Search Results - "McGuire, John J."

Design and Synthesis of Classical and Nonclassical 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates by Gangjee, Aleem, Zeng, Yibin, Talreja, Tina, McGuire, John J, Kisliuk, Roy L, Queener, Sherry F

“…The classical antifolate N-{4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoyl}-l-glutamic acid (2) and 15 nonclassical analogues (3−17)…”
Get full text

Characterization and Functions of Protease-Activated Receptor 2 in Obesity, Diabetes, and Metabolic Syndrome: A Systematic Review by Kagota, Satomi, McGuire, John J., Maruyama, Kana

“…Proteinase-activated receptor 2 (PAR2) is a cell surface receptor activated by serine proteinases or specific synthetic compounds. Interest in PAR2 as a…”
Get full text

Perivascular Adipose Tissue-Enhanced Vasodilation in Metabolic Syndrome Rats by Apelin and N -Acetyl⁻l-Cysteine-Sensitive Factor(s) by Kagota, Satomi, Maruyama-Fumoto, Kana, Iwata, Saki, Shimari, Miho, Koyanagi, Shiori, Shiokawa, Yayoi, McGuire, John J, Shinozuka, Kazumasa

“…Perivascular adipose tissue (PVAT) can regulate vascular tone. In mesenteric arteries of SHRSP.Z- /IzmDmcr rats (SHRSP.ZF) with metabolic syndrome, vascular…”
Get full text

Preserved arterial vasodilatation via endothelial protease‐activated receptor‐2 in obese type 2 diabetic mice by Kagota, Satomi, Chia, Elizabeth, McGuire, John J

“…BACKGROUND AND PURPOSE In non‐obese diabetic animals, protease‐activated receptor‐2 (PAR2) agonists are more effective vasodilators, which is attributed to…”
Get full text

Characterization of Endothelium-Dependent Relaxation in the Saphenous Artery and Its Caudal Branches in Young and Old Adult Sprague Dawley Rats by Wang, Andrea N., Fraser, Graham M., McGuire, John J.

“…Ageing is associated with reduced endothelium-derived nitric oxide (NO) production in the femoral artery of Sprague Dawley (SD) rats. In the current study, we…”
Get full text

Modulation of Vasomotor Function by Perivascular Adipose Tissue of Renal Artery Depends on Severity of Arterial Dysfunction to Nitric Oxide and Severity of Metabolic Parameters by Kagota, Satomi, Futokoro, Risa, McGuire, John J., Maruyama-Fumoto, Kana, Shinozuka, Kazumasa

“…Perivascular adipose tissue (PVAT) enhances vascular relaxation of mesenteric arteries in SHRSP.Z-Leprfa/IzmDmcr rats (SPZF), a metabolic syndrome model. We…”
Get full text

Progression of Time-Dependent Changes to the Mechanisms of Vasodilation by Protease-Activated Receptor 2 in Metabolic Syndrome by Maruyama, Kana, McGuire, John J., Kagota, Satomi

“…Protease-activated receptor 2 (PAR2) is a G protein-coupled receptor activated by serine proteases released from tissues or by synthetic peptide ligands…”
Get full text

Age-related changes to vascular protease-activated receptor 2 in metabolic syndrome: a relationship between oxidative stress, receptor expression, and endothelium-dependent vasodilation by Maruyama, Kana, Kagota, Satomi, McGuire, John J, Wakuda, Hirokazu, Yoshikawa, Noriko, Nakamura, Kazuki, Shinozuka, Kazumasa

“…Protease-activated receptor 2 (PAR2) is expressed in vascular endothelium. Nitric oxide (NO) - cyclic GMP-mediated vasodilation in response to…”
Get more information

Cardiac expression of ryanodine receptor subtype 3; a strategic component in the intracellular Ca2+ release system of Purkinje fibers in large mammalian heart by Daniels, Rebecca E., Haq, Kazi T., Miller, Lawson S., Chia, Elizabeth W., Miura, Masahito, Sorrentino, Vincenzo, McGuire, John J., Stuyvers, Bruno D.

