Search Results - "McIntee, J"

Pronucleotides: Toward the in vivo delivery of antiviral and anticancer nucleotides by Wagner, Carston R., Iyer, Vidhya V., McIntee, Edward J.

“…To overcome the many hurdles preventing the use of antiviral and anticancer nucleosides as therapeutics, the development of a prodrug methodology (i.e.,…”
Get full text

Identification of DNA Adducts of Acetaldehyde by Wang, Mingyao, McIntee, Edward J, Cheng, Guang, Shi, Yongli, Villalta, Peter W, Hecht, Stephen S

“…Acetaldehyde is a mutagen and carcinogen which occurs widely in the human environment, sometimes in considerable amounts, but little is known about its…”
Get full text

Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice by CONAWAY, C. Clifford, WANG, Chung-Xiou, PITTMAN, Brian, YANG, Yang-Ming, SCHWARTZ, Joel E, DEFA TIAN, MCINTEE, Edward J, HECHT, Stephen S, CHUNG, Fung-Lung

“…We have shown previously that naturally occurring isothiocyanates derived from cruciferous vegetables and their N-acetylcysteine conjugates inhibit lung…”
Get full text

Reactions of Formaldehyde Plus Acetaldehyde with Deoxyguanosine and DNA:  Formation of Cyclic Deoxyguanosine Adducts and Formaldehyde Cross-Links by Cheng, Guang, Shi, Yongli, Sturla, Shana J, Jalas, John R, McIntee, Edward J, Villalta, Peter W, Wang, Mingyao, Hecht, Stephen S

“…We investigated the reactions of formaldehyde plus acetaldehyde with dGuo and DNA in order to determine whether certain 1,N 2-propano-dGuo adducts could be…”
Get full text

Identification of Adducts Formed by Pyridyloxobutylation of Deoxyguanosine and DNA by 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a Chemically Activated Form of Tobacco Specific Carcinogens by Wang, Mingyao, Cheng, Guang, Sturla, Shana J, Shi, Yongli, McIntee, Edward J, Villalta, Peter W, Upadhyaya, Pramod, Hecht, Stephen S

“…The tobacco specific carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N‘-nitrosonornicotine (NNN) are metabolically activated to…”
Get full text

New DNA adducts of crotonaldehyde and acetaldehyde by Hecht, Stephen S., McIntee, Edward J., Wang, Mingyao

“…This paper summarizes our recent studies on adducts produced in the reactions of the carcinogens crotonaldehyde (2-butenal) and acetaldehyde with…”
Get full text

Utility of Laboratory Test Result Monitoring in Patients Taking Oral Terbinafine or Griseofulvin for Dermatophyte Infections by Stolmeier, Deirdre A, Stratman, Hannah B, McIntee, Thomas J, Stratman, Erik J

“…Terbinafine hydrochloride and griseofulvin are effective oral treatments for dermatophyte infections but have been associated with hepatic and hematologic…”
Get more information

Synthesis, in Vitro Anti-Breast Cancer Activity, and Intracellular Decomposition of Amino Acid Methyl Ester and Alkyl Amide Phosphoramidate Monoesters of 3‘-Azido-3‘-deoxythymidine (AZT) by Iyer, Vidhya V, Griesgraber, George W, Radmer, Matthew R, McIntee, Edward J, Wagner, Carston R

“…We report the synthesis and anticancer activity of a series of AZT phosphoramidate monoesters containing amino acid methyl ester (3a−11a) and N-alkyl amide…”
Get full text

Cutaneous findings in Bardet‐Biedl syndrome by Haws, Robert M., McIntee, Thomas J., Green, Clayton B.

“…Background Bardet‐Biedl syndrome (BBS) is a rare, pleiotropic syndrome and member of a diverse group of disorders known as ciliopathies. Improved understanding…”
Get full text

A geometric model of sensitivity of multistage elections to change by McIntee, Tomas J.

