Search Results - "McHugh, P. J."

Incidence and reflection of internal waves and wave-induced currents at a jump in buoyancy frequency by McHugh, J. P.

“…Weakly nonlinear internal gravity waves are treated in a two-layer fluid with a set of nonlinear Schrodinger equations. The layers have a sharp interface with…”
Get full text

Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma by MacGregor, T. P., Carter, R., Gillies, R. S., Findlay, J. M., Kartsonaki, C., Castro-Giner, F., Sahgal, N., Wang, L. M., Chetty, R., Maynard, N. D., Cazier, J. B., Buffa, F., McHugh, P. J., Tomlinson, I., Middleton, M. R., Sharma, R. A.

“…Oxaliplatin-based chemotherapy is used to treat patients with esophageal adenocarcinoma (EAC), but no biomarkers are currently available for patient selection…”
Get full text

Defining the Roles of Nucleotide Excision Repair and Recombination in the Repair of DNA Interstrand Cross-Links in Mammalian Cells by De Silva, Inusha U., McHugh, Peter J., Clingen, Peter H., Hartley, John A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Large variations in balloon ascent rate over Hawaii by McHugh, J. P., Dors, I., Jumper, G. Y., Roadcap, J. R., Murphy, E. A., Hahn, D. C.

“…A sequence of nine weather balloons were launched recently over the island of Hawaii during the nights of 12, 13, and 17 December, 2002, providing measurements…”
Get full text

Nonlinear evolution of a thin anodic film by McHugh, J. P., Barkey, D.

“…The formation of pores in anodic aluminium oxide films is treated with a model equation. The model treats the oxide layer as a thin viscous liquid in two…”
Get full text

Dynamic stability of a jet near a transition in static stability by McHugh, J. P., Sharman, R. D.

“…The vertical profile of the Earth's atmosphere in middle latitudes contains a sharp transition region between two roughly constant stability layers, termed the…”
Get full text

Novel reagents for chemical cleavage at abasic sites and UV photoproducts in DNA by McHugh, Peter J., Knowland, John

“…Hot piperidine is often used to cleave abasic and UV-irradiated DNA at the sites of damage. It can inflict non-specific damage on DNA, probably because it Is a…”
Get full text

Is epidural analgesia associated with an improved outcome following open Nissen fundoplication? by Wilson, G.A.M., Brown, J.L., Crabbe, D.G., Hinton, W., Mchugh, P.J., Stringer, M.D.

“…Postoperative epidural analgesia is increasingly popular in paediatric practice, although evidence of its benefit is scarce. We performed a retrospective…”
Get full text

Excision repair of nitrogen mustard-DNA adducts in Saccharomyces cerevisiae by McHugh, P.J, Gill, R.D, Waters, R, Hartley, J.A

“…The bifunctional alkylating anticancer drug nitrogen mustard forms a variety of DNA lesions, including monoadducts and intrastrand and interstrand crosslinks…”
Get full text

Global iron-dependent gene regulation in Escherichia coli. A new mechanism for iron homeostasis by McHugh, Jonathan P, Rodríguez-Quinoñes, Francisco, Abdul-Tehrani, Hossein, Svistunenko, Dimitri A, Poole, Robert K, Cooper, Chris E, Andrews, Simon C

“…Organisms generally respond to iron deficiency by increasing their capacity to take up iron and by consuming intracellular iron stores. Escherichia coli, in…”
Get full text

Velocity spectra and turbulence using direct detection lidar and comparison with thermosonde measurements by Dors, I., McHugh, J. P., Jumper, G. Y., Roadcap, J.

“…Observations of turbulence have been performed in New Hampshire near Mount Washington using two independent instruments: a ground‐based direct detection…”
Get full text

Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis by Merryweather-Clarke, Alison T., Cadet, Estelle, Bomford, Adrian, Capron, Dominique, Viprakasit, Vip, Miller, Anne, McHugh, Paddy J., Chapman, Roger W., Pointon, Jennifer J., Wimhurst, Victoria L.C., Livesey, Karen J., Tanphaichitr, Voravarn, Rochette, Jacques, Robson, Kathryn J.H.

“…Haemochromatosis (HH) is a clinically and genetically heterogeneous disease caused by inappropriate iron absorption. Most HH patients are homozygous for the…”
Get full text

Sunlight-induced mutagenicity of a common sunscreen ingredient by Knowland, John, McKenzie, Edward A, McHugh, Peter J, Cridland, Nigel A

“…We have tested the mutagenicity of a UV-B sunscreen ingredient called Padimate-O or octyl dimethyl PABA, which, chemically speaking, is identical to an…”
Get full text

Measurement of covalent drug-DNA interactions at the nucleotide level in cells at pharmacologically relevant doses by McGurk, C J, McHugh, P J, Tilby, M J, Grimaldi, K A, Hartley, J A

Get more information

Defects in interstrand cross‐link uncoupling do not account for the extreme sensitivity of ERCC1 and XPF cells to cisplatin by De Silva, Inusha U., McHugh, Peter J., Clingen, Peter H., Hartley, John A.

“…The anticancer drug cisplatin reacts with DNA leading to the formation of interstrand and intrastrand cross‐links that are the critical cytotoxic lesions. In…”
Get full text

Repair of Intermediate Structures Produced at DNA Interstrand Cross-Links in Saccharomyces cerevisiae by McHugh, Peter J., Sones, William R., Hartley, John A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Nonlinear evolution of a thin anodic film by McHugh, J. P., Barkey, D.

“…The formation of pores in anodic aluminium oxide films is treated with a model equation. The model treats the oxide layer as a thin viscous liquid in two…”
Get full text

The role of base excision repair in the repair of DNA adducts formed by a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size by Brooks, N, McHugh, P J, Lee, M, Hartley, J A

“…The role of base excision repair in the repair of alkylation damage produced by a series of sequence specific oligopyrrole-containing analogues of distamycin A…”
Get more information

Characterization of DNA Damage Inflicted by Free Radicals from a Mutagenic Sunscreen Ingredient and Its Location Using an in vitro Genetic Reversion Assay by McHugh, Peter J., Knowland, John

“…We describe an in vitro approach to assessing the potential genotoxicity of illuminated sunscreens. The photomutagenic sunscreen Padimate‐O attacks DNA on…”
Get full text

Schizosaccharomyces pombe Checkpoint Response to DNA Interstrand Cross-Links by Lambert, Sarah, Mason, Sarah J., Barber, Louise J., Hartley, John A., Pearce, Jackie A., Carr, Anthony M., McHugh, Peter J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text