Search Results - "McIntosh, Andrew M."

Uncovering the Genetic Architecture of Major Depression by McIntosh, Andrew M., Sullivan, Patrick F., Lewis, Cathryn M.

“…There have been several recent studies addressing the genetic architecture of depression. This review serves to take stock of what is known now about the…”
Get full text

Mental health before and during the COVID-19 pandemic in two longitudinal UK population cohorts by Kwong, Alex S. F., Pearson, Rebecca M., Adams, Mark J., Northstone, Kate, Tilling, Kate, Smith, Daniel, Fawns-Ritchie, Chloe, Bould, Helen, Warne, Naomi, Zammit, Stanley, Gunnell, David J., Moran, Paul A., Micali, Nadia, Reichenberg, Abraham, Hickman, Matthew, Rai, Dheeraj, Haworth, Simon, Campbell, Archie, Altschul, Drew, Flaig, Robin, McIntosh, Andrew M., Lawlor, Deborah A., Porteous, David, Timpson, Nicholas J.

“…The COVID-19 pandemic and mitigation measures are likely to have a marked effect on mental health. It is important to use longitudinal data to improve…”
Get full text

Genome-wide association study of multisite chronic pain in UK Biobank by Johnston, Keira J A, Adams, Mark J, Nicholl, Barbara I, Ward, Joey, Strawbridge, Rona J, Ferguson, Amy, McIntosh, Andrew M, Bailey, Mark E S, Smith, Daniel J

“…Chronic pain is highly prevalent worldwide and represents a significant socioeconomic and public health burden. Several aspects of chronic pain, for example…”
Get full text

Sex Differences in the Adult Human Brain: Evidence from 5216 UK Biobank Participants by Ritchie, Stuart J, Cox, Simon R, Shen, Xueyi, Lombardo, Michael V, Reus, Lianne M, Alloza, Clara, Harris, Mathew A, Alderson, Helen L, Hunter, Stuart, Neilson, Emma, Liewald, David C M, Auyeung, Bonnie, Whalley, Heather C, Lawrie, Stephen M, Gale, Catharine R, Bastin, Mark E, McIntosh, Andrew M, Deary, Ian J

“…Abstract Sex differences in the human brain are of interest for many reasons: for example, there are sex differences in the observed prevalence of psychiatric…”
Get full text

Cognitive Test Scores in UK Biobank: Data Reduction in 480,416 Participants and Longitudinal Stability in 20,346 Participants by Lyall, Donald M, Cullen, Breda, Allerhand, Mike, Smith, Daniel J, Mackay, Daniel, Evans, Jonathan, Anderson, Jana, Fawns-Ritchie, Chloe, McIntosh, Andrew M, Deary, Ian J, Pell, Jill P

“…UK Biobank includes 502,649 middle- and older-aged adults from the general population who have undergone detailed phenotypic assessment. The majority of…”
Get full text

Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts by Sanchez-Roige, Sandra, Palmer, Abraham A, Fontanillas, Pierre, Elson, Sarah L, Adams, Mark J, Howard, David M, Edenberg, Howard J, Davies, Gail, Crist, Richard C, Deary, Ian J, McIntosh, Andrew M, Clarke, Toni-Kim

“…Objective:Alcohol use disorders are common conditions that have enormous social and economic consequences. Genome-wide association analyses were performed to…”
Get full text

Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism by Luciano, Michelle, Hagenaars, Saskia P., Davies, Gail, Hill, W. David, Clarke, Toni-Kim, Shirali, Masoud, Harris, Sarah E., Marioni, Riccardo E., Liewald, David C., Fawns-Ritchie, Chloe, Adams, Mark J., Howard, David M., Lewis, Cathryn M., Gale, Catharine R., McIntosh, Andrew M., Deary, Ian J.

