Search Results - "McHugh, Simon M"

Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells by Wilson, Paul A, Santos Franco, Sara, He, Liu, Galwey, Nicholas W, Meakin, Jackie, McIntyre, Rebecca, McHugh, Simon M, Nolan, Michael A, Spain, Sarah L, Carlson, Thaddeus, Lobera, Mercedes, Rubio, Justin P, Davis, Bill, McCarthy, Linda C

“…RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven…”
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Identification of BDNF sensitive electrophysiological markers of synaptic activity and their structural correlates in healthy subjects using a genetic approach utilizing the functional BDNF Val66Met polymorphism by Soltész, Fruzsina, Suckling, John, Lawrence, Phil, Tait, Roger, Ooi, Cinly, Bentley, Graham, Dodds, Chris M, Miller, Sam R, Wille, David R, Byrne, Misha, McHugh, Simon M, Bellgrove, Mark A, Croft, Rodney J, Lu, Bai, Bullmore, Edward T, Nathan, Pradeep J

“…Increasing evidence suggests that synaptic dysfunction is a core pathophysiological hallmark of neurodegenerative disorders. Brain-derived neurotropic factor…”
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Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells by Paul A Wilson, Sara Santos Franco, Liu He, Nicholas W Galwey, Jackie Meakin, Rebecca McIntyre, Simon M McHugh, Michael A Nolan, Sarah L Spain, Thaddeus Carlson, Mercedes Lobera, Justin P Rubio, Bill Davis, Linda C McCarthy

“…RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven…”
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Use of Entero‐Test, a simple approach for non‐invasive clinical evaluation of the biliary disposition of drugs by Guiney, William J., Beaumont, Claire, Thomas, Steve R., Robertson, Darren C., McHugh, Simon M., Koch, Annelize, Richards, Duncan

“…WHAT IS ALREADY KNOWN ABOUT THE SUBJECT • Biliary secretion is often a major route of elimination of drugs and metabolites. Knowledge of the biliary…”
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Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X7 receptor antagonist: a prospective genotyping approach by McHugh, Simon M., Roman, Shilina, Davis, Bill, Koch, Annelize, Pickett, Alison M., Richardson, Jill C., Miller, Sam R., Wetten, Sally, Cox, Charles J., Karpe, Fredrik, Todd, John A., Bullmore, Edward T.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Analysis of allelic variation in large populations has identified numerous single nucleotide polymorphisms (SNPs) in…”
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A pilot study to assess the feasibility of measurement of adrenal gland volume by magnetic resonance imaging by Grant, Lee A, Napolitano, Antonella, Miller, Sam, Stephens, Kimberley, McHugh, Simon M, Dixon, Adrian K

“…Repeated computed tomography (CT) assessment of the adrenal glands is associated with a significant radiation burden. The increasing capabilities of magnetic…”
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Differential effect of thalidomide and dexamethasone on the transcription factor NF-κB by Rowland, Tom L, McHugh, Simon M, Deighton, John, Ewan, Pamela W, Dearman, Rebecca J, Kimber, Ian

“…Thalidomide was initially used as a sedative during pregnancy but was withdrawn from the market due to its teratogenic effects. In vitro studies have shown…”
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Selective down-regulation of T cell- and non-T cell-derived tumour necrosis factor α by thalidomide: comparisons with dexamethasone by Rowland, Tom L, McHugh, Simon M, Deighton, John, Ewan, Pamela W, Dearman, Rebecca J, Kimber, Ian

“…Both thalidomide and dexamethasone have been shown to inhibit the production of tumour necrosis factor α (TNF-α), but little is known of their cellular…”
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Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X 7 receptor antagonist: a prospective genotyping approach by McHugh, Simon M., Roman, Shilina, Davis, Bill, Koch, Annelize, Pickett, Alison M., Richardson, Jill C., Miller, Sam R., Wetten, Sally, Cox, Charles J., Karpe, Fredrik, Todd, John A., Bullmore, Edward T.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Analysis of allelic variation in large populations has identified numerous single nucleotide polymorphisms (SNPs) in…”
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Ofatumumab, a Human Mab Targeting a Membrane-Proximal Small-Loop Epitope On CD20, Induces Potent NK Cell-Mediated ADCC by Craigen, Jenny L, Mackus, Wendy J.M., Engleberts, Patrick, Miller, Sam R, Speller, Sue, Chamberlain, Louise C, Davis, Bill G, McHugh, Simon M, Bullmore, Ed, Cox, Charles J, Wetten, Sally, Perdock, Gerrard, Bakker, Joost M, van de Winkel, Jan G.J., Parren, Paul W. H.I.

“…Abstract 1725 Poster Board I-751 CD20 represents a well established target for immunotherapy of B-cell malignancies such as follicular lymphoma (FL). The…”
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To bee or not to be? T‐cell responses to bee venom PLA 2 in relation to anaphylaxis and immunotherapy by McHugh, Simon M.

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Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X(7) receptor antagonist: a prospective genotyping approach by McHugh, Simon M, Roman, Shilina, Davis, Bill, Koch, Annelize, Pickett, Alison M, Richardson, Jill C, Miller, Sam R, Wetten, Sally, Cox, Charles J, Karpe, Fredrik, Todd, John A, Bullmore, Edward T

“…To investigate the effects of two single nucleotide polymorphisms (SNPs) in the human P2X₇ receptor gene (P2RX7)--1068G>A (A348T) and 1513A>C (E496A)--on P2X₇…”
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To bee or not to be? T-cell responses to bee venom PLA2 in relation to anaphylaxis and immunotherapy by McHugh, Simon M.

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Differential regulation by thalidomide and dexamethasone of cytokine expression in human peripheral blood mononuclear cells by Rowland, Tom L., McHugh, Simon M., Deighton, John, Dearman, Rebecca J., Ewan, Pamela W., Kimber, Ian

“…Immunosuppressive drugs are used routinely to reduce the inappropriate production of cytokines in an immune response. Recent attention has focused on drugs…”
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