Search Results - "McGuffin, P"

The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update by Uher, R, McGuffin, P

“…An updated review of 34 human observational studies indicates that the length polymorphism of the serotonin transporter gene moderates the effect of…”
Get full text

Machine learning, statistical learning and the future of biological research in psychiatry by Iniesta, R, Stahl, D, McGuffin, P

“…Psychiatric research has entered the age of 'Big Data'. Datasets now routinely involve thousands of heterogeneous variables, including clinical, neuroimaging,…”
Get more information

The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis by Uher, R, McGuffin, P

“…Gene–environmental interaction (G × E) between a common functional polymorphism in the promoter region of the serotonin transporter gene ( 5-HTT) and…”
Get full text

The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia by Green, E K, Grozeva, D, Jones, I, Jones, L, Kirov, G, Caesar, S, Gordon-Smith, K, Fraser, C, Forty, L, Russell, E, Hamshere, M L, Moskvina, V, Nikolov, I, Farmer, A, McGuffin, P, Holmans, P A, Owen, M J, O'Donovan, M C, Craddock, N

“…Molecular genetic analysis offers opportunities to advance our understanding of the nosological relationship between psychiatric diagnostic categories in…”
Get full text

The current state of play on the molecular genetics of depression by Cohen-Woods, S, Craig, I W, McGuffin, P

“…It has been well established that both genes and non-shared environment contribute substantially to the underlying aetiology of major depressive disorder…”
Get more information

Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms by Uher, R, Perlis, R H, Henigsberg, N, Zobel, A, Rietschel, M, Mors, O, Hauser, J, Dernovsek, M Z, Souery, D, Bajs, M, Maier, W, Aitchison, K J, Farmer, A, McGuffin, P

“…Symptom dimensions have not yet been comprehensively tested as predictors of the substantial heterogeneity in outcomes of antidepressant treatment in major…”
Get more information

Polygenic interactions with environmental adversity in the aetiology of major depressive disorder by Mullins, N, Power, R A, Fisher, H L, Hanscombe, K B, Euesden, J, Iniesta, R, Levinson, D F, Weissman, M M, Potash, J B, Shi, J, Uher, R, Cohen-Woods, S, Rivera, M, Jones, L, Jones, I, Craddock, N, Owen, M J, Korszun, A, Craig, I W, Farmer, A E, McGuffin, P, Breen, G, Lewis, C M

“…Major depressive disorder (MDD) is a common and disabling condition with well-established heritability and environmental risk factors. Gene-environment…”
Get more information

Fecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings by Power, Robert A, Kyaga, Simon, Uher, Rudolf, MacCabe, James H, Långström, Niklas, Landen, Mikael, McGuffin, Peter, Lewis, Cathryn M, Lichtenstein, Paul, Svensson, Anna C

“…It is unknown how genetic variants conferring liability to psychiatric disorders survive in the population despite strong negative selection. However, this is…”
Get more information

Reliability and Comparability of Psychosis Patients' Retrospective Reports of Childhood Abuse by FISHER, Helen L, CRAIG, Thomas K, MURRAY, Robin M, LEFF, Julian, MORGAN, Craig, FEARON, Paul, MORGAN, Kevin, DAZZAN, Paola, LAPPIN, Julia, HUTCHINSON, Gerard, DOODY, Gillian A, JONES, Peter B, MCGUFFIN, Peter

“…An increasing number of studies are demonstrating an association between childhood abuse and psychosis. However, the majority of these rely on retrospective…”
Get full text

Genetic and other risk factors for suicidal ideation and the relationship with depression by Dutta, R, Ball, H A, Siribaddana, S H, Sumathipala, A, Samaraweera, S, McGuffin, P, Hotopf, M

“…There is a genetic contribution to the risk of suicide, but sparse prior research on the genetics of suicidal ideation. Active and passive suicidal ideation…”
Get more information

Association at SYNE1 in both bipolar disorder and recurrent major depression by Green, E K, Grozeva, D, Forty, L, Gordon-Smith, K, Russell, E, Farmer, A, Hamshere, M, Jones, I R, Jones, L, McGuffin, P, Moran, J L, Purcell, S, Sklar, P, Owen, M J, O'Donovan, M C, Craddock, N

“…Genome-wide association studies (GWAS) have identified a number of loci that have strong support for their association with bipolar disorder (BD). The…”
Get full text

