Search Results - "McHugh, Brian"

Loss of the integrin-activating transmembrane protein Fam38A (Piezo1) promotes a switch to a reduced integrin-dependent mode of cell migration by McHugh, Brian J, Murdoch, Amanda, Haslett, Christopher, Sethi, Tariq

“…Lung cancer is one of the most common fatal diseases in the developed world. The disease is rarely cured by currently available therapies, with an overall…”
Get full text

The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus by Currie, Silke M, Findlay, Emily Gwyer, McHugh, Brian J, Mackellar, Annie, Man, Tian, Macmillan, Derek, Wang, Hongwei, Fitch, Paul M, Schwarze, Jürgen, Davidson, Donald J

“…Respiratory syncytial virus is a leading cause of lower respiratory tract illness among infants, the elderly and immunocompromised individuals. Currently,…”
Get full text

Blood Neutrophils Are Reprogrammed in Bronchiectasis by Bedi, Pallavi, Davidson, Donald J, McHugh, Brian J, Rossi, Adriano G, Hill, Adam T

“…Excessive neutrophilic airway inflammation is the central feature of bronchiectasis, but little is known about neutrophils in bronchiectasis. To assess blood…”
Get full text

Short- and Long-Term Antibiotic Treatment Reduces Airway and Systemic Inflammation in Non―Cystic Fibrosis Bronchiectasis by CHALMERS, James D, SMITH, Maeve P, MCHUGH, Brian J, DOHERTY, Cathy, GOVAN, John R, HILL, Adam T

“…The vicious cycle hypothesis of bronchiectasis argues that bacterial colonization leads to airway inflammation and progressive lung damage. The logical…”
Get full text

An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade by Vuong, Lynda, Kouverianou, Eleni, Rooney, Claire M, McHugh, Brian J, Howie, Sarah E M, Gregory, Christopher D, Forbes, Stuart J, Henderson, Neil C, Zetterberg, Fredrik R, Nilsson, Ulf J, Leffler, Hakon, Ford, Paul, Pedersen, Anders, Gravelle, Lise, Tantawi, Susan, Schambye, Hans, Sethi, Tariq, MacKinnon, Alison C

“…A combination therapy approach is required to improve tumor immune infiltration and patient response to immune checkpoint inhibitors that target negative…”
Get full text

The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation by Smith, Katie J, Minns, Danielle, McHugh, Brian J, Holloway, Rebecca K, O'Connor, Richard, Williams, Anna, Melrose, Lauren, McPherson, Rhoanne, Miron, Veronique E, Davidson, Donald J, Gwyer Findlay, Emily

“…Multiple sclerosis (MS) is a highly prevalent demyelinating autoimmune condition; the mechanisms regulating its severity and progression are unclear. The…”
Get full text

Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa by McHugh, Brian J, Wang, Rongling, Li, Hsin-Ni, Beaumont, Paula E, Kells, Rebekah, Stevens, Holly, Young, Lisa, Rossi, Adriano G, Gray, Robert D, Dorin, Julia R, Gwyer Findlay, Emily L, Brough, David, Davidson, Donald J

“…Pulmonary infections are a major global cause of morbidity, exacerbated by an increasing threat from antibiotic-resistant pathogens. In this context,…”
Get full text

Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum by McHugh, Brian J, Buttery, Robert, Lad, Yatish, Banks, Stephen, Haslett, Christopher, Sethi, Tariq

“…The integrin family of heterodimeric cell-surface receptors are fundamental in cell-cell and cell-matrix adhesion. Changes to either integrin-ligand affinity…”
Get full text

Microbial Host Interactions and Impaired Wound Healing in Mice and Humans: Defining a Role for BD14 and NOD2 by Williams, Helen, Campbell, Laura, Crompton, Rachel A., Singh, Gurdeep, McHugh, Brian J., Davidson, Donald J., McBain, Andrew J., Cruickshank, Sheena M., Hardman, Matthew J.

“…Chronic wounds cause significant patient morbidity and mortality. A key factor in their etiology is microbial infection, yet skin host-microbiota interactions…”
Get full text

Vitamin-D deficiency is associated with chronic bacterial colonisation and disease severity in bronchiectasis by Chalmers, James D, McHugh, Brian J, Docherty, Catherine, Govan, John R W, Hill, Adam T

“…Vitamin-D deficiency has been linked to an increased risk of respiratory infections. The objective of this study was to determine the frequency and clinical…”
Get more information

NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease by Ryan, Eilise M, Sadiku, Pranvera, Coelho, Patricia, Watts, Emily R, Zhang, Ailiang, Howden, Andrew J M, Sanchez-Garcia, Manuel A, Bewley, Martin, Cole, Joby, McHugh, Brian J, Vermaelen, Wesley, Ghesquiere, Bart, Carmeliet, Peter, Rodriguez Blanco, Giovanny, Von Kriegsheim, Alex, Sanchez, Yolanda, Rumsey, William, Callahan, James F, Cooper, George, Parkinson, Nicholas, Baillie, Kenneth, Cantrell, Doreen A, McCafferty, John, Choudhury, Gourab, Singh, Dave, Dockrell, David H, Whyte, Moira K B, Walmsley, Sarah R

“…Chronic obstructive pulmonary disease (COPD) is a disease characterized by persistent airway inflammation and disordered macrophage function. The extent to…”
Get full text

A mechanistic evaluation of human beta defensin 2 mediated protection of human skin barrier in vitro by Shelley, Jennifer R., McHugh, Brian J., Wills, Jimi, Dorin, Julia R., Weller, Richard, Clarke, David J., Davidson, Donald J.

“…The human skin barrier, a biological imperative, is impaired in inflammatory skin diseases such as atopic dermatitis (AD). Staphylococcus aureus is associated…”
Get full text

Human cathelicidin production by the cervix by Frew, Lorraine, Makieva, Sofia, McKinlay, Andrew T M, McHugh, Brian J, Doust, Ann, Norman, Jane E, Davidson, Donald J, Stock, Sarah J

“…hCAP18/LL-37 is the sole human cathelicidin; a family of host defence peptides with key roles in innate host defence. hCAP18/LL-37 is expressed primarily by…”
Get full text

Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation by Humphries, Duncan C., Mills, Ross, Boz, Cecilia, McHugh, Brian J., Hirani, Nikhil, Rossi, Adriano G., Pedersen, Anders, Schambye, Hans T., Slack, Robert J., Leffler, Hakon, Nilsson, Ulf J., Wang, Wei, Sethi, Tariq, Mackinnon, Alison C.

“…Rationale: Galectin-3 (Gal-3) drives fibrosis during chronic lung injury, however, its role in acute lung injury (ALI) remains unknown. Effective…”
Get full text

Mannose-binding lectin deficiency and disease severity in non-cystic fibrosis bronchiectasis: a prospective study by Chalmers, James D, Dr, McHugh, Brian J, PhD, Doherty, Catherine, PhD, Smith, Maeve P, MD, Govan, John R, Prof, Kilpatrick, David C, PhD, Hill, Adam T, MD

“…Summary Background Mannose-binding lectin (MBL) is a key component of innate immunity. MBL deficiency is common (10–30% of the general population depending on…”
Get full text

IL-1β–Induced Protection of Keratinocytes against Staphylococcus aureus-Secreted Proteases Is Mediated by Human β-Defensin 2 by Wang, Bingjie, McHugh, Brian J., Qureshi, Ayub, Campopiano, Dominic J., Clarke, David J., Fitzgerald, J. Ross, Dorin, Julia R., Weller, Richard, Davidson, Donald J.

“…Atopic dermatitis (AD) is a common chronic inflammatory skin disease that results in significant morbidity. A hallmark of AD is disruption of the critical…”
Get full text

Change in somatosensory evoked potentials detect an acute arterial stent occlusion in lower extremity during spinal surgery: Case report by Palumbo, Salvatore J., Francfort, John W., Kakoulides, George V., McHugh, Brian J., McIntyre, Michael F.

“…The authors report a case in which an acute thrombosis of a pre-existing arterial stent occurs in a patient’s lower extremity during a lumbar spinal fusion…”
Get full text

A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages by Rodriguez-Rios, Maria, McHugh, Brian J., Liang, Zhengqi, Megia-Fernandez, Alicia, Lilienkampf, Annamaria, Dockrell, David, Bradley, Mark

“…Cathepsin D is a protease that is an effector in the immune response of macrophages, yet to date, only a limited number of probes have been developed for its…”
Get full text

Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy by Findlay, Emily Gwyer, Currie, Andrew J., Zhang, Ailiang, Ovciarikova, Jana, Young, Lisa, Stevens, Holly, McHugh, Brian J., Canel, Marta, Gray, Mohini, Milling, Simon W.F., Campbell, John D.M., Savill, John, Serrels, Alan, Davidson, Donald J.

“…Immunization of patients with autologous, ex vivo matured dendritic cell (DC) preparations, in order to prime antitumor T-cell responses, is the focus of…”
Get full text

Cathelicidin host defence peptide augments clearance of pulmonary Pseudomonas aeruginosa infection by its influence on neutrophil function in vivo by Beaumont, Paula E, McHugh, Brian, Gwyer Findlay, Emily, Mackellar, Annie, Mackenzie, Karen J, Gallo, Richard L, Govan, John R W, Simpson, A John, Davidson, Donald J

“…Cathelicidins are multifunctional cationic host-defence peptides (CHDP; also known as antimicrobial peptides) and an important component of innate host defence…”
Get full text