Search Results - "McGrouther, Angus D"

Scarring Occurs at a Critical Depth of Skin Injury: Precise Measurement in a Graduated Dermal Scratch in Human Volunteers by Dunkin, Christopher S. J., Pleat, Jonathon M., Gillespie, Patrick H., Tyler, Michael P. H., Roberts, Anthony H. N., McGrouther, D Angus

“…The association between scarring and the depth of dermal injury or burn is clinically recognized but not quantified. The authors tested the hypothesis that…”
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Expression of Purinergic Receptors in Non-melanoma Skin Cancers and Their Functional Roles in A431 Cells by Greig, Aina V.H., Burnstock, Geoffrey, Linge, Claire, Healy, Vourneen, Lim, Philip, Clayton, Elizabeth, Rustin, Malcolm H.A., Angus McGrouther, D.

“…We investigated the use of purinergic receptors as a new treatment modality for nonmelanoma skin cancers. Purinergic receptors, which bind adenosine…”
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Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes by GREIG, Aina V. H, LINGE, Claire, TERENGHI, Giorgio, MCGROUTHER, D. Angus, BURNSTOCK, Geoffrey

“…We investigated the expression of P2X5, P2X7, P2Y1 and P2Y2 receptor subtypes in normal human epidermis and in relation to markers of proliferation (PCNA and…”
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Genome-Wide High-Resolution Screening in Dupuytren's Disease Reveals Common Regions of DNA Copy Number Alterations by Shih, Barbara B., MSc, Tassabehji, May, PhD, Watson, James S., MD, McGrouther, Angus D., MD, Bayat, Ardeshir, MD, PhD

“…Purpose Dupuytren's disease (DD) is a familial disorder with a high genetic susceptibility in white people; however, its etiopathogenesis remains unknown…”
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Decrease in Adhesion Formation by a Single Application of 5-Fluorouracil after Flexor Tendon Injury by Akali, Augustine, Khan, Umraz, Khaw, Peng T, McGrouther, Angus D

“…Using an animal model, the effect of a single intraoperative application of 5-fluorouracil on digital flexor tendon adhesions was assessed. After a standard…”
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Use of a non-contact 3D digitiser to measure the volume of keloid scars: a useful tool for scar assessment by Taylor, Ben, McGrouther, D. Angus, Bayat, Ardeshir

“…Summary Keloid scars often fail to respond to treatment, so research into new therapeutic regimes is important. However, research is limited by a scarcity of…”
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Recommendations on clinical proof of efficacy for potential scar prevention and reduction therapies by Bush, James A., McGrouther, D. Angus, Young, V. Leroy, Herndon, David N., Longaker, Michael T., Mustoe, Thomas A., Ferguson, Mark W. J.

“…ABSTRACT Cutaneous scarring is an enormous medical problem with approximately 100 million patients acquiring scars each year. Scar prevention/reduction…”
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‘Aggressive Keloid’: A Severe Variant of Familial Keloid Scarring by Bayat, Ardeshir, Arscott, Guyan, Ollier, William E R, Ferguson, Mark W J, McGrouther, D Angus

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Transforming Growth Factor-β1 Stimulation Enhances Dupuytren's Fibroblast Contraction in Response to Uniaxial Mechanical Load Within a 3-Dimensional Collagen Gel by Bisson, Marcus A., MD, Beckett, Kate S., MD, McGrouther, D. Angus, MD, Grobbelaar, Adriaan O., MMed, Mudera, Vivek, PhD

“…Purpose A function of fibroblasts is the generation of cytomechanical force within their surrounding extracellular matrix. Abnormalities in force generation…”
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5-fluorouracil selectively inhibits collagen synthesis by Bulstrode, Neil W, Mudera, Vivek, McGrouther, D Angus, Grobbelaar, Adriaan O, Cambrey, Alison D

“…Fibroproliferative disorders, such as Dupuytren's contracture of the hand, are characterized by excessive production of collagen. 5-Fluorouracil has been used…”
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The Effects of a Single Dose of 5-Fluorouracil on Keloid Scars: A Clinical Trial of Timed Wound Irrigation after Extralesional Excision by Uppal, Rajan S, Khan, Umraz, Kakar, Sanjeev, Talas, Gyorgyi, Chapman, Peter, McGrouther, Angus D

“…The possibility of altering the pathophysiology of keloid scars was investigated in 11 patients, using a single application of 5-fluorouracil solution for 5…”
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Strategies for cell engineering in tissue repair by Brown, Robert A., Smith, Kirsty D., Angus McGrouther, D.

“…Cellular and tissue engineering are new areas of research, currently attracting considerable interest because of the remarkable potential they have for…”
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Skin tension or skin compression? Small circular wounds are likely to shrink, not gape by Bush, James A, Ferguson, Mark W.J, Mason, Tracey, McGrouther, D. Angus

“…Summary The final appearance of a scar may be influenced by tension or mechanical factors [Borges AF. Scar prognosis of wounds. Br J Plast Surg 1960; 13…”
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The contractile properties and responses to tensional loading of Dupuytren's disease--derived fibroblasts are altered: a cause of the contracture? by Bisson, Marcus A, Mudera, Vivek, McGrouther, D Angus, Grobbelaar, Adriaan O

“…Dupuytren's disease causes disability because of the development of finger flexion deformities, with distinct nodule and cord formation. This results in…”
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Purinergic receptor expression in the regenerating epidermis in a rat model of normal and delayed wound healing by Greig, Aina V. H., James, Stuart E., McGrouther, D Angus, Terenghi, Giorgio, Burnstock, Geoffrey

“…:  This study investigated changes in the protein expression of purinergic receptors in the regenerating rat epidermis during normal wound healing, in…”
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The early surface cell response to flexor tendon injury by Jones, Martin E., Mudera, Vivek, Brown, Robert A., Cambrey, Alison D., Grobbelaar, Adriaan O., McGrouther, D.Angus

“…Purpose: The migratory response of surface fibroblasts to flexor tendon injury was studied by their selective labeling with a vital dye. Method: The surfaces…”
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The art and science of reconstructive surgery by McGROUTHER, D. ANGUS

“…Surgery is an ancient profession which has incorporated into its practice elements of art, science and commerce. Lecture goes beyond focusing on the…”
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A culture force monitor for measurement of contraction forces generated in human dermal fibroblast cultures: evidence for cell-matrix mechanical signalling by Eastwood, M, McGrouther, D A, Brown, R A

“…Non-contractile cells are able to exert 'tensional' forces on collagen substrate. Although such forces have been implicated in contraction during tissue repair…”
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Scarring occurs at a critical depth of skin injury : Precise measurement in a graduated dermal scratch in human volunteers. Discussion by DUNKIN, Christopher S. J, PLEAT, Jonathon M, GILLESPIE, Patrick H, TYLER, Michael P. H, ROBERTS, Anthony H. N, MCGROUTHER, D. Angus, MUSTOE, Thomas A, O'SHAUGHNESSY, Kristina

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5-Fluorouracil selectively inhibits collagen synthesis. Discussion by BULSTRODE, Neil W, MUDERA, Vivek, MCGROUTHER, D. Angus, GROBBELAAR, Adriaan O, CAMBREY, Alison D, CHANG, James, LONGAKER, Michael T

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