Search Results - "McHale, Noel G."

Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal by Fedigan, Stephen, Bradley, Eamonn, Webb, Timothy, Large, Roddy J., Hollywood, Mark A., Thornbury, Keith D., McHale, Noel G., Sergeant, Gerard P.

“…Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit Ca 2+ -activated Cl − currents ( I ClCa ) that are important for the development of…”
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Muscarinic Receptor Induced Contractions of the Detrusor are Mediated by Activation of TRPC4 Channels by Griffin, Caoimhin S, Bradley, Eamonn, Dudem, Srikanth, Hollywood, Mark A, McHale, Noel G, Thornbury, Keith D, Sergeant, Gerard P

“…Purpose Muscarinic receptor mediated contractions of the detrusor rely on Ca2+ influx through voltage-gated Ca2+ channels but to our knowledge the mechanism…”
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The role of Ca2+ influx in spontaneous Ca2+ wave propagation in interstitial cells of Cajal from the rabbit urethra by Drumm, Bernard T., Large, Roddy J., Hollywood, Mark A., Thornbury, Keith D., Baker, Salah A., Harvey, Brian J., McHale, Noel G., Sergeant, Gerard P.

“…Key points Tonic contractions of rabbit urethra are associated with spontaneous electrical slow waves that are thought to originate in pacemaker cells termed…”
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Molecular mechanisms underlying the effect of the novel BK channel opener GoSlo: Involvement of the S4/S5 linker and the S6 segment by Webb, Timothy I., Kshatri, Aravind Singh, Large, Roddy J., Akande, Adebola Morayo, Roy, Subhrangsu, Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

“…Significance Large-conductance Ca ²⁺-activated K ⁺ (BK) calcium-activated potassium channels alter the excitability of a wide variety of cells including nerves…”
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ATP Evokes Inward Currents in Corpus Cavernosum Myocytes by Doyle, Claire, Sergeant, Gerard P., Hollywood, Mark A., McHale, Noel G., Thornbury, Keith D.

“…Although adenosine triphosphate (ATP) has often been reported to relax the corpus cavernosum, this may be mediated by indirect effects, such as release of…”
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Role of mitochondria in modulation of spontaneous Ca2+ waves in freshly dispersed interstitial cells of Cajal from the rabbit urethra by Sergeant, Gerard P., Bradley, Eamonn, Thornbury, Keith D., McHale, Noel G., Hollywood, Mark A.

“…Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit pacemaker activity that results from spontaneous Ca 2+ waves. The purpose of this…”
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Spontaneous Ca2+ Waves in Rabbit Corpus Cavernosum: Modulation by Nitric Oxide and cGMP by Sergeant, Gerard P., Craven, Michael, Hollywood, Mark A., McHale, Noel G., Thornbury, Keith D.

“…Detumescent tone and subsequent relaxation by nitric oxide (NO) are essential processes that determine the erectile state of the penis. Despite this, the…”
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Platelet‐derived growth factor receptor‐α cells in mouse urinary bladder: a new class of interstitial cells by Koh, Byoung H., Roy, Rishiparna, Hollywood, Mark A., Thornbury, Keith D., McHale, Noel G., Sergeant, Gerard P., Hatton, William J., Ward, Sean M., Sanders, Kenton M., Koh, Sang Don

“…Specific classes of interstitial cells exist in visceral organs and have been implicated in several physiological functions including pacemaking and mediators…”
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The role of Ca(2+) influx in spontaneous Ca(2+) wave propagation in interstitial cells of Cajal from the rabbit urethra by Drumm, Bernard T, Large, Roddy J, Hollywood, Mark A, Thornbury, Keith D, Baker, Salah A, Harvey, Brian J, McHale, Noel G, Sergeant, Gerard P

“…Tonic contractions of rabbit urethra are associated with spontaneous electrical slow waves that are thought to originate in pacemaker cells termed interstitial…”
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β3‐adrenoceptor agonists inhibit carbachol‐evoked Ca2+ oscillations in murine detrusor myocytes by Griffin, Caoimhin S., Bradley, Eamonn, Hollywood, Mark A., McHale, Noel G., Thornbury, Keith D., Sergeant, Gerard P.

