Search Results - "McIlroy, Marie"

The Divergent Function of Androgen Receptor in Breast Cancer; Analysis of Steroid Mediators and Tumor Intracrinology by Bleach, Rachel, McIlroy, Marie

“…Androgen receptor (AR) is the most widely expressed steroid receptor protein in normal breast tissue and is detectable in approximately 90% of primary breast…”
Get full text

Steroid Ligands, the Forgotten Triggers of Nuclear Receptor Action; Implications for Acquired Resistance to Endocrine Therapy by Bleach, Rachel, Madden, Stephen F, Hawley, James, Charmsaz, Sara, Selli, Cigdem, Sheehan, Katherine M, Young, Leonie S, Sims, Andrew H, Souček, Pavel, Hill, Arnold D, McIlroy, Marie

“…There is strong epidemiologic evidence indicating that estrogens may not be the sole steroid drivers of breast cancer. We hypothesize that abundant adrenal…”
Get full text

Growth Hormone/Insulin Growth Factor Axis in Sex Steroid Associated Disorders and Related Cancers by Bleach, Rachel, Sherlock, Mark, O'Reilly, Michael W, McIlroy, Marie

“…To date, almost all solid malignancies have implicated insulin-like growth factor (IGF) signalling as a driver of tumour growth. However, the remarkable level…”
Get full text

Prosaposin activates the androgen receptor and potentiates resistance to endocrine treatment in breast cancer by Ali, Azlena, Creevey, Laura, Hao, Yuan, McCartan, Damian, O'Gaora, Peadar, Hill, Arnold, Young, Leonie, McIlroy, Marie

“…HOX genes play vital roles in growth and development, however, atypical redeployment of these genes is often associated with steroidal adaptability in…”
Get full text

Characterizing skeletal muscle dysfunction in women with polycystic ovary syndrome by McDonnell, Tara, Cussen, Leanne, McIlroy, Marie, O’Reilly, Michael W.

“…Polycystic ovary syndrome (PCOS) is the most common endocrine condition affecting women. It has traditionally been viewed as a primarily reproductive disorder;…”
Get full text

Global Characterization of the SRC-1 Transcriptome Identifies ADAM22 as an ER-Independent Mediator of Endocrine-Resistant Breast Cancer by MCCARTAN, Damian, BOLGER, Jarlath C, YOUNG, Leonie S, FAGAN, Ailis, BYRNE, Christopher, YUAN HAO, LI QIN, MCLLROY, Marie, JIANMING XU, HILL, Arnold D, GAORA, Peadaro

“…The development of breast cancer resistance to endocrine therapy results from an increase in cellular plasticity that permits the emergence of a…”
Get full text

S100β as a serum marker in endocrine resistant breast cancer by Charmsaz, Sara, Hughes, Éamon, Bane, Fiona T, Tibbitts, Paul, McIlroy, Marie, Byrne, Christopher, Cocchiglia, Sinéad, McBryan, Jean, Hennessy, Bryan T, Dwyer, Róisín M, Kerin, Michael J, Hill, Arnold D, Young, Leonie S

“…Endocrine therapy is standard treatment for estrogen receptor (ER)-positive breast cancer. However, its efficacy is limited by intrinsic and acquired…”
Get full text

Coassociation of Estrogen Receptor and p160 Proteins Predicts Resistance to Endocrine Treatment; SRC-1 is an Independent Predictor of Breast Cancer Recurrence by REDMOND, Aisling M, BANE, Fiona T, STAFFORD, Anthony T, MCLLROY, Marie, DILLON, Mary F, CROTTY, Thomas B, HILL, Arnold D, YOUNG, Leonie S

“…Purpose: This study investigates the role of the p160 coactivators AIB1 and SRC-1 independently, and their interactions with the estrogen receptor, in the…”
Get full text

Extra-nuclear and cytoplasmic steroid receptor signalling in hormone dependent cancers by Agbana, Stephanie, McIlroy, Marie

“…Steroid hormone receptors are key mediators in the execution of hormone action through a combination of genomic and non-genomic action. Since their isolation…”
Get full text

The role of oestrogen receptor α in human thyroid cancer: contributions from coregulatory proteins and the tyrosine kinase receptor HER2 by Kavanagh, Dara O, McIlroy, Marie, Myers, Eddie, Bane, Fiona, Crotty, Thomas B, McDermott, E, Hill, Arnold D, Young, Leonie S

“…Epidemiological, clinical, and molecular studies suggest a role for oestrogen in thyroid cancer. How oestrogen mediates its effects and the consequence of it…”
Get full text

Disability studies in and for inclusive teacher education in Aotearoa New Zealand by Morton, Missy, McIlroy, Anne-Marie, Macarthur, Jude, Olsen, Paul

“…In inclusive education, Disability Studies is a framework that has been useful for identifying gaps in theory, in practice and the spaces in between…”
Get full text

Re-expression of ERalpha in ER negative breast cancer cells following trastuzumab treatment by Solon, Gemma, MB BCh, McIlroy, Marie, PhD, Collins, D., PhD, MB BCh, Hill, Arnold D.K., MD, Young, Leonie, PhD

Get full text

Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients by Dillon, Mary F, Stafford, Anthony T, Kelly, Gabrielle, Redmond, Aisling M, McIlroy, Marie, Crotty, Thomas B, McDermott, E, Hill, Arnold D, Young, Leonie S

“…Cyclooxygenase-2 (COX-2) is associated with breast tumour progression. Clinical and molecular studies implicate human epidermal growth factor receptor 2 (HER2)…”
Get full text

Special Issue - Steroid Receptor Signalling in Hormone Dependent Cancers: a 5-year perspective by Agbana, Stephanie, McIlroy, Marie

“…Steroid hormone receptors are key mediators in the execution of hormone action through a combination of genomic and non-genomic action. Since their isolation…”
Get full text

Identifying teachers' strengths to face COVID-19: narratives from across the globe by Aiello, Paola, Pace, Erika Marie, Sharma, Umesh, Rangarajan, Rashmi, Sokal, Laura, May, Fiona, Gonzalez Gil, Francisca, Loreman, Tim, Malak, Saiful, Martín, Elena, McIlroy, Anne-Marie, Schwab, Susanne

“…An appreciative inquiry approach oriented eight semi-structured interviews conducted with teachers from Australia, New Zealand, Austria, Italy, Spain, Canada,…”
Get full text

Mechanisms in Endocrinology: Hypogonadism and metabolic health in men - novel insights into pathophysiology by Miller, Clare, Madden-Doyle, Lauren, Jayasena, Channa, McIlroy, Marie, Sherlock, Mark, O'Reilly, Michael W

“…Hypogonadism in men is associated with an adverse metabolic phenotype and increased mortality. Reciprocally, obesity and insulin resistance can suppress the…”
Get full text

Assessment, Curriculum and Literacy Practices to Develop and Support Social Relationships in a New Zealand Primary School by Mcilroy, Anne-Marie

“…Abstract Narrative assessment is a strengths-based approach that stories children’s learning and makes visible teaching and relationships that are critical to…”
Get full text

Abstract LB-258: Upregulation of androgen receptor in breast cancer is associated with more aggressive disease when PI3K signaling is active by Ali, Azlena, Creevey, Laura, Hill, Arnold, Young, Leonie, McIlroy, Marie

“…Abstract Endocrine treatment has been the therapeutic mainstay for hormone receptor positive breast cancer; however, as with all drugs, the development of…”
Get full text

Impaired 11β-hydroxysteroid dehydrogenase type 2 activity in kidney disease disrupts 11-oxygenated androgen biosynthesis by Tomkins, Maria, McDonnell, Tara, Cussen, Leanne, Sagmeister, Michael S, Oestlund, Imken, Shaheen, Fozia, Harper, Lorraine, Hardy, Rowan S, Taylor, Angela E, Gilligan, Lorna C, Arlt, Wiebke, McIlroy, Marie, de Freitas, Declan, Conlon, Peter, Magee, Colm, Denton, Mark, O'Seaghdha, Conall, Snoep, Jacky L, Storbeck, Karl-Heinz, Sherlock, Mark, O'Reilly, Michael W

“…11-oxygenated androgens are a group of adrenal-derived steroids that require peripheral activation. In vitro data highlight a putative role for…”
Get full text

Altered Steroid Milieu in AI-Resistant Breast Cancer Facilitates AR Mediated Gene-Expression Associated with Poor Response to Therapy by Creevey, Laura, Bleach, Rachel, Madden, Stephen F, Toomey, Sinead, Bane, Fiona T, Varešlija, Damir, Hill, Arnold D, Young, Leonie S, McIlroy, Marie

“…Divergent roles for androgen receptor (AR) in breast cancer have been reported. Following aromatase inhibitor (AI) treatment, the conversion of circulating…”
Get full text