Search Results - "McGuinness, Bernadette"

Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia by McGuinness, Bernadette, Todd, Stephen, Passmore, Peter, Bullock, Roger

“…This is an update of a previous review (McGuinness 2006).Hypertension and cognitive impairment are prevalent in older people. Hypertension is a direct risk…”
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Effect of dietary interventions in mild cognitive impairment: a systematic review by McGrattan, Andrea M., McEvoy, Claire T., McGuinness, Bernadette, McKinley, Michelle C., Woodside, Jayne V.

“…Diet has been investigated in relation to its ability to promote cognitive function. However, evidence is currently limited and has rarely been systematically…”
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Pharmacological treatment of hypertension in people without prior cerebrovascular disease for the prevention of cognitive impairment and dementia by Cunningham, Emma L, Todd, Stephen A, Passmore, Peter, Bullock, Roger, McGuinness, Bernadette

“…This is an update of a Cochrane Review first published in 2006 (McGuinness 2006), and previously updated in 2009 (McGuinness 2009). Hypertension is a risk…”
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Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease by Graham, Stewart F, Chevallier, Olivier P, Elliott, Christopher T, Hölscher, Christian, Johnston, Janet, McGuinness, Bernadette, Kehoe, Patrick G, Passmore, Anthony Peter, Green, Brian D

“…This study combined high resolution mass spectrometry (HRMS), advanced chemometrics and pathway enrichment analysis to analyse the blood metabolome of patients…”
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Carers' experiences and perspectives of the use of anticholinergic medications in people living with dementia: Analysis of an online discussion forum by Shawaqfeh, Bara'a, Hughes, Carmel M., McGuinness, Bernadette, Barry, Heather E.

“…Introduction There is concern about the use of anticholinergic medications in people living with dementia (PLWD). Such medicines may increase cognitive decline…”
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Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome by Pan, Xiaobei, Nasaruddin, Muhammad Bin, Elliott, Christopher T, McGuinness, Bernadette, Passmore, Anthony P, Kehoe, Patrick G, Hölscher, Christian, McClean, Paula L, Graham, Stewart F, Green, Brian D

“…Abstract The pathogenesis of Alzheimer's disease (AD) is complex involving multiple contributing factors. The extent to which AD pathology affects the…”
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Prevalence of cognitive impairment in patients with rheumatoid arthritis: a cross sectional study by McDowell, Bethany, Marr, Calum, Holmes, Clive, Edwards, Christopher J, Cardwell, Christopher, McHenry, Michelle, Meenagh, Gary, McGuinness, Bernadette

“…To explore the role of chronic inflammation in rheumatoid arthritis (RA) on cognition. Six hundred sixty-one men and women aged ≥55 years who fulfilled the…”
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Investigating the prevalence of cognitive impairment and dementia in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA): the Harmonised Cognitive Assessment Protocol (HCAP) cross-sectional substudy by O'Hara, Leeanne, Neville, Charlotte, Marr, Calum, McAlinden, Michael, Kee, Frank, Weir, David, McGuinness, Bernadette

“…IntroductionThe Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA) study is the largest study of ageing in Northern Ireland (NI). The…”
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Multi-Kernel Learning with Dartel Improves Combined MRI-PET Classification of Alzheimer's Disease in AIBL Data: Group and Individual Analyses by Youssofzadeh, Vahab, McGuinness, Bernadette, Maguire, Liam P, Wong-Lin, KongFatt

“…Magnetic resonance imaging (MRI) and positron emission tomography (PET) are neuroimaging modalities typically used for evaluating brain changes in Alzheimer's…”
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The impact of dental status on perceived ability to eat certain foods and nutrient intakes in older adults: cross-sectional analysis of the UK National Diet and Nutrition Survey 2008-2014 by Watson, Sinead, McGowan, Laura, McCrum, Leigh-Ann, Cardwell, Christopher R, McGuinness, Bernadette, Moore, Ciaran, Woodside, Jayne V, McKenna, Gerald

“…Many factors determine dietary intake in older adults, including physical health, psychological well-being and socio-economic status. Dental status may also be…”
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Cohort profile: DNA methylation in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA) – recruitment and participant characteristics by Potter, Claire, Hill, Claire, Smyth, Laura J, Neville, Charlotte, Scott, Angela, Kee, Frank, McGuinness, Bernadette, McKnight, Amy

