Search Results - "McIntosh, Fraser"

The M1/M4 preferring agonist xanomeline is analgesic in rodent models of chronic inflammatory and neuropathic pain via central site of action by Martino, Giovanni, Puma, Carole, Yu, Xiao Hong, Gilbert, Annie-Kim, Coupal, Martin, Markoglou, Nektaria, McIntosh, Fraser S., Perkins, Martin N., Laird, Jennifer M.A.

“…The data presented show that the nonselective muscarinic agonist xanomeline is analgesic in models of persistent pain and suggest that the activation of…”
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Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose Predictions by Caniga, Michael, Cabal, Antonio, Mehta, Khamir, Ross, David S, Gil, Malgorzata A, Woodhouse, Janice D, Eckman, Joseph, Naber, John R, Callahan, Marissa K, Goncalves, Luciano, Hill, Susan E, Mcleod, Robbie L, McIntosh, Fraser, Freke, Mark C, Visser, Sandra A G, Johnson, Neil, Salmon, Michael, Cicmil, Milenko

“…Understanding the relationship between dose, lung exposure, and drug efficacy continues to be a challenging aspect of inhaled drug development. An experimental…”
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Blocking Spinal CCR2 with AZ889 Reversed Hyperalgesia in a Model of Neuropathic Pain by Serrano, Alexandre, Paré, Michel, McIntosh, Fraser, Elmes, Steven JR, Martino, Giovanni, Jomphe, Claudia, Lessard, Etienne, Lembo, Paola MC, Vaillancourt, François, Perkins, Martin N, Cao, Chang Qing

“…Background: The CCR2/CCL2 system has been identified as a regulator in the pathogenesis of neuropathy-induced pain. However, CCR2 target validation in…”
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Selective Urokinase-Type Plasminogen Activator Inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines by Fish, Paul V, Barber, Christopher G, Brown, David G, Butt, Richard, Collis, Michael G, Dickinson, Roger P, Henry, Brian T, Horne, Valerie A, Huggins, John P, King, Elizabeth, O'Gara, Margaret, McCleverty, Dawn, McIntosh, Fraser, Phillips, Christopher, Webster, Robert

“…1-Isoquinolinylguanidines were previously disclosed as potent and selective inhibitors of urokinase-type plasminogen activator (uPA). Further investigation of…”
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Pesticides—A Review of Their Control, Safety and Forensic Interests by McIntosh, A. Fraser

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