“…This paper geometrically compares multistage, multiple, and positional elections. The method of comparison shows that multiple stage elections are not…”
Get full text

Methodology of Evaluating the Laboratory Monitoring of Terbinafine Therapy-Reply by Stolmeier, Deirdre A, Stratman, Erik J, McIntee, Thomas J

Get more information

Identification of Adducts Formed in the Reaction of 5‘-Acetoxy-N‘-Nitrosonornicotine with Deoxyguanosine and DNA by Upadhyaya, Pramod, McIntee, Edward J, Villalta, Peter W, Hecht, Stephen S

“…N‘-Nitrosonornicotine (NNN) is believed to play an important role as a cause of cancer in people who use tobacco products and is considered to be a human…”
Get full text

Probing the Mechanism of Action and Decomposition of Amino Acid Phosphomonoester Amidates of Antiviral Nucleoside Prodrugs by McIntee, Edward J, Remmel, Rory P, Schinazi, Raymond F, Abraham, Timothy W, Wagner, Carston R

“…The decomposition pathways in peripheral blood mononuclear cells (PBMCs) and the in vitro anti-HIV-1 activity of the structurally similar…”
Get full text

Synthesis and Biological Activity of Aromatic Amino Acid Phosphoramidates of 5-Fluoro-2‘-deoxyuridine and 1-β-Arabinofuranosylcytosine:  Evidence of Phosphoramidase Activity by Abraham, Timothy W, Kalman, Thomas I, McIntee, Edward J, Wagner, Carston R

“…The amino acid phosphoramidate diesters of FUdR (2) and Ara-C (6), 5-fluoro-2‘-deoxy-5‘-uridyl N-(1-carbomethoxy-2-phenylethyl)phosphoramidate (5a),…”
Get full text

Implementing a Student-Designed Green Chemistry Laboratory Project in Organic Chemistry by Graham, Kate J, Jones, T. Nicholas, Schaller, Chris P, McIntee, Edward J

“…A multiweek organic chemistry laboratory project is described that emphasizes sustainable practices in experimental design. An emphasis on student-driven…”
Get full text

SAR of non-hydrolysable analogs of pyridoxal 5′-phosphate against low molecular weight protein tyrosine phosphatase isoforms by DeSouza, Shirin R., Olson, Maxwell C., Tinucci, Samantha L., Sinner, Erica K., Flynn, Rebecca S., Marshall, Quinlen F., Jakubowski, Henry V., McIntee, Edward J.

“…[Display omitted] Kinases and phosphatases are key enzymes in cell signal transduction pathways. Imbalances in these enzymes have been linked to numerous…”
Get full text

Enantiomeric composition of N′-nitrosonornicotine and N′-nitrosoanatabine in tobacco by Carmella, Steven G., McIntee, Edward J., Chen, Menglan, Hecht, Stephen S.

“…The tobacco-specific nitrosamines N′-nitrosonornicotine (NNN) and N′-nitrosoanatabine (NAT) are found in substantial quantities in unburned tobacco. Although…”
Get full text

A Schiff Base Is a Major DNA Adduct of Crotonaldehyde by Wang, Mingyao, McIntee, Edward J, Cheng, Guang, Shi, Yongli, Villalta, Peter W, Hecht, Stephen S

“…Previous studies have demonstrated that the reaction of crotonaldehyde with DNA produces Michael addition products, and these have been detected in human…”
Get full text

Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination by Hecht, Stephen S., Upadhyaya, Pramod, Wang, Mingyao, Bliss, Robin L., McIntee, Edward J., Kenney, Patrick M.J.

“…Isothiocyanates, their N-acetylcysteine conjugates, and myo-inositol (MI) are inhibitors of lung tumorigenesis in A/J mice. However, chemoprevention by…”
Get full text

Web-Based 2D NMR Spectroscopy Practice Problems by Graham, Kate J, McIntee, Edward J, Schaller, Chris P

“…2D NMR spectroscopy is regularly utilized for determination of organic structures. Problem-solving using a variety of 2D techniques is increasingly covered in…”
Get full text