Search Results - "McInnes, Iain B"

Pathogenetic insights from the treatment of rheumatoid arthritis by McInnes, Iain B, Prof, Schett, Georg, Prof

“…Summary Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular damage, functional loss, and comorbidity. The development of…”
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JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis by Fragoulis, George E, McInnes, Iain B, Siebert, Stefan

“…Abstract Janus kinase (JAK)/signal transducers and activators of transcription (STATs) are a group of molecules associated with one of the major pathways…”
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Cytokines in rheumatoid arthritis — shaping the immunological landscape by McInnes, Iain B., Buckley, Christopher D., Isaacs, John D.

“…The contributions of key cytokines in rheumatoid arthritis (RA) pathogenesis, including TNF, IL-1, JAK-dependent cytokines, GM-CSF and chemokines, can be…”
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Rheumatoid arthritis and depression: an inflammatory perspective by Nerurkar, Louis, Siebert, Stefan, McInnes, Iain B, Cavanagh, Jonathan

“…The coexistence of immune-mediated inflammatory diseases with depression has long been recognised. Data that illustrate the intimate associations between…”
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The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies by McGonagle, Dennis G, McInnes, Iain B, Kirkham, Bruce W, Sherlock, Jonathan, Moots, Robert

“…Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence…”
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Future therapeutic targets in rheumatoid arthritis? by Cheung, Tommy Tsang, McInnes, Iain B.

“…Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint inflammation. Without adequate treatment, patients with RA will…”
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Cytokines in the pathogenesis of rheumatoid arthritis by McInnes, Iain B, Schett, Georg

“…Cytokines regulate a broad range of inflammatory processes that are implicated in the pathogenesis of rheumatoid arthritis. In rheumatoid joints, it is well…”
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Cardiometabolic comorbidities in RA and PsA: lessons learned and future directions by Ferguson, Lyn D., Siebert, Stefan, McInnes, Iain B., Sattar, Naveed

“…Cardiometabolic comorbidities present a considerable burden for patients with rheumatoid arthritis (RA) or psoriatic arthritis (PsA). Both RA and PsA are…”
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Inflammatory mechanisms in tendinopathy – towards translation by Millar, Neal L., Murrell, George A. C., McInnes, Iain B.

“…Key Points Tendinopathy is a complex multi-faceted tendon pathology commonly associated with overuse Most current treatments for tendinopathy are neither…”
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The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention by O'Shea, John J, Schwartz, Daniella M, Villarino, Alejandro V, Gadina, Massimo, McInnes, Iain B, Laurence, Arian

“…The Janus kinase (JAK)-signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway…”
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COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options by Guzik, Tomasz J, Mohiddin, Saidi A, Dimarco, Anthony, Patel, Vimal, Savvatis, Kostas, Marelli-Berg, Federica M, Madhur, Meena S, Tomaszewski, Maciej, Maffia, Pasquale, D’Acquisto, Fulvio, Nicklin, Stuart A, Marian, Ali J, Nosalski, Ryszard, Murray, Eleanor C, Guzik, Bartlomiej, Berry, Colin, Touyz, Rhian M, Kreutz, Reinhold, Wang, Dao Wen, Bhella, David, Sagliocco, Orlando, Crea, Filippo, Thomson, Emma C, McInnes, Iain B

“…Abstract The novel coronavirus disease (COVID-19) outbreak, caused by SARS-CoV-2, represents the greatest medical challenge in decades. We provide a…”
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Why did IL-23p19 inhibition fail in AS: a tale of tissues, trials or translation? by Siebert, Stefan, Millar, Neal L, McInnes, Iain B

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Therapeutic Targeting of IL-17 and IL-23 Cytokines in Immune-Mediated Diseases by Fragoulis, George E, Siebert, Stefan, McInnes, Iain B

“…The discovery of the biological functions of the interleukin-23 -17 axis led to the identification of IL-23 and IL-17 as important participants in the…”
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Trial of Upadacitinib and Adalimumab for Psoriatic Arthritis by McInnes, Iain B, Anderson, Jaclyn K, Magrey, Marina, Merola, Joseph F, Liu, Yi, Kishimoto, Mitsumasa, Jeka, Slawomir, Pacheco-Tena, Cesar, Wang, Xin, Chen, Liang, Zueger, Patrick, Liu, John, Pangan, Aileen L, Behrens, Frank

“…In a trial comparing the JAK inhibitor upadacitinib (15 or 30 mg daily) with placebo and with the TNF-α inhibitor adalimumab, the percentage of patients with…”
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Disease-associated functions of IL-33: the new kid in the IL-1 family by Liew, Foo Y, Pitman, Nick I, McInnes, Iain B

“…Key Points Interleukin-33 (IL-33) is a newly described member of the IL-1 cytokine family. IL-33 is expressed by endothelial cells, fibroblasts and neuronal…”
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Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis by Gracey, Eric, Burssens, Arne, Cambré, Isabelle, Schett, Georg, Lories, Rik, McInnes, Iain B., Asahara, Hiroshi, Elewaut, Dirk

“…Mechanical loading is an important factor in musculoskeletal health and disease. Tendons and ligaments require physiological levels of mechanical loading to…”
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MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis by Alivernini, Stefano, Gremese, Elisa, McSharry, Charles, Tolusso, Barbara, Ferraccioli, Gianfranco, McInnes, Iain B, Kurowska-Stolarska, Mariola

“…MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a…”
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Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled, phase 3 trial by McInnes, Iain B, Prof, Mease, Philip J, Prof, Kirkham, Bruce, MD, Kavanaugh, Arthur, Prof, Ritchlin, Christopher T, Prof, Rahman, Proton, Prof, van der Heijde, Désirée, Prof, Landewé, Robert, Prof, Conaghan, Philip G, Prof, Gottlieb, Alice B, Prof, Richards, Hanno, MD, Pricop, Luminita, MD, Ligozio, Gregory, MSc, Patekar, Manmath, MD, Mpofu, Shephard, MD

“…Summary Background Interleukin 17A is a proinflammatory cytokine that is implicated in the pathogenesis of psoriatic arthritis. We assessed the efficacy and…”
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Comparison of baricitinib, upadacitinib, and tofacitinib mediated regulation of cytokine signaling in human leukocyte subpopulations by McInnes, Iain B, Byers, Nicole L, Higgs, Richard E, Lee, Jonathan, Macias, William L, Na, Songqing, Ortmann, Robert A, Rocha, Guilherme, Rooney, Terence P, Wehrman, Thomas, Zhang, Xin, Zuckerman, Steven H, Taylor, Peter C

“…The in vitro pharmacology of baricitinib, upadacitinib, and tofacitinib was evaluated to understand differences among these JAK inhibitors (JAKis) at the…”
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Efficacy and safety of secukinumab administration by autoinjector in patients with psoriatic arthritis: results from a randomized, placebo-controlled trial (FUTURE 3) by Nash, Peter, Mease, Philip J, McInnes, Iain B, Rahman, Proton, Ritchlin, Christopher T, Blanco, Ricardo, Dokoupilova, Eva, Andersson, Mats, Kajekar, Radhika, Mpofu, Shephard, Pricop, Luminita

“…The study aimed to assess 52-week efficacy and safety of secukinumab self-administration by autoinjector in patients with active psoriatic arthritis (PsA) in…”
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