Search Results - "McHugh, Gillian S"

Advancing care for traumatic brain injury: findings from the IMPACT studies and perspectives on future research by Maas, Andrew I R, Prof, Murray, Gordon D, Prof, Roozenbeek, Bob, MD, Lingsma, Hester F, PhD, Butcher, Isabella, PhD, McHugh, Gillian S, PhD, Weir, James, MSc, Lu, Juan, MD, Steyerberg, Ewout W, Prof

“…Summary Research in traumatic brain injury (TBI) is challenging for several reasons; in particular, the heterogeneity between patients regarding causes,…”
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Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics by Steyerberg, Ewout W, Mushkudiani, Nino, Perel, Pablo, Butcher, Isabella, Lu, Juan, McHugh, Gillian S, Murray, Gordon D, Marmarou, Anthony, Roberts, Ian, Habbema, J Dik F, Maas, Andrew I R

“…Traumatic brain injury (TBI) is a leading cause of death and disability. A reliable prediction of outcome on admission is of great clinical relevance. We aimed…”
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Multivariable prognostic analysis in traumatic brain injury: results from the IMPACT study by Murray, Gordon D, Butcher, Isabella, McHugh, Gillian S, Lu, Juan, Mushkudiani, Nino A, Maas, Andrew I R, Marmarou, Anthony, Steyerberg, Ewout W

“…We studied the prognostic value of a wide range of conventional and novel prognostic factors on admission after traumatic brain injury (TBI) using both…”
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Prognostic value of the Glasgow Coma Scale and pupil reactivity in traumatic brain injury assessed pre-hospital and on enrollment: an IMPACT analysis by Marmarou, Anthony, Lu, Juan, Butcher, Isabella, McHugh, Gillian S, Murray, Gordon D, Steyerberg, Ewout W, Mushkudiani, Nino A, Choi, Sung, Maas, Andrew I R

“…We studied the prognostic strength of the individual components of the Glasgow Coma Scale (GCS) and pupil reactivity to Glasgow Outcome Score (GOS) at 6 months…”
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Prognostic value of secondary insults in traumatic brain injury: results from the IMPACT study by McHugh, Gillian S, Engel, Doortje C, Butcher, Isabella, Steyerberg, Ewout W, Lu, Juan, Mushkudiani, Nino, Hernández, Adrián V, Marmarou, Anthony, Maas, Andrew I R, Murray, Gordon D

“…We determined the relationship between secondary insults (hypoxia, hypotension, and hypothermia) occurring prior to or on admission to hospital and 6-month…”
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Prognostic value of computerized tomography scan characteristics in traumatic brain injury: results from the IMPACT study by Maas, Andrew I R, Steyerberg, Ewout W, Butcher, Isabella, Dammers, Ruben, Lu, Juan, Marmarou, Anthony, Mushkudiani, Nino A, McHugh, Gillian S, Murray, Gordon D

“…Computerized tomography (CT) scanning provides an objective assessment of the structural damage to the brain following traumatic brain injury (TBI). We aimed…”
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Prognostic value of demographic characteristics in traumatic brain injury: results from the IMPACT study by Mushkudiani, Nino A, Engel, Doortje C, Steyerberg, Ewout W, Butcher, Isabella, Lu, Juan, Marmarou, Anthony, Slieker, Frans, McHugh, Gillian S, Murray, Gordon D, Maas, Andrew I R

“…Outcome following traumatic brain injury (TBI) is not only dependent on the nature and severity of injury and subsequent treatment, but also on constituent…”
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IMPACT database of traumatic brain injury: design and description by Marmarou, Anthony, Lu, Juan, Butcher, Isabella, McHugh, Gillian S, Mushkudiani, Nino A, Murray, Gordon D, Steyerberg, Ewout W, Maas, Andrew I R

“…The objective of this report is to describe the design and content of the International Mission for Prognosis And Clinical Trial (IMPACT) database of traumatic…”
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Prognostic value of admission laboratory parameters in traumatic brain injury: results from the IMPACT study by Van Beek, Jackelien G M, Mushkudiani, Nino A, Steyerberg, Ewout W, Butcher, Isabella, McHugh, Gillian S, Lu, Juan, Marmarou, Anthony, Murray, Gordon D, Maas, Andrew I R

“…Abnormalities in laboratory parameters are frequent following traumatic brain injury (TBI), but few studies have investigated their predictive value. We aimed…”
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Prediction of outcome after moderate and severe traumatic brain injury: External validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models by Roozenbeek, Bob, Lingsma, Hester F, Lecky, Fiona E, Lu, Juan, Weir, James, Butcher, Isabella, McHugh, Gillian S, Murray, Gordon D, Perel, Pablo, Maas, Andrew I, Steyerberg, Ewout W