“…Three distinct Ca2+ release channels were identified in dog P-cells: the ryanodine receptor subtype 2 (RyR2) was detected throughout the cell, while the…”
Get full text

Time-Dependent Differences in the Influence of Perivascular Adipose Tissue on Vasomotor Functions in Metabolic Syndrome by Kagota, Satomi, Iwata, Saki, Maruyama, Kana, McGuire, John J, Shinozuka, Kazumasa

“…Metabolic syndrome (MetS) facilitates the development of cardiovascular disease due to atherosclerosis, which is accelerated by defects of the vascular…”
Get more information

Attenuated vasodilator effectiveness of protease-activated receptor 2 agonist in heterozygous par2 knockout mice by Hennessey, John C, McGuire, John J

“…Studies of homozygous PAR2 gene knockout mice have described a mix of phenotypic effects in vitro and in vivo. However, there have been few studies of PAR2…”
Get full text

2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist by McGuire, John J, Saifeddine, Mahmoud, Triggle, Chris R, Sun, Kimberly, Hollenberg, Morley D

“…A peptide corresponding to a proteinase-activated receptor 2 (PAR(2))-activating peptide with an N-terminal furoyl group modification, 2-furoyl-LIGRLO-NH(2),…”
Get more information

Enhanced Nitric Oxide Synthase Activation via Protease-Activated Receptor 2 Is Involved in the Preserved Vasodilation in Aortas from Metabolic Syndrome Rats by Maruyama, Kana, Kagota, Satomi, McGuire, John J, Wakuda, Hirokazu, Yoshikawa, Noriko, Nakamura, Kazuki, Shinozuka, Kazumasa

“…Endothelium-dependent vasodilation via protease-activated receptor 2 (PAR2) is preserved in mesenteric arteries from SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP.ZF)…”
Get more information

Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase as Antitumor Agents:  Design, Synthesis, and Biological Evaluation of Classical and Nonclassical Pyrrolo[2,3-d]pyrimidine Antifolates by Gangjee, Aleem, Jain, Hiteshkumar D, Phan, Jaclyn, Lin, Xin, Song, Xiaohong, McGuire, John J, Kisliuk, Roy L

“…We designed and synthesized a classical analogue N-[4-[(2-amino-6-ethyl-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)thio]benzoyl]-l-glutamic acid (4) and…”
Get full text

Zucker Diabetic‐Sprague Dawley (ZDSD) rat: Type 2 diabetes translational research model by Wang, Andrea N., Carlos, Joselia, Fraser, Graham M., McGuire, John J.

“…New Findings What is the topic of this review? The Zucker Diabetic‐Sprague Dawley (ZDSD) rat is in the early adoption phase of use by researchers in the fields…”
Get full text

Endothelium dysfunction in hind limb arteries of male Zucker Diabetic-Sprague Dawley rats by Wang, Andrea N., Carlos, Joselia, Singh, Krishna K., Fraser, Graham M., McGuire, John J.

“…[Display omitted] Endothelium dysfunction produces peripheral vascular disease comorbidities in type 2 diabetes, including hypertension, and critical limb…”
Get full text

Synthesis of N-{4-[(2,4-Diamino-5-methyl-4,7-dihydro-3H- pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-l-glutamic Acid and N-{4-[(2-Amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin- 6-yl)thio]benzoyl}-l-glutamic Acid as Dual Inhibitors of Dihydrofolate Reductase and Thymidylate Synthase and as Potential Antitumor Agents by Gangjee, Aleem, Lin, Xin, Kisliuk, Roy L, McGuire, John J

“…Two novel classical antifolates N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-l-glutamic acid 3 and…”
Get full text

Angiotensin II Type 1 Receptor Antagonist Azilsartan Restores Vascular Reactivity Through a Perivascular Adipose Tissue-Independent Mechanism in Rats with Metabolic Syndrome by Kagota, Satomi, Maruyama-Fumoto, Kana, Shimari, Miho, McGuire, John J., Shinozuka, Kazumasa

“…Purpose Perivascular adipose tissues (PVAT) are involved in the regulation of vascular tone. In mesenteric arteries, the compensatory vasodilatory effects of…”
Get full text

A Sodium Glucose Cotransporter 2 Inhibitor Fails to Improve Perivascular Adipose Tissue-Mediated Modulation of Vasodilation and Cardiac Function in Rats With Metabolic Syndrome by Kagota, Satomi, Maruyama-Fumoto, Kana, McGuire, John J, Shinozuka, Kazumasa

“…Arterial perivascular adipose tissue (PVAT) can elicit vasodilator signals complementary to those elicited by the endothelium in SHRSP.Z- /IzmDmcr (SHRSP.ZF)…”
Get more information

Loss of fatty acid binding protein 3 ameliorates lipopolysaccharide-induced inflammation and endothelial dysfunction by Nguyen, Hien C., Bu, Shuhan, Nikfarjam, Sepideh, Rasheed, Berk, Michels, David C.R., Singh, Aman, Singh, Shweta, Marszal, Caroline, McGuire, John J., Feng, Qingping, Frisbee, Jefferson C., Qadura, Mohammad, Singh, Krishna K.

“…Circulating fatty acid–binding protein 3 (FABP3) is an effective biomarker of myocardial injury and peripheral artery disease (PAD). The endothelium, which…”
Get full text