Search Results - "McHugh, Stephen B"

Hippocampal synaptic plasticity, spatial memory and anxiety by Bannerman, David M., Sprengel, Rolf, Sanderson, David J., McHugh, Stephen B., Rawlins, J. Nicholas P., Monyer, Hannah, Seeburg, Peter H.

“…In this Perspective, Seeburg and colleagues re-examine the role of the hippocampus in spatial learning in light of recent findings. They also suggest that the…”
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Adult-born dentate granule cells promote hippocampal population sparsity by McHugh, Stephen B., Lopes-dos-Santos, Vítor, Gava, Giuseppe P., Hartwich, Katja, Tam, Shu K. E., Bannerman, David M., Dupret, David

“…The dentate gyrus (DG) gates neocortical information flow to the hippocampus. Intriguingly, the DG also produces adult-born dentate granule cells (abDGCs)…”
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Hippocampal NMDA receptors and anxiety: At the interface between cognition and emotion by Barkus, Christopher, McHugh, Stephen B., Sprengel, Rolf, Seeburg, Peter H., Rawlins, J. Nicholas P., Bannerman, David M.

“…David De Wied had a fundamental interest in the brain and behaviour, with a particular interest in the interface between cognition and emotion, and how…”
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Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model by Groves, James O, Leslie, Isla, Huang, Guo-Jen, McHugh, Stephen B, Taylor, Amy, Mott, Richard, Munafò, Marcus, Bannerman, David M, Flint, Jonathan

“…The function of adult neurogenesis in the rodent brain remains unclear. Ablation of adult born neurons has yielded conflicting results about emotional and…”
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Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala by Bocchio, Marco, Fucsina, Giulia, Oikonomidis, Lydia, McHugh, Stephen B, Bannerman, David M, Sharp, Trevor, Capogna, Marco

“…Genetic association studies suggest that variations in the 5-hydroxytryptamine (5-HT; serotonin) transporter (5-HTT) gene are associated with susceptibility to…”
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Serotonin, Amygdala and Fear: Assembling the Puzzle by Bocchio, Marco, McHugh, Stephen B, Bannerman, David M, Sharp, Trevor, Capogna, Marco

“…The fear circuitry orchestrates defense mechanisms in response to environmental threats. This circuitry is evolutionarily crucial for survival, but its…”
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Spatial working memory deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation: Evidence for Wagner's dual-process memory model by Sanderson, David J., McHugh, Stephen B., Good, Mark A., Sprengel, Rolf, Seeburg, Peter H., Rawlins, J. Nicholas P., Bannerman, David M.

“…Genetically modified mice, lacking the GluA1 AMPA receptor subunit, are impaired on spatial working memory tasks, but display normal acquisition of spatial…”
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Integrating new memories into the hippocampal network activity space by Gava, Giuseppe P., McHugh, Stephen B., Lefèvre, Laura, Lopes-dos-Santos, Vítor, Trouche, Stéphanie, El-Gaby, Mohamady, Schultz, Simon R., Dupret, David

“…By investigating the topology of neuronal co-activity, we found that mnemonic information spans multiple operational axes in the mouse hippocampus network…”
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Organizing the coactivity structure of the hippocampus from robust to flexible memory by Gava, Giuseppe P, Lefèvre, Laura, Broadbelt, Tabitha, McHugh, Stephen B, Lopes-Dos-Santos, Vítor, Brizee, Demi, Hartwich, Katja, Sjoberg, Hanna, Perestenko, Pavel V, Toth, Robert, Sharott, Andrew, Dupret, David

“…New memories are integrated into prior knowledge of the world. But what if consecutive memories exert opposing demands on the host brain network? We report…”
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Enhanced discriminative aversive learning and amygdala responsivity in 5-HT transporter mutant mice by Lima, João, Sharp, Trevor, Bannerman, David M., McHugh, Stephen B.

“…Genetic variation in the human serotonin transporter (5-HTT) has been linked to altered fear learning but the data are inconsistent and the mechanism is…”
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Aversive prediction error signals in the amygdala by McHugh, Stephen B, Barkus, Christopher, Huber, Anna, Capitão, Liliana, Lima, João, Lowry, John P, Bannerman, David M

“…Prediction error signals are fundamental to learning. Here, in mice, we show that aversive prediction signals are found in the hemodynamic responses and theta…”
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Brain tissue oxygen amperometry in behaving rats demonstrates functional dissociation of dorsal and ventral hippocampus during spatial processing and anxiety by McHugh, Stephen B., Fillenz, Marianne, Lowry, John P., Rawlins, J. Nicolas P., Bannerman, David M.