“…OBJECTIVE:The International Mission on Prognosis and Analysis of Clinical Trials and Corticoid Randomisation After Significant Head injury prognostic models…”
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Does the extended Glasgow Outcome Scale add value to the conventional Glasgow Outcome Scale? by Weir, James, Steyerberg, Ewout W, Butcher, Isabella, Lu, Juan, Lingsma, Hester F, McHugh, Gillian S, Roozenbeek, Bob, Maas, Andrew I R, Murray, Gordon D

“…The Glasgow Outcome Scale (GOS) is firmly established as the primary outcome measure for use in Phase III trials of interventions in traumatic brain injury…”
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Performance of the Hospital Anxiety and Depression Scale as a screening tool for major depressive disorder in cancer patients by Walker, Jane, Postma, Kirstine, McHugh, Gillian S, Rush, Robert, Coyle, Brian, Strong, Vanessa, Sharpe, Michael

“…Abstract Objectives (1) To assess the overall performance of the Hospital Anxiety and Depression Scale (HADS) as a screening instrument to identify cases of…”
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IMPACT Recommendations for Improving the Design and Analysis of Clinical Trials in Moderate to Severe Traumatic Brain Injury by Maas, Andrew I.R., Steyerberg, Ewout W., Marmarou, Anthony, McHugh, Gillian S., Lingsma, Hester F., Butcher, Isabella, Lu, Juan, Weir, James, Roozenbeek, Bob, Murray, Gordon D.

“…Clinical trials in traumatic brain injury (TBI) pose complex methodological challenges, largely related to the heterogeneity of the population. The…”
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Prognostic value of admission blood pressure in traumatic brain injury: results from the IMPACT study by Butcher, Isabella, Maas, Andrew I R, Lu, Juan, Marmarou, Anthony, Murray, Gordon D, Mushkudiani, Nino A, McHugh, Gillian S, Steyerberg, Ewout W

“…Hypotension following traumatic brain injury (TBI) is recognized as an important secondary insult that is associated with adverse outcome. We aimed to describe…”
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A simulation study evaluating approaches to the analysis of ordinal outcome data in randomized controlled trials in traumatic brain injury: results from the IMPACT Project by McHugh, Gillian S, Butcher, Isabella, Steyerberg, Ewout W, Marmarou, Anthony, Lu, Juan, Lingsma, Hester F, Weir, James, Maas, Andrew I R, Murray, Gordon D

“…Background Clinical trials in traumatic brain injury have a disappointing track record, with a long history of ‘negative’ Phase III trials. One contributor to…”
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Effects of Glasgow Outcome Scale misclassification on traumatic brain injury clinical trials by Lu, Juan, Murray, Gordon D, Steyerberg, Ewout W, Butcher, Isabella, McHugh, Gillian S, Lingsma, Hester, Mushkudiani, Nino, Choi, Sung, Maas, Andrew I R, Marmarou, Anthony

“…The Glasgow Outcome Scale (GOS) is the primary endpoint for efficacy analysis of clinical trials in traumatic brain injury (TBI). Accurate and consistent…”
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Prognostic value of cause of injury in traumatic brain injury: results from the IMPACT study by Butcher, Isabella, McHugh, Gillian S, Lu, Juan, Steyerberg, Ewout W, Hernández, Adrián V, Mushkudiani, Nino, Maas, Andrew I R, Marmarou, Anthony, Murray, Gordon D

“…We aimed to describe and quantify the relationship between cause of injury and final outcome following traumatic brain injury (TBI). Individual patient data (N…”
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Statistical approaches to the univariate prognostic analysis of the IMPACT database on traumatic brain injury by McHugh, Gillian S, Butcher, Isabella, Steyerberg, Ewout W, Lu, Juan, Mushkudiani, Nino, Marmarou, Anthony, Maas, Andrew I R, Murray, Gordon D

“…The univariate prognostic analysis of the IMPACT database on traumatic brain injury (TBI) poses the formidable challenge of how best to summarize a highly…”
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The influence of enrollment criteria on recruitment and outcome distribution in traumatic brain injury studies: results from the impact study by Roozenbeek, Bob, Maas, Andrew I R, Marmarou, Anthony, Butcher, Isabella, Lingsma, Hester F, Lu, Juan, McHugh, Gillian S, Murray, Gordon D, Steyerberg, Ewout W

“…Substantial heterogeneity exists among patients who suffer from traumatic brain injury (TBI). Strict enrollment criteria may diminish heterogeneity in…”
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Baseline characteristics and statistical power in randomized controlled trials: Selection, prognostic targeting, or covariate adjustment? by ROOZENBEEK, Bob, MAAS, Andrew I. R, LINGSMA, Hester F, BUTCHER, Isabella, JUAN LU, MARMAROU, Anthony, MCHUGH, Gillian S, WEIR, James, MURRAY, Gordon D, STEYERBERG, Ewout W

“…Heterogeneity of patients is a common problem in randomized controlled trials (RCTs) in various fields of clinical research. We aimed to investigate the…”
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