“…Neuroticism is a relatively stable personality trait characterized by negative emotionality (for example, worry and guilt) 1 ; heritability estimated from twin…”
Get full text

Associations between vascular risk factors and brain MRI indices in UK Biobank by Cox, Simon R, Lyall, Donald M, Ritchie, Stuart J, Bastin, Mark E, Harris, Mathew A, Buchanan, Colin R, Fawns-Ritchie, Chloe, Barbu, Miruna C, de Nooij, Laura, Reus, Lianne M, Alloza, Clara, Shen, Xueyi, Neilson, Emma, Alderson, Helen L, Hunter, Stuart, Liewald, David C, Whalley, Heather C, McIntosh, Andrew M, Lawrie, Stephen M, Pell, Jill P, Tucker-Drob, Elliot M, Wardlaw, Joanna M, Gale, Catharine R, Deary, Ian J

“…Abstract Aims Several factors are known to increase risk for cerebrovascular disease and dementia, but there is limited evidence on associations between…”
Get full text

Molecular Genetic Contributions to Social Deprivation and Household Income in UK Biobank by Hill, W. David, Hagenaars, Saskia P., Marioni, Riccardo E., Harris, Sarah E., Liewald, David C.M., Davies, Gail, Okbay, Aysu, McIntosh, Andrew M., Gale, Catharine R., Deary, Ian J.

“…Individuals with lower socio-economic status (SES) are at increased risk of physical and mental illnesses and tend to die at an earlier age [1–3]. Explanations…”
Get full text

Genomic analysis of family data reveals additional genetic effects on intelligence and personality by Hill, W. David, Arslan, Ruben C., Xia, Charley, Luciano, Michelle, Amador, Carmen, Navarro, Pau, Hayward, Caroline, Nagy, Reka, Porteous, David J., McIntosh, Andrew M., Deary, Ian J., Haley, Chris S., Penke, Lars

“…Pedigree-based analyses of intelligence have reported that genetic differences account for 50–80% of the phenotypic variation. For personality traits these…”
Get full text

Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income by Hill, W. David, Davies, Neil M., Ritchie, Stuart J., Skene, Nathan G., Bryois, Julien, Bell, Steven, Di Angelantonio, Emanuele, Roberts, David J., Xueyi, Shen, Davies, Gail, Liewald, David C. M., Porteous, David J., Hayward, Caroline, Butterworth, Adam S., McIntosh, Andrew M., Gale, Catharine R., Deary, Ian J.

“…Socioeconomic position (SEP) is a multi-dimensional construct reflecting (and influencing) multiple socio-cultural, physical, and environmental factors. In a…”
Get full text

Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank by Johnston, Keira J A, Ward, Joey, Ray, Pradipta R, Adams, Mark J, McIntosh, Andrew M, Smith, Blair H, Strawbridge, Rona J, Price, Theodore J, Smith, Daniel J, Nicholl, Barbara I, Bailey, Mark E S

“…Chronic pain is highly prevalent worldwide and imparts a significant socioeconomic and public health burden. Factors influencing susceptibility to, and…”
Get full text

Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing by Zhang, Qian, Vallerga, Costanza L, Walker, Rosie M, Lin, Tian, Henders, Anjali K, Montgomery, Grant W, He, Ji, Fan, Dongsheng, Fowdar, Javed, Kennedy, Martin, Pitcher, Toni, Pearson, John, Halliday, Glenda, Kwok, John B, Hickie, Ian, Lewis, Simon, Anderson, Tim, Silburn, Peter A, Mellick, George D, Harris, Sarah E, Redmond, Paul, Murray, Alison D, Porteous, David J, Haley, Christopher S, Evans, Kathryn L, McIntosh, Andrew M, Yang, Jian, Gratten, Jacob, Marioni, Riccardo E, Wray, Naomi R, Deary, Ian J, McRae, Allan F, Visscher, Peter M

“…DNA methylation changes with age. Chronological age predictors built from DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from…”
Get full text