“…Objective To test if carbachol (CCh)‐evoked Ca2+ oscillations in freshly isolated murine detrusor myocytes are affected by β3‐adrenoceptor (β‐AR) modulators…”
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β3-adrenoceptor agonists inhibit carbachol-evoked Ca 2+ oscillations in murine detrusor myocytes by Griffin, Caoimhin S, Bradley, Eamonn, Hollywood, Mark A, McHale, Noel G, Thornbury, Keith D, Sergeant, Gerard P

“…To test if carbachol (CCh)-evoked Ca oscillations in freshly isolated murine detrusor myocytes are affected by β3-adrenoceptor (β-AR) modulators. Isometric…”
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Pharmacological characterization of TMEM16A currents by Bradley, Eamonn, Fedigan, Stephen, Webb, Timothy, Hollywood, Mark A, Thornbury, Keith D, McHale, Noel G, Sergeant, Gerard P

“…Recent studies have shown that transmembrane protein 16 A (TMEM16A) is a subunit of calcium-activated chloride channels (CACCs). Pharmacological agents have…”
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The role of Ca 2+ -activated Cl - current in tone generation in the rabbit corpus cavernosum by Hannigan, Karen I, Griffin, Caoimhin S, Large, Roddy J, Sergeant, Gerard P, Hollywood, Mark A, McHale, Noel G, Thornbury, Keith D

“…Rabbit corpus cavernosum smooth muscle (RCCSM) cells express ion channels that produce Ca -activated Cl ( ) current, but low sensitivity to conventional…”
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The role of cAMP dependent protein kinase in modulating spontaneous intracellular Ca2+ waves in interstitial cells of Cajal from the rabbit urethra by Drumm, Bernard T, Sergeant, Gerard P, Hollywood, Mark A, Thornbury, Keith D, McHale, Noel G, Harvey, Brian J

“…Graphical abstract…”
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Development of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels by Roy, Subhrangsu, Large, Roddy J., Akande, Adebola Morayo, Kshatri, Aravind, Webb, Tim I., Domene, Carmen, Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

“…We have designed, synthesised and characterised the effects of a number of novel anthraquinone derivatives and assessed their effects on large conductance,…”
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Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists by Kyle, Barry D, Bradley, Eamonn, Large, Roddy, Sergeant, Gerard P, McHale, Noel G, Thornbury, Keith D, Hollywood, Mark A

“…We used the perforated patch-clamp technique at 37°C to investigate the mechanisms underlying the activation of a transient large-conductance K(+) (tBK)…”
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Differential efficacy of GoSlo-SR compounds on BKα and BKαγ1-4 channels by Kshatri, Aravind S., Li, Qin, Yan, Jiusheng, Large, Roddy J., Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

“…Large conductance, voltage and Ca 2+ activated K + channels (BK channels) are abundantly expressed throughout the body and are important regulators of smooth…”
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Structure-Activity Relationships of a Novel Group of Large-Conductance Ca2+-Activated K+ (BK) Channel Modulators: The GoSlo-SR Family by Roy, Subhrangsu, Morayo Akande, Adebola, Large, Roddy J., Webb, Tim I., Camarasu, Costin, Sergeant, Gerard P., McHale, Noel G., Thornbury, Keith D., Hollywood, Mark A.

“…Opening up ion channels: We synthesised a series of anthraquinone analogues, called the GoSlo‐SR family. Their effects on bladder smooth muscle BK channels…”
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Structure-activity relationships of a novel group of large-conductance Ca(2+)-activated K(+) (BK) channel modulators: the GoSlo-SR family by Roy, Subhrangsu, Morayo Akande, Adebola, Large, Roddy J, Webb, Tim I, Camarasu, Costin, Sergeant, Gerard P, McHale, Noel G, Thornbury, Keith D, Hollywood, Mark A

“…Opening up ion channels: We synthesised a series of anthraquinone analogues, called the GoSlo-SR family. Their effects on bladder smooth muscle BK channels…”
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P2X receptor currents in smooth muscle cells contribute to nerve mediated contractions of rabbit urethral smooth muscle by Bradley, Eamonn, Kadima, Sonia, Kyle, Barry, Hollywood, Mark A, Thornbury, Keith D, McHale, Noel G, Sergeant, Gerard P

“…Adenosine triphosphate is capable of relaxing and contracting urethral smooth muscle. The mechanisms responsible for the relaxing effects of adenosine…”
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