor effects of immunotherapy with recombinant interleukin-2 and recombinant tumor necrosis factor-α by MCINTOSH, J. K, MULE, J. J, MERINO, M. J, ROSENBERG, S. A

“…The antitumor activity of combination therapy with recombinant tumor necrosis-alpha (rhTNF-alpha) and recombinant interleukin-2 (rhIL-2) was assessed against…”
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Combination cytokine immunotherapy with tumor necrosis factor α, interleukin 2, and α-interferon and its synergistic antitumor effects in mice by MCINTOSH, J. K, MULE, J. J, KROSNICK, J. A, ROSENBERG, S. A

“…The antitumor activity of combination therapy with recombinant human tumor necrosis factor alpha (rhTNF-alpha), recombinant human interleukin 2 (rhIL-2), and…”
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Nutritional management of acute and chronic pancreatitis by Latifi, R, McIntosh, J K, Dudrick, S J

“…Acute pancreatitis often results in a catabolic state characterized by profound hemodynamic, metabolic, cardiovascular, pulmonary, hematologic, and renal…”
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Manipulation of oxygen radical-scavenging capacity in mice alters host sensitivity to tumor necrosis factor toxicity but does not interfere with its antitumor efficacy by HAUSER, G. J, MCINTOSH, J. K, TRAVIS, W. D, ROSENBERG, S. A

“…The role of oxygen free radicals in the toxicity and antitumor effect of tumor necrosis factor was investigated in vivo. Treatment of non-tumor-bearing mice…”
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Studies of effects of recombinant human tumor necrosis factor on autochthonous tumor and transplanted normal tissue in mice by MCINTOSH, J. K, MULE, J. J, TRAVIS, W. D, ROSENBERG, S. A

“…The acute hemorrhagic necrosis of tumor nodules caused by the systemic administration of recombinant human tumor necrosis factor alpha (rhTNF-alpha) has been…”
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Effect of recombinant human tumor necrosis factor α on the induction of antibody-dependent cellular cytotoxicity in the treatment of established B16 melanoma liver nodules by EISENTHAL, A, MCINTOSH, J. K

“…Incubation of C3H/Hen thymocytes in the presence of recombinant human tumor necrosis factor alpha (TNF) and interleukin-2 (IL-2) augmented the generation of…”
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Induction of interferon-beta 2/interleukin-6 (IL-6) by cytokine administration and detection of circulating interleukin-6 in the tumor-bearing state by Jablons, D M, McIntosh, J K, Mulé, J J, Nordan, R P, Rudikoff, S, Lotze, M T

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Studies of the mechanisms of toxicity of the administration of recombinant tumor necrosis factor α in normal and tumor-bearing mice by KROSNICK, J. A, MCINTOSH, J. K, MULE, J. J, ROSENBERG, S. A

“…Tumor-bearing mice have a greater sensitivity to the acute lethal effects of the administration of high-dose recombinant human tumor necrosis factor alpha…”
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