“…PurposeEpigenetic modifications including DNA methylation (DNAm) are proposed mechanisms by which social or environmental exposures may influence health and…”
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Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA): health assessment protocol, participant profile and patterns of participation by Neville, Charlotte E, Young, Ian S, Kee, Frank, Hogg, Ruth E, Scott, Angela, Burns, Frances, Woodside, Jayne V, McGuinness, Bernadette

“…The Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA) is a prospective, longitudinal study of a representative cohort of older adults…”
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Lipid Profiling of Alzheimer's Disease Brain Highlights Enrichment in Glycerol(phospho)lipid, and Sphingolipid Metabolism by Akyol, Sumeyya, Ugur, Zafer, Yilmaz, Ali, Ustun, Ilyas, Gorti, Santosh Kapil Kumar, Oh, Kyungjoon, McGuinness, Bernadette, Passmore, Peter, Kehoe, Patrick G, Maddens, Michael E, Green, Brian D, Graham, Stewart F

“…Alzheimer's disease (AD) is reported to be closely linked with abnormal lipid metabolism. To gain a more comprehensive understanding of what causes AD and its…”
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An investigation into DNA methylation patterns associated with risk preference in older individuals by Smyth, Laura J., Cruise, Sharon M., Tang, Jianjun, Young, Ian, McGuinness, Bernadette, Kee, Frank, McKnight, Amy Jayne

“…Risk preference is a complex trait governed by psycho-social, environmental and genetic determinants. We aimed to examine how an individual's risk preference…”
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Metabolomic Profiling of Bile Acids in Clinical and Experimental Samples of Alzheimer's Disease by Pan, Xiaobei, Elliott, Christopher T, McGuinness, Bernadette, Passmore, Peter, Kehoe, Patrick G, Hölscher, Christian, McClean, Paula L, Graham, Stewart F, Green, Brian D

“…Certain endogenous bile acids have been proposed as potential therapies for ameliorating Alzheimer's disease (AD) but their role, if any, in the…”
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Observational cohort study examining apolipoprotein E status and preoperative neuropsychological performance as predictors of post-operative delirium in an older elective arthroplasty population by Cunningham, Emma Louise, Mawhinney, Tim, Beverland, David, O'Brien, Seamus, McAuley, Daniel F, Cairns, Rebecca, Passmore, Peter, McGuinness, Bernadette

“…delirium following surgery is common and is associated with negative outcomes. Preoperative cognitive impairment has been shown to be a risk factor for…”
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Shaping a data-driven era in dementia care pathway through computational neurology approaches by Wong-Lin, KongFatt, McClean, Paula L, McCombe, Niamh, Kaur, Daman, Sanchez-Bornot, Jose M, Gillespie, Paddy, Todd, Stephen, Finn, David P, Joshi, Alok, Kane, Joseph, McGuinness, Bernadette

“…Dementia is caused by a variety of neurodegenerative diseases and is associated with a decline in memory and other cognitive abilities, while inflicting an…”
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Inflammation and anti-inflammatory strategies for Alzheimer's disease--a mini-review by McNaull, Benjamin Brian Alexander, Todd, Stephen, McGuinness, Bernadette, Passmore, Anthony Peter

“…Until recently, the central nervous system (CNS) has been thought to be an immune privileged organ. However, it is now understood that neuroinflammation is…”
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Establishing Healthy Eating 'Habits': A Pilot Randomised Controlled Trial of a Habit-Based Dietary Intervention following Oral Rehabilitation for Older Adults by Watson, Sinead, McCrum, Leigh-Ann, McGuinness, Bernadette, Cardwell, Christopher, Clarke, Mike, Woodside, Jayne V, McKenna, Gerry, McGowan, Laura

“…An ageing population presents significant nutritional challenges, particularly for partially dentate adults. This two-armed pilot randomised controlled trial…”
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Feasibility of Repeated Assessment of Cognitive Function in Older Adults Using a Wireless, Mobile, Dry-EEG Headset and Tablet-Based Games by McWilliams, Esther C., Barbey, Florentine M., Dyer, John F., Islam, Md Nurul, McGuinness, Bernadette, Murphy, Brian, Nolan, Hugh, Passmore, Peter, Rueda-Delgado, Laura M., Buick, Alison R.

“…Access to affordable, objective and scalable biomarkers of brain function is needed to transform the healthcare burden of neuropsychiatric and…”
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