Search Results - "McIntosh, J Richard"

Regulation of microtubule dynamics, mechanics and function through the growing tip by Gudimchuk, Nikita B., McIntosh, J. Richard

“…Microtubule dynamics and their control are essential for the normal function and division of all eukaryotic cells. This plethora of functions is, in large…”
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Mitosis by McIntosh, J Richard

“…SUMMARYAll eukaryotic cells prepare for cell division by forming a "mitotic spindle"-a bipolar machine made from microtubules (MTs) and many associated…”
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Microtubules grow by the addition of bent guanosine triphosphate tubulin to the tips of curved protofilaments by McIntosh, J Richard, O'Toole, Eileen, Morgan, Garry, Austin, Jotham, Ulyanov, Evgeniy, Ataullakhanov, Fazoil, Gudimchuk, Nikita

“…We used electron tomography to examine microtubules (MTs) growing from pure tubulin in vitro as well as two classes of MTs growing in cells from six species…”
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Electron tomography reveals aspects of spindle structure important for mechanical stability at metaphase by O'Toole, Eileen, Morphew, Mary, McIntosh, J Richard

“…Metaphase spindles exert pole-directed forces on still-connected sister kinetochores. The spindle must counter these forces with extensive forces to prevent…”
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Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography by Gudimchuk, Nikita B., Ulyanov, Evgeni V., O’Toole, Eileen, Page, Cynthia L., Vinogradov, Dmitrii S., Morgan, Garry, Li, Gabriella, Moore, Jeffrey K., Szczesna, Ewa, Roll-Mecak, Antonina, Ataullakhanov, Fazoil I., Richard McIntosh, J.

“…Microtubules are dynamic tubulin polymers responsible for many cellular processes, including the capture and segregation of chromosomes during mitosis. In…”
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Arrangement of Photosystem II and ATP Synthase in Chloroplast Membranes of Spinach and Pea by Daum, Bertram, Nicastro, Daniela, Austin, Jotham II, McIntosh, J. Richard, Kühlbrandt, Werner

“…We used cryoelectron tomography to reveal the arrangements of photosystem II (PSII) and ATP synthase in vitreous sections of intact chloroplasts and…”
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Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling by Edelmaier, Christopher, Lamson, Adam R, Gergely, Zachary R, Ansari, Saad, Blackwell, Robert, McIntosh, J Richard, Glaser, Matthew A, Betterton, Meredith D

“…The essential functions required for mitotic spindle assembly and chromosome biorientation and segregation are not fully understood, despite extensive study…”
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Molecular Architecture of Axonemes Revealed by Cryoelectron Tomography by Nicastro, Daniela, Schwartz, Cindi, Pierson, Jason, Gaudette, Richard, Porter, Mary E, McIntosh, J. Richard

“…Eukaryotic flagella and cilia are built on a 9 + 2 array of microtubules plus >250 accessory proteins, forming a biological machine called the axoneme. Here we…”
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Brownian dynamics simulation of protofilament relaxation during rapid freezing by Ulyanov, Evgeniy V, Vinogradov, Dmitrii S, McIntosh, J Richard, Gudimchuk, Nikita B

“…Electron cryo-microscopy (Cryo-EM) is a powerful method for visualizing biological objects with up to near-angstrom resolution. Instead of chemical fixation,…”
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Ultrastructural Analysis of Microtubule Ends by Richard McIntosh, J, O'Toole, Eileen, Page, Cynthia, Morgan, Garry

“…Microtubules can be detected in light microscopes, but the limited resolution of these instruments means that the polymers appear as lines whose width is…”
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Augmin-dependent microtubule nucleation at microtubule walls in the spindle by Kamasaki, Tomoko, O'Toole, Eileen, Kita, Shigeo, Osumi, Masako, Usukura, Jiro, McIntosh, J Richard, Goshima, Gohta

“…The formation of a functional spindle requires microtubule (MT) nucleation from within the spindle, which depends on augmin. How augmin contributes to MT…”
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Kinesin-8 effects on mitotic microtubule dynamics contribute to spindle function in fission yeast by Gergely, Zachary R, Crapo, Ammon, Hough, Loren E, McIntosh, J Richard, Betterton, Meredith D

“…Kinesin-8 motor proteins destabilize microtubules. Their absence during cell division is associated with disorganized mitotic chromosome movements and…”
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Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes by Link, Fabian, Borges, Alyssa, Karo, Oliver, Jungblut, Marvin, Müller, Thomas, Meyer-Natus, Elisabeth, Krüger, Timothy, Sachs, Stefan, Jones, Nicola G, Morphew, Mary, Sauer, Markus, Stigloher, Christian, McIntosh, J Richard, Engstler, Markus

“…Endocytosis is a common process observed in most eukaryotic cells, although its complexity varies among different organisms. In , the endocytic machinery is…”
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Conserved and divergent features of kinetochores and spindle microtubule ends from five species by McIntosh, J Richard, O'Toole, Eileen, Zhudenkov, Kirill, Morphew, Mary, Schwartz, Cindi, Ataullakhanov, Fazly I, Grishchuk, Ekaterina L

“…Interfaces between spindle microtubules and kinetochores were examined in diverse species by electron tomography and image analysis. Overall structures were…”
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Correction: Brownian dynamics simulation of protofilament relaxation during rapid freezing by Ulyanov, Evgeniy V, Vinogradov, Dmitrii S, McIntosh, J. Richard, Gudimchuk, Nikita B

“…[This corrects the article DOI: 10.1371/journal.pone.0247022.]…”
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CD4+ T-cell synapses involve multiple distinct stages by Ueda, Hironori, Morphew, Mary K, McIntosh, J. Richard, Davis, Mark M

“…One very striking feature of T-cell recognition is the formation of an immunological synapse between a T cell and a cell that it is recognizing. Formation of…”
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Biophysics of mitosis by McIntosh, J Richard, Molodtsov, Maxim I, Ataullakhanov, Fazly I

“…Mitosis is the process by which eukaryotic cells organize and segregate their chromosomes in preparation for cell division. It is accomplished by a cellular…”
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Probing the macromolecular organization of cells by electron tomography by Hoenger, Andreas, McIntosh, J Richard

“…A major goal in cell biology is to understand the functional organization of macromolecular complexes in vivo . Electron microscopy is helping cell biologists…”
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A Brief History of Research on Mitotic Mechanisms by McIntosh, J Richard, Hays, Thomas

“…This chapter describes in summary form some of the most important research on chromosome segregation, from the discovery and naming of mitosis in the…”
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Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography by Lacomble, Sylvain, Vaughan, Sue, Gadelha, Catarina, Morphew, Mary K, Shaw, Michael K, McIntosh, J. Richard, Gull, Keith

“…This study uses electron tomography linked to a variety of other EM methods to provide an integrated view of the flagellar pocket and basal body area of the…”
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