Measuring depression: comparison and integration of three scales in the GENDEP study by Uher, R, Farmer, A, Maier, W, Rietschel, M, Hauser, J, Marusic, A, Mors, O, Elkin, A, Williamson, R J, Schmael, C, Henigsberg, N, Perez, J, Mendlewicz, J, Janzing, J G E, Zobel, A, Skibinska, M, Kozel, D, Stamp, A S, Bajs, M, Placentino, A, Barreto, M, McGuffin, P, Aitchison, K J

“…A number of scales are used to estimate the severity of depression. However, differences between self-report and clinician rating, multi-dimensionality and…”
Get more information

Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder by Chen, D T, Jiang, X, Akula, N, Shugart, Y Y, Wendland, J R, Steele, C J M, Kassem, L, Park, J-H, Chatterjee, N, Jamain, S, Cheng, A, Leboyer, M, Muglia, P, Schulze, T G, Cichon, S, Nöthen, M M, Rietschel, M, McMahon, F J

“…Meta-analyses of bipolar disorder (BD) genome-wide association studies (GWAS) have identified several genome-wide significant signals in European-ancestry…”
Get full text

Gene-environment interaction analysis of serotonin system markers with adolescent depression by ELEY, T. C, SUGDEN, K, CORSICO, A, GREGORY, A. M, SHAM, P, MCGUFFIN, P, PLOMIN, R, CRAIG, I. W

“…We report analyses from a study of gene-environment interaction in adolescent depression. The sample was selected from 1990 adolescents aged 10-20 years: those…”
Get full text

The varying impact of type, timing and frequency of exposure to childhood adversity on its association with adult psychotic disorder by Fisher, H L, Jones, P B, Fearon, P, Craig, T K, Dazzan, P, Morgan, K, Hutchinson, G, Doody, G A, McGuffin, P, Leff, J, Murray, R M, Morgan, C

“…Childhood adversity has been associated with onset of psychosis in adulthood but these studies have used only general definitions of this environmental risk…”
Get more information

DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP by Powell, T R, Smith, R G, Hackinger, S, Schalkwyk, L C, Uher, R, McGuffin, P, Mill, J, Tansey, K E

“…Transcriptional differences in interleukin-11 ( IL11 ) after antidepressant treatment have been found to correspond to clinical response in major depressive…”
Get full text

The diagnostic interview for psychoses (DIP): development, reliability and applications by Castle, D J, Jablensky, A, McGrath, J J, Carr, V, Morgan, V, Waterreus, A, Valuri, G, Stain, H, McGuffin, P, Farmer, A

“…We describe the development, reliability and applications of the Diagnostic Interview for Psychoses (DIP), a comprehensive interview schedule for psychotic…”
Get more information

Trajectories of change in depression severity during treatment with antidepressants by Uher, R, Muthén, B, Souery, D, Mors, O, Jaracz, J, Placentino, A, Petrovic, A, Zobel, A, Henigsberg, N, Rietschel, M, Aitchison, K J, Farmer, A, McGuffin, P

“…Response and remission defined by cut-off values on the last observed depression severity score are commonly used as outcome criteria in clinical trials, but…”
Get more information

Interaction between childhood maltreatment on immunogenetic risk in depression: Discovery and replication in clinical case-control samples by Cohen-Woods, S., Fisher, H.L., Ahmetspahic, D., Douroudis, K., Stacey, D., Hosang, G.M., Korszun, A., Owen, M., Craddock, N., Arolt, V., Dannlowski, U., Breen, G., Craig, I.W., Farmer, A., Baune, B.T., Lewis, C.M., Uher, R., McGuffin, P.

“…•Gene-environment study focusing on comprehensive analysis of immune candidate genes.•Interaction with childhood maltreatment in predicting recurrent…”
Get full text

Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project by Perroud, N, Uher, R, Ng, M Y M, Guipponi, M, Hauser, J, Henigsberg, N, Maier, W, Mors, O, Gennarelli, M, Rietschel, M, Souery, D, Dernovsek, M Z, Stamp, A S, Lathrop, M, Farmer, A, Breen, G, Aitchison, K J, Lewis, C M, Craig, I W, McGuffin, P

“…Suicidal thoughts during antidepressant treatment have been the focus of several candidate gene association studies. The aim of the present genome-wide…”
Get full text