Epigenetic prediction of complex traits and death by McCartney, Daniel L, Hillary, Robert F, Stevenson, Anna J, Ritchie, Stuart J, Walker, Rosie M, Zhang, Qian, Morris, Stewart W, Bermingham, Mairead L, Campbell, Archie, Murray, Alison D, Whalley, Heather C, Gale, Catharine R, Porteous, David J, Haley, Chris S, McRae, Allan F, Wray, Naomi R, Visscher, Peter M, McIntosh, Andrew M, Evans, Kathryn L, Deary, Ian J, Marioni, Riccardo E

“…Genome-wide DNA methylation (DNAm) profiling has allowed for the development of molecular predictors for a multitude of traits and diseases. Such predictors…”
Get full text

Self-reported medication use validated through record linkage to national prescribing data by Hafferty, Jonathan D., Campbell, Archie I., Navrady, Lauren B., Adams, Mark J., MacIntyre, Donald, Lawrie, Stephen M., Nicodemus, Kristin, Porteous, David J., McIntosh, Andrew M.

“…Researchers need to be confident about the reliability of epidemiologic studies that quantify medication use through self-report. Some evidence suggests that…”
Get full text

An epigenetic predictor of death captures multi-modal measures of brain health by Hillary, Robert F., Stevenson, Anna J., Cox, Simon R., McCartney, Daniel L., Harris, Sarah E., Seeboth, Anne, Higham, Jon, Sproul, Duncan, Taylor, Adele M., Redmond, Paul, Corley, Janie, Pattie, Alison, Hernández, Maria del. C. Valdés, Muñoz-Maniega, Susana, Bastin, Mark E., Wardlaw, Joanna M., Horvath, Steve, Ritchie, Craig W., Spires-Jones, Tara L., McIntosh, Andrew M., Evans, Kathryn L., Deary, Ian J., Marioni, Riccardo E.

“…Individuals of the same chronological age exhibit disparate rates of biological ageing. Consequently, a number of methodologies have been proposed to determine…”
Get full text

Identification of polymorphic and off-target probe binding sites on the Illumina Infinium MethylationEPIC BeadChip by McCartney, Daniel L., Walker, Rosie M., Morris, Stewart W., McIntosh, Andrew M., Porteous, David J., Evans, Kathryn L.

“…Genome-wide analysis of DNA methylation has now become a relatively inexpensive technique thanks to array-based methylation profiling technologies. The…”
Get full text

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data by Shen, Xueyi, Reus, Lianne M., Cox, Simon R., Adams, Mark J., Liewald, David C., Bastin, Mark E., Smith, Daniel J., Deary, Ian J., Whalley, Heather C., McIntosh, Andrew M.

“…Previous reports of altered grey and white matter structure in Major Depressive Disorder (MDD) have been inconsistent. Recent meta-analyses have, however,…”
Get full text

Blunted medial prefrontal cortico-limbic reward-related effective connectivity and depression by Rupprechter, Samuel, Romaniuk, Liana, Series, Peggy, Hirose, Yoriko, Hawkins, Emma, Sandu, Anca-Larisa, Waiter, Gordon D, McNeil, Christopher J, Shen, Xueyi, Harris, Mathew A, Campbell, Archie, Porteous, David, Macfarlane, Jennifer A, Lawrie, Stephen M, Murray, Alison D, Delgado, Mauricio R, McIntosh, Andrew M, Whalley, Heather C, Steele, J Douglas

“…Major depressive disorder is a leading cause of disability and significant mortality, yet mechanistic understanding remains limited. Over the past decade…”
Get full text

Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS) by Fernandez-Pujals, Ana Maria, Adams, Mark James, Thomson, Pippa, McKechanie, Andrew G, Blackwood, Douglas H R, Smith, Blair H, Dominiczak, Anna F, Morris, Andrew D, Matthews, Keith, Campbell, Archie, Linksted, Pamela, Haley, Chris S, Deary, Ian J, Porteous, David J, MacIntyre, Donald J, McIntosh, Andrew M

“…The heritability of Major Depressive Disorder (MDD) has been estimated at 37% based largely on twin studies that rely on contested assumptions. More recently,…”
Get full text