“…Traditionally, the function of the hippocampus (HPC) has been viewed in unitary terms, but there is growing evidence that the HPC is functionally…”
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Variation in Serotonin Transporter Expression Modulates Fear-Evoked Hemodynamic Responses and Theta-Frequency Neuronal Oscillations in the Amygdala by Barkus, Christopher, Line, Samantha J, Huber, Anna, Capitao, Liliana, Lima, Joao, Jennings, Katie, Lowry, John, Sharp, Trevor, Bannerman, David M, McHugh, Stephen B

“…Background Gene association studies detect an influence of natural variation in the 5-hydroxytryptamine transporter (5-HTT) gene on multiple aspects of…”
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Real-time electrochemical monitoring of brain tissue oxygen: A surrogate for functional magnetic resonance imaging in rodents by Lowry, John P., Griffin, Karen, McHugh, Stephen B., Lowe, Andrew S., Tricklebank, Mark, Sibson, Nicola R.

“…Long-term in-vivo electrochemistry (LIVE) enables real-time monitoring and measurement of brain metabolites. In this study we have simultaneously obtained…”
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Hippocampal Acetylcholine Depletion Has No Effect on Anxiety, Spatial Novelty Preference, or Differential Reward for Low Rates of Responding (DRL) Performance in Rats by McHugh, Stephen B., Francis, Anna, McAuley, J. Devin, Stewart, Amanda L., Baxter, Mark G., Bannerman, David M.

“…We investigated the role of the septo-hippocampal cholinergic projection in anxiety, spatial novelty preference, and differential reward for low rates of…”
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Characterisation of carbon paste electrodes for real-time amperometric monitoring of brain tissue oxygen by Bolger, Fiachra B., McHugh, Stephen B., Bennett, Rachel, Li, Jennifer, Ishiwari, Keita, Francois, Jennifer, Conway, Michael W., Gilmour, Gary, Bannerman, David M., Fillenz, Marianne, Tricklebank, Mark, Lowry, John P.

“…▶ High sensitivity, low detection limit and good linear response characteristics. ▶ No effect of pH, temperature, ion changes, and no dependence upon fluid…”
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Dorsal hippocampal N-methyl-d-aspartate receptors underlie spatial working memory performance during non-matching to place testing on the T-maze by McHugh, Stephen B., Niewoehner, Burkhard, Rawlins, J.N.P., Bannerman, David M.

“…Previous lesion studies have suggested a functional dissociation along the septotemporal axis of the hippocampus. Whereas the dorsal hippocampus has been…”
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Hemodynamic responses in amygdala and hippocampus distinguish between aversive and neutral cues during Pavlovian fear conditioning in behaving rats by McHugh, Stephen B., Marques-Smith, Andre, Li, Jennifer, Rawlins, J. N. P., Lowry, John, Conway, Michael, Gilmour, Gary, Tricklebank, Mark, Bannerman, David M.

“…Amygdala and hippocampal tissue oxygen (TO2) signals were recorded from freely‐moving rats during discriminative Pavlovian fear conditioning. TO2 signals…”
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Close temporal coupling of neuronal activity and tissue oxygen responses in rodent whisker barrel cortex by Li, Jennifer, Bravo, Diego S., Louise Upton, A., Gilmour, Gary, Tricklebank, Mark D., Fillenz, Marianne, Martin, Chris, Lowry, John P., Bannerman, David M., McHugh, Stephen B.

“…Neuronal activity elicits metabolic and vascular responses, during which oxygen is first consumed and then supplied to the tissue via an increase in cerebral…”
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Ablating Adult Neurogenesis in the Rat Has No Effect on Spatial Processing: Evidence from a Novel Pharmacogenetic Model: e1003718 by Groves, James O, Leslie, Isla, Huang, Guo-Jen, McHugh, Stephen B, Taylor, Amy, Mott, Richard, Munafò, Marcus, Bannerman, David M, Flint, Jonathan

“…The function of adult neurogenesis in the rodent brain remains unclear. Ablation of adult born neurons has yielded conflicting results about emotional and…”
Get full text