Search Results - "McIlwain, R"

Caspase functions in cell death and disease by McIlwain, David R, Berger, Thorsten, Mak, Tak W

“…Caspases are a family of endoproteases that provide critical links in cell regulatory networks controlling inflammation and cell death. The activation of these…”
Get full text

Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front by Schürch, Christian M., Bhate, Salil S., Barlow, Graham L., Phillips, Darci J., Noti, Luca, Zlobec, Inti, Chu, Pauline, Black, Sarah, Demeter, Janos, McIlwain, David R., Kinoshita, Shigemi, Samusik, Nikolay, Goltsev, Yury, Nolan, Garry P.

“…Antitumoral immunity requires organized, spatially nuanced interactions between components of the immune tumor microenvironment (iTME). Understanding this…”
Get full text

ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs by Lee, Ivan T., Nakayama, Tsuguhisa, Wu, Chien-Ting, Goltsev, Yury, Jiang, Sizun, Gall, Phillip A., Liao, Chun-Kang, Shih, Liang-Chun, Schürch, Christian M., McIlwain, David R., Chu, Pauline, Borchard, Nicole A., Zarabanda, David, Dholakia, Sachi S., Yang, Angela, Kim, Dayoung, Chen, Han, Kanie, Tomoharu, Lin, Chia-Der, Tsai, Ming-Hsui, Phillips, Katie M., Kim, Raymond, Overdevest, Jonathan B., Tyler, Matthew A., Yan, Carol H., Lin, Chih-Feng, Lin, Yi-Tsen, Bau, Da-Tian, Tsay, Gregory J., Patel, Zara M., Tsou, Yung-An, Tzankov, Alexandar, Matter, Matthias S., Tai, Chih-Jaan, Yeh, Te-Huei, Hwang, Peter H., Nolan, Garry P., Nayak, Jayakar V., Jackson, Peter K.

“…The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory disease pandemic COVID-19. Tissue and cellular tropism is one key to…”
Get full text

A Comprehensive Atlas of Immunological Differences Between Humans, Mice, and Non-Human Primates by Bjornson-Hooper, Zachary B, Fragiadakis, Gabriela K, Spitzer, Matthew H, Chen, Han, Madhireddy, Deepthi, Hu, Kevin, Lundsten, Kelly, McIlwain, David R, Nolan, Garry P

“…Animal models are an integral part of the drug development and evaluation process. However, they are unsurprisingly imperfect reflections of humans, and the…”
Get full text

iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling by Li, Xue, Maretzky, Thorsten, Weskamp, Gisela, Monette, Sébastien, Qing, Xiaoping, Issuree, Priya Darshinee A., Crawford, Howard C., McIlwain, David R., Mak, Tak W., Salmon, Jane E., Blobel, Carl P.

“…The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF receptor (EGFR) signaling by liberating EGFR ligands from their membrane…”
Get full text

iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding by Maretzky, Thorsten, Mcllwain, David R., Issuree, Priya Darshinee A., Li, Xue, Malapeira, Jordi, Amin, Sadaf, Lang, Philipp A., Mak, Tak W., Blobel, Carl P.

“…Protein ectodomain shedding by ADAM17 (a disintegrin and metalloprotease 17), a principal regulator of EGF-receptor signaling and TNFα release, is rapidly and…”
Get full text

Single-Cell Profiling of Ebola Virus Disease In Vivo Reveals Viral and Host Dynamics by Kotliar, Dylan, Lin, Aaron E., Logue, James, Hughes, Travis K., Khoury, Nadine M., Raju, Siddharth S., Wadsworth, Marc H., Chen, Han, Kurtz, Jonathan R., Dighero-Kemp, Bonnie, Bjornson, Zach B., Mukherjee, Nilanjan, Sellers, Brian A., Tran, Nancy, Bauer, Matthew R., Adams, Gordon C., Adams, Ricky, Rinn, John L., Melé, Marta, Schaffner, Stephen F., Nolan, Garry P., Barnes, Kayla G., Hensley, Lisa E., McIlwain, David R., Shalek, Alex K., Sabeti, Pardis C., Bennett, Richard S.

“…Ebola virus (EBOV) causes epidemics with high mortality yet remains understudied due to the challenge of experimentation in high-containment and outbreak…”
Get full text

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis by Issuree, Priya Darshinee A, Maretzky, Thorsten, McIlwain, David R, Monette, Sébastien, Qing, Xiaoping, Lang, Philipp A, Swendeman, Steven L, Park-Min, Kyung-Hyun, Binder, Nikolaus, Kalliolias, George D, Yarilina, Anna, Horiuchi, Keisuke, Ivashkiv, Lionel B, Mak, Tak W, Salmon, Jane E, Blobel, Carl P

“…iRHOM2, encoded by the gene Rhbdf2, regulates the maturation of the TNF-α convertase (TACE), which controls shedding of TNF-α and its biological activity in…”
Get full text

Plasma concentrations of inflammatory cytokines rise rapidly during ECMO-related SIRS due to the release of preformed stores in the intestine by McILwain, R Britt, Timpa, Joseph G, Kurundkar, Ashish R, Holt, David W, Kelly, David R, Hartman, Yolanda E, Neel, Mary Lauren, Karnatak, Rajendra K, Schelonka, Robert L, Anantharamaiah, G M, Killingsworth, Cheryl R, Maheshwari, Akhil

“…Extracorporeal membrane oxygenation (ECMO) is a life-saving support system used in neonates and young children with severe cardiorespiratory failure. Although…”
Get full text

Glutathione peroxidase 3 is a potential biomarker for konzo by Bramble, Matthew S., Fourcassié, Victor, Vashist, Neerja, Roux-Dalvai, Florence, Zhou, Yun, Bumoko, Guy, Kasendue, Michel Lupamba, Spencer, D’Andre, Musasa Hanshi-Hatuhu, Hilaire, Kambale-Mastaki, Vincent, Manalo, Rafael Vincent M., Mohammed, Aliyah, McIlwain, David R., Cunningham, Gary, Summar, Marshall, Boivin, Michael J., Caldovic, Ljubica, Vilain, Eric, Mumba-Ngoyi, Dieudonne, Tshala-Katumbay, Desire, Droit, Arnaud

“…Konzo is a neglected paralytic neurological disease associated with food (cassava) poisoning that affects the world’s poorest children and women of…”
Get full text

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay by McIlwain, David R., Pan, Qun, Reilly, Patrick T., Elia, Andrew J., McCracken, Susan, Wakeham, Andrew C., Itie-Youten, Annick, Blencowe, Benjamin J., Mak, Tak W.

“…Smg1 is a PI3K-related kinase (PIKK) associated with multiple cellular functions, including DNA damage responses, telomere maintenance, and nonsense-mediated…”
Get full text

Adjacent Cell Marker Lateral Spillover Compensation and Reinforcement for Multiplexed Images by Bai, Yunhao, Zhu, Bokai, Rovira-Clave, Xavier, Chen, Han, Markovic, Maxim, Chan, Chi Ngai, Su, Tung-Hung, McIlwain, David R, Estes, Jacob D, Keren, Leeat, Nolan, Garry P, Jiang, Sizun

“…Multiplex imaging technologies are now routinely capable of measuring more than 40 antibody-labeled parameters in single cells. However, lateral spillage of…”
Get full text

Intestinal epithelial apoptosis initiates gut mucosal injury during extracorporeal membrane oxygenation in the newborn piglet by MohanKumar, Krishnan, Killingsworth, Cheryl R, Britt McILwain, R, Timpa, Joseph G, Jagadeeswaran, Ramasamy, Namachivayam, Kopperuncholan, Kurundkar, Ashish R, Kelly, David R, Garzon, Steven A, Maheshwari, Akhil

“…Neonates and young infants exposed to extracorporeal circulation during extracorporeal membrane oxygenation (ECMO) and cardiopulmonary bypass are at risk of…”
Get full text

Functional comparison of PBMCs isolated by Cell Preparation Tubes (CPT) vs. Lymphoprep Tubes by Chen, Han, Schürch, Christian M, Noble, Kevin, Kim, Kenneth, Krutzik, Peter O, O'Donnell, Erika, Vander Tuig, Jason, Nolan, Garry P, McIlwain, David R

“…Cryopreserved human peripheral blood mononuclear cells (PBMCs) are a commonly used sample type for a variety of immunological assays. Many factors can affect…”
Get full text

Early biological markers of post-acute sequelae of SARS-CoV-2 infection by Lu, Scott, Peluso, Michael J., Glidden, David V., Davidson, Michelle C., Lugtu, Kara, Pineda-Ramirez, Jesus, Tassetto, Michel, Garcia-Knight, Miguel, Zhang, Amethyst, Goldberg, Sarah A., Chen, Jessica Y., Fortes-Cobby, Maya, Park, Sara, Martinez, Ana, So, Matthew, Donovan, Aidan, Viswanathan, Badri, Hoh, Rebecca, Donohue, Kevin, McIlwain, David R., Gaudiliere, Brice, Anglin, Khamal, Yee, Brandon C., Chenna, Ahmed, Winslow, John W., Petropoulos, Christos J., Deeks, Steven G., Briggs-Hagen, Melissa, Andino, Raul, Midgley, Claire M., Martin, Jeffrey N., Saydah, Sharon, Kelly, J. Daniel

“…To understand the roles of acute-phase viral dynamics and host immune responses in post-acute sequelae of SARS-CoV-2 infection (PASC), we enrolled 136…”
Get full text

The xenoestrogens biphenol‐A and nonylphenol differentially regulate metalloprotease‐mediated shedding of EGFR ligands by Urriola‐Muñoz, Paulina, Li, Xue, Maretzky, Thorsten, McIlwain, David R., Mak, Tak W., Reyes, Juan G., Blobel, Carl P., Moreno, Ricardo D.

“…The xenoestrogens bisphenol‐A (BPA) and nonylphenol (NP) are endocrine disruptors used in the plastic polymer industry to manufacture different products for…”
Get full text

Role of iRhoms 1 and 2 in Endochondral Ossification by Fang, Renpeng, Haxaire, Coline, Otero, Miguel, Lessard, Samantha, Weskamp, Gisela, McIlwain, David R, Mak, Tak W, Lichtenthaler, Stefan F, Blobel, Carl P

“…Growth of the axial and appendicular skeleton depends on endochondral ossification, which is controlled by tightly regulated cell-cell interactions in the…”
Get full text

iRhom2 regulates CSF1R cell surface expression and non‐steady state myelopoiesis in mice by Qing, Xiaoping, D. Rogers, Lindsay, Mortha, Arthur, Lavin, Yonit, Redecha, Patricia, Issuree, Priya D., Maretzky, Thorsten, Merad, Miriam, R. McIlwain, David, Mak, Tak W., Overall, Christopher M., Blobel, Carl P., Salmon, Jane E.

“…CSF1R (colony stimulating factor 1 receptor) is the main receptor for CSF1 and has crucial roles in regulating myelopoeisis. CSF1R can be proteolytically…”
Get full text

Variation of Immune Cell Responses in Humans Reveals Sex-Specific Coordinated Signaling Across Cell Types by Fragiadakis, Gabriela K, Bjornson-Hooper, Zachary B, Madhireddy, Deepthi, Sachs, Karen, Chen, Han, McIlwain, David R, Spitzer, Matthew H, Bendall, Sean C, Nolan, Garry P

“…Assessing the health and competence of the immune system is central to evaluating vaccination responses, autoimmune conditions, cancer prognosis, and…”
Get full text

Performance of BioFire array or QuickVue influenza A + B test versus a validation qPCR assay for detection of influenza A during a volunteer A/California/2009/H1N1 challenge study by McIlwain, David R, Chen, Han, Apkarian, Maria, Affrime, Melton, Bock, Bonnie, Kim, Kenneth, Mukherjee, Nilanjan, Nolan, Garry P, McNeal, Monica M

“…Influenza places a significant burden on global health and economics. Individual case management and public health efforts to mitigate the spread of influenza…